Newcastle University

Qualifications

BSc (Hons) Liverpool 1992
PhD Liverpool 1996

Previous Positions

1996-1998 Grace Gill's lab at Harvard Medical School where I worked on CREG (cellular repressor of EIA-like genes).
1998-2003 Brian Morgan's lab at University of Newcastle investigating the regulation of the eukaryotic oxidative stress response

Memberships

Biochemical Society, Genetics Society and Genetics Society of America

Honours and Awards

MRC Career Development Award (2003-2008)

Research Interests

Exposure to sunlight, immune cell attack and aerobic metabolism generate highly toxic chemicals known as 'reactive oxygen species (ROS)'. These ROS, such as peroxide, cause cell damage (oxidative stress) that has been implicated in the initiation and development of many diseases, including cancer, heart disease and diabetes. Increased oxidative damage is also associated with ageing. We are interested in understanding the molecular mechanisms by which eukaryotic cells sense and respond to ROS, for example, to signal an increase in the production of protective proteins. We use the fission yeast Schizosaccharomyces pombe and the nematode worm Caenorhabditis elegans as genetically amenable model eukaryotes in which to study these ROS-sensing and signalling mechanisms. In multicellular organisms, in addition to causing oxidative stress, ROS are also generated and employed as signalling molecules to regulate various biological processes. The simplicity, ease of genetic manipulation and analysis, as well as the wide-range of post-genomic resources available, render C. elegans an ideal multicellular organism in which to identify cell-type specific roles for ROS-signalling mechanisms in development and ageing.

Lab Members

Alison Day PhD, Jonathon Brown PhD, Joanne Stamford, Emma Button, Lewis Tomalin, Johnathan Winter, Heather Latimer, Monika Olahova PhD (visiting researcher)

Former lab members

2005-2008 Sarah Taylor PhD (now NHS cytogeneticist), 2007-2010 Jonathan Rand PhD (now Industrial R &D position), 2005-2011 Monika Olahova PhD (now postdoc fellow in USA), 2007-2012 Helen Crook PhD (now training as high school science teacher)

Funding

Research in my lab is currently funded by the MRC, BBSRC, Research Councils UK and Cancer Research UK. *PhD studentships available*

• Day AM, Brown JD, Taylor SR, Rand JD, Morgan BA, Veal EA. Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival. Molecular Cell 2012, 45(3), 398-408.
• Veal EA, Olahova M. Translating a Low-Sugar Diet into a Longer Life by Maintaining Thioredoxin Peroxidase Activity of a Peroxiredoxin. Molecular Cell 2011, 43(5), 699-701.
• Veal EA, Day AM. Hydrogen peroxide as a signaling molecule. Antioxidants and Redox Signaling 2011, 15(1), 147-151.
• Day AM, Veal EA. Hydrogen Peroxide-sensitive Cysteines in the Sty1 MAPK Regulate the Transcriptional Response to Oxidative Stress. Journal of Biological Chemistry 2010, 285(10), 7505-7516.
• Oláhová M, Taylor SR, Khazaiphoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA. A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proceedings of the National Academy of Sciences of the United States of America 2008, 105(50), 19839-19844.
• Veal EA, Day AM, Morgan BA. Hydrogen Peroxide Sensing and Signaling. Molecular Cell 2007, 26(1), 1-14.
• Morgan BA, Veal EA. Typical 2-Cys peroxiredoxins in Yeast. In: Flohe, L; Harris, R, ed. Peroxiredoxin Systems: Structures and Functions. New York: Springer, 2007, pp.253-265.
• Bozonet SM, Findlay VJ, Day AM, Cameron J, Veal EA, Morgan BA. Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide. Journal of Biological Chemistry 2005, 280(24), 23319-23327.
• Veal EA, Findlay VJ, Day AM, Bozonet SM, Evans JM, Quinn J, Morgan BA. A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Molecular Cell 2004, 15(1), 129-139.
• Veal EA, Ross SJ, Malakasi P, Peacock E, Morgan BA. Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor. Journal of Biological Chemistry 2003, 278(33), 30896-30904.
• Veal EA, Mark Toone W, Jones N, Morgan BA. Distinct roles for glutathione S-transferases in the oxidative stress response in Schizosaccharomyces pombe. Journal of Biological Chemistry 2002, 277(38), 35523-35531.
• Pic A, Lim F-L, Ross SJ, Veal EA, Johnson AL, Sultan MRA, West AG, Johnston LH, Sharrocks AD, Morgan BA. The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. EMBO Journal 2000, 19(14), 3750-3761.
• Veal E, Groisman R, Eisenstein M, Gill G. The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells. Oncogene 2000, 19(17), 2120-2128.
• Veal E, Eisenstein M, Tseng ZH, Gill G. A Cellular Repressor of E1A-stimulated Genes That Inhibits Activation by E2F. Molecular and Cellular Biology 1998, 18(9), 5032-5041.
• Veal EA, Jackson MJ. The role of the proto-oncogene c-myc in mouse skeletal muscle. International Journal of Biochemistry and Cell Biology 1998, 30(7), 811-821.