BSc (Hons) Liverpool 1992
PhD Liverpool 1996
1996-1998 Grace Gill's lab at Harvard Medical School where I worked on regulation of mammalian transcription and CREG (cellular repressor of EIA-like genes).
1998-2003 Brian Morgan's lab at University of Newcastle investigating the regulation of eukaryotic oxidative stress responses
2004-2008 MRC Career Development Fellow, Newcastle University
2006-2011 RCUK Academic Fellow, Newcastle University
Biochemical Society, Genetics Society, Genetics Society of America, British Society for Research on Ageing
MRC Career Development Award (2003-2008)
Exposure to sunlight, immune cell attack and aerobic metabolism generate highly toxic chemicals known as 'reactive oxygen species (ROS)'. These ROS, such as peroxide, cause cell damage (oxidative stress) that has been implicated in the initiation and development of many diseases, including cancer, heart disease and diabetes. Increased oxidative damage is also associated with ageing. We are interested in understanding the molecular mechanisms by which eukaryotic cells sense and respond to ROS, for example, to signal an increase in the production of protective proteins. We use the fission yeast Schizosaccharomyces pombe and the nematode worm Caenorhabditis elegans as genetically amenable model eukaryotes in which to study these ROS-sensing and signalling mechanisms. In multicellular organisms, in addition to causing oxidative stress, ROS are also generated and employed as signalling molecules to regulate various biological processes. The simplicity, ease of genetic manipulation and analysis, as well as the wide-range of post-genomic resources available, render C. elegans an ideal multicellular organism in which to identify cell-type specific roles for ROS-signalling mechanisms in development and ageing.
Alison Day PhD, Jonathon Brown PhD, Joanne Stamford, Emma Button, Lewis Tomalin, Johnathan Winter, Heather Latimer,
Former lab members and what-they-did-next:
2005-2008 Sarah Taylor PhD (NHS cytogeneticist), 2007-2010 Jonathan Rand PhD (Industrial R &D position), 2005-2011 Monika Olahova PhD (postdoc fellow), 2007-2012 Helen Crook PhD (high school science teacher)
Our research has been funded by the MRC, BBSRC, Research Councils UK and Cancer Research UK.
*BBSRC-funded PhD studentship available*