Effect of medication on habitual gait in people with PD: a feasibility study
Lead: Dr Silvia Del Din, Research Associate, Institute of Neuroscience, Faculty of Medical Sciences
Worsening of a person’s ability to walk (gait impairments) is a typical symptom for those with Parkinson’s disease. Issues with gait are also associated with an increased risk of falling, loss of independence and a poor quality of life. Gait impairments can be lessened through medication, but the overall benefits of medication have not been tested in real-life conditions (e.g. at home).
Find out more about Dr Del Din's project.
Do surviving dopaminergic neurons in Parkinson’s disease develop a senescent phenotype?
Lead: Dr Diana Jurk, Faculty Fellow, Institute Cell and Molecular Biosciences, Faculty of Medical Sciences
Ageing is the greatest risk factor for the development of neurodegenerative diseases including Parkinson's disease (PD). Many of the movement (motor) symptoms in PD, which can be accompanied by dementia, are thought to be caused by the death of brain cells in a region called the Substantia nigra and is associated with accumulation of alpha-synuclein aggregates. Ageing is believed to be a major risk factor for the development of this condition.
Find out more about Dr Jurk's project.
Pre-clinical validation of novel senolytic treatment
Lead: Dr Olena Kucheryavenko, Research Associate, Institute of Cell and Molecular Biosciences
Deterioration of tissues with age was shown to be reversible when old cells, known as senescent cells, were targeted and killed. However, it is not feasible to apply genetic interventions when it comes to patients, thus development of more feasible therapies is required. Our project will contribute to understanding of susceptibility of senescent cells to death in response to nutrients deprivation and modulation of nutrient-sensing pathways.
Find out more about Dr Kucheryavenko's project.
Restoring autophagy in muscle progenitors to prevent sarcopenia of ageing
Lead: Dr Nuria Martinez-Lopez, Senior Research Associate, Institute of Cell and Molecular Biosciences
As we age, we experience lower muscle mass. Muscle weakness can prevent older people from going about their daily lives and enjoying activities. Looking at ‘how we age’, this project examines how to restore the process of cell renewal to prevent the reduction in muscle strength.
Find out more about Dr Martinez-Lopez's project.
Ways to Wellness: can social prescribing maintain improved health among older chronically ill people?
Lead: Dr Suzanne Moffatt, Senior Lecturer, Institute of Health and Society
Ways to Wellness is a social prescribing initiative aimed at people aged 40-74 years with chronic health conditions. Through support from a link worker, and community services, patients are helped to improve health-related behaviours, social involvement and wellbeing. This study will follow up to 30 people with chronic health problems.
Find out more about Dr Moffatt's project.
Management and data administration systems to facilitate delivery and evaluation of community based interventions with multiple
Lead: Dr Linda Penn, Research Associate, Institute of Health and Society
The NHS ‘Five Year Forward View’ emphasises the importance of disease prevention. Lifestyle intervention can support people to make healthy behaviour choices and prevent disease. We will examine how management information systems can support the delivery and evaluation of lifestyle interventions.
Find out more about Dr Penn's project.
Mechanisms of beneficial effects of inorganic nitrate and chicoric acid on cultured adipocytes under high fat conditions
Lead: Dr Gabriele Saretzki, Lecturer, Institute of Cell and Molecular Biosciences
This project is primarily intended to assist planners to design the built environment in such a way that fully addresses the barriers that can face people with age related mobility impairments. To achieve this, the project is aimed to provide an efficient means for automatically mapping these barriers, especially those which are more subtle (and therefore less intuitive to planners), but particularly problematic for this group.
Find out more about Dr Saretzki's project.
From Ageing Research to Ageing Policy: A Collaborative Approach
Lead: Professor Tom Scharf, Professor of Social Gerontology, Institute of Health and Society
Building on Newcastle University’s global reputation for its activities in the multidisciplinary field of ageing research, this project seeks to initiate a step change in the process of translating research findings into policy impacts. By catalysing the University’s collaboration with the International Longevity Centre UK (ILC-UK), the UK’s leading think tank on ageing, the project aims to connect the findings of research undertaken at Newcastle to influential policy audiences. The project supports mutually beneficial interactions between the team at ILC-UK and researchers at all career stages and from all faculties at Newcastle.
Find out more about Professor Scharf's project.
Chronic illness (CHD), gender and the ageing body: an exploratory investigation of the experiences and motivations for sustained
Lead: Dr Anu Vaittinen, Research Associate, Institute of Health and Society
Chronic illness (CVD), gender and the ageing body. This project is an investigation into the experiences, motivations and sustained involvement in community cardiac rehabilitation in the North East of England.
Find out more about Dr Vaittinen's project.
Using wrist-worn inertial sensing on a manual wheelchair to measure the accessibility of the built environment
Lead: Dr Sebastian Weise, Lecturer in Digital Civics, Architecture, Planning and Landscape
This project is primarily intended to assist planners to design the built environment in such a way that fully addresses the barriers that can facepeople with age related mobility impairments using wrist-worn sensors on manual wheelchair users to convertmovement patterns into a measure of ‘difficulty’.
Find out more about Dr Weise's project.