Design and development of highly specific 'bioelectronic' interfaces between inorganic surfaces and biological species (antibodies, microbial cells, enzymes and redox proteins). This work has led to the production of a number of electrochemical and microelectromechanical sensor systems capable of the direct, rapid measurement of biological and chemical species in complex matrices. The current work being carried out by the Diagnostic and Therapeutic Technologies Research Group can be broadly defined in three inter-related, multi-disciplinary areas. These are:
1. Development of microbial and biological sensors based on microelectromechanical systems (bio-MEMS) - Collaboration with Dr Neil Keegan.
2. Development of near-patient technology platforms for rapid, quantitative immunometric measurement of biochemical markers of disease.
3. Development of multi-analyte sensor array platforms for direct, simultaneous intra- and extra-cellular monitoring of reactive oxygen species and the application of these to understanding related biochemical mechanisms involved in disease processes - Collaboration with Dr Phil Manning.