Aspirin cuts hereditary cancer risks by more than half

photograph

Research at Newcastle has finally provided proof that taking a regular dose of aspirin reduces the long-term risk of cancer in people with a family history of the disease by around 60 per cent.

The international collaboration, lead by researchers at the Universities of Newcastle and Leeds, whose work is published today in The Lancet, reveals that the benefits only become obvious several years after taking the aspirin.

Evidence of the benefits of aspirin has been accumulating for over 20 years but these are the first results from a randomised controlled trial assessing the effect of aspirin on cancer.

Late last year an analysis of people who had taken part in the early aspirin trials to prevent heart attacks and strokes showed that in subsequent years they developed fewer cancers. The missing piece of the jigsaw was a randomised trial specifically looking at its effect on cancer. 

Professor Sir John Burn, of the University's Institute of Genetic Medicine, who led the international research collaboration said: 'What we have finally shown is that aspirin has a major preventative effect on cancer but this doesn’t become apparent until years later.'

The study involving scientists and clinicians from 43 centres in 16 countries followed nearly 1,000 patients, in some cases for over 10 years.

The trial was overseen by Newcastle Hospitals NHS Foundation Trust and funded by the UK Medical Research Council, Cancer Research UK, the European Union and Bayer Pharma.

The study focused on people with Lynch syndrome, an inherited genetic disorder which affects genes responsible for detecting and repairing damage in the DNA. Around half of these people develop cancer, mainly in the bowel and womb.

Between 1999 and 2005 a total 861 people began either taking two aspirins (600 mg) every day for two years or a placebo. At the end of the treatment stage in 2007 there was no difference between those who had taken aspirin and those who had not. However, the study team anticipated a longer term effect and designed the study for continued follow-up.

By 2010 there had been 19 new colorectal cancers among those who had received aspirin and 34 among those on placebo. The incidence of cancer among the group who had taken aspirin had halved—and the effect began to be seen five years after patients starting taking the aspirin. 

A further analysis focused on the patients who took aspirin for at least two years according to the original design—some 60 per cent of the total—and here the effects of aspirin were even more pronounced: a 63 per cent reduced incidence of colorectal cancer was observed with 23 bowel cancers in the placebo group but only 10 in the aspirin group.

Looking at all cancers related to Lynch syndrome, including cancer of the endometrium or womb, almost 30 per cent of the patients taking the placebo had developed a cancer compared to around 15 per cent of those taking the aspirin.

'What surprised us was that there was no difference in the number of people developing polyps which are thought to be the precursors of cancer. But, many fewer patients who had been taking aspirin years before went on to develop cancers,' said Professor Tim Bishop from the University of Leeds, whose team was responsible for the statistical analysis.

Sir John explained: 'We have succeeded in showing the benefits of aspirin because we had a lot of long term data and because Lynch syndrome is associated with rapid development of cancer.

'It has also demonstrated how our research community and families with inherited forms of cancer can work together to answer questions important for the whole population.'

People should consult their doctor before beginning to take aspirin on a regular basis, advises Sir John, as aspirin is known to bring with it a risk of stomach complaints, including ulcers. 

'However, if there is a strong family history of cancer then people may want to weigh up the cost-benefits particularly as these days drugs which block acid production in the stomach are available over the counter,' he added.

Professor Nick Hastie, Director of the Medical Research Council Human Genetics Unit, said: 'Bowel cancer is the second commonest cause of cancer death in the UK, being responsible for 16,000 deaths a year. This landmark study provides the clearest evidence yet that aspirin can help protect against development of this disease. As we learn more about the underlying mechanism of this anti-tumour effect, we will eventually be able to develop new ways of preventing and treating cancer.'

The international team is now preparing a large-scale follow-up trial and wants to recruit 3,000 people across the world to test the effects of different doses of aspirin. The trial will compare two aspirin a day with a range of lower doses to see if the protection offered is the same. 

More information on the next trial, and how to take part, can be found at: www.capp3.org

Image credit with thanks: Jenny R (under Creative Commons licence)

published on: 28th October 2011

Return to AlumNews