Dr Elizabeth Veal
Reader in Molecular Biology
- Email: email@example.com
- Telephone: +44 (0) 191 208 7596/7444 (lab)
- Fax: +44 (0) 191 208 7424
- Address: Institute for Cell and Molecular Biosciences
Newcastle upon Tyne
BSc (Hons) Liverpool 1992
PhD Liverpool 1996
1996-1998 Grace Gill's lab at Harvard Medical School where I worked on regulation of mammalian transcription and CREG (cellular repressor of EIA-like genes).
1998-2003 Brian Morgan's lab at University of Newcastle investigating the regulation of eukaryotic oxidative stress responses
2004-2008 MRC Career Development Fellow, Newcastle University
2006-2011 RCUK Academic Fellow, Newcastle University
Biochemical Society, Genetics Society, Genetics Society of America, British Society for Research on Ageing
Honours and Awards
MRC Career Development Award (2003-2008)
Exposure to sunlight, immune cell attack and aerobic metabolism generate highly toxic chemicals known as 'reactive oxygen species (ROS)'. These ROS, such as peroxide, cause cell damage (oxidative stress) that has been implicated in the initiation and development of many diseases, including cancer, heart disease and diabetes. Increased oxidative damage is also associated with ageing. We are interested in understanding the molecular mechanisms by which eukaryotic cells sense and respond to ROS, for example, to signal an increase in the production of protective proteins. We use the fission yeast Schizosaccharomyces pombe and the nematode worm Caenorhabditis elegans as genetically amenable model eukaryotes in which to study these ROS-sensing and signalling mechanisms. In multicellular organisms, in addition to causing oxidative stress, ROS are also generated and employed as signalling molecules to regulate various biological processes. The simplicity, ease of genetic manipulation and analysis, as well as the wide-range of post-genomic resources available, render C. elegans an ideal multicellular organism in which to identify cell-type specific roles for ROS-signalling mechanisms in development and ageing. We also use both experimental and computational approaches to examine how ROS-sensing mechanisms identified in yeast and worms are conserved in human cells.
Joanne Stamford, Johnathan Winter, Heather Latimer, Zoe Underwood, Michelle Wray, Marti Cadena-Sandoval, Yunhui Zhu
Former lab members and what-they-did-next:
Alison Day PhD 2004-2013 (postdoc position), 2005-2008 Sarah Taylor PhD (NHS cytogeneticist after PhD in Veal lab), 2005-2011 Monika Olahova PhD(PhD in Veal lab awarded faculty medal, postdoc in Veal lab, then postdoc fellow in USA), 2007-2012 Helen Crook PhD (high school science teacher after MRes/PhD and short postdoc in Veal lab), 2009-2013 Emma Button PhD (Industrial R&D position after MRes/PhD in Veal lab), 2007-2010Jonathan Rand PhD (Industrial R &D position after postdoc in Veal lab), 2009-2013 Jonathon Brown PhD (postdoc position after postdoc in Veal lab), 2011-2015 Lewis Tomalin (postdoc at Rockefeller University, USA after PhD in Veal lab).
We have received funding from the MRC, BBSRC, Research Councils UK and Cancer Research UK.
- Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ-L, Shanley DP, Veal EA. Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed. Free Radicals in Biology and Medicine 2016, 95, 333-348.
- Latimer HR, Veal EA. Peroxiredoxins in Regulation of MAPK Signalling Pathways; Sensors and Barriers to Signal Transduction. Molecules and Cells 2016, 39(1), 40-45.
- Oláhová M, Veal EA. A peroxiredoxin, PRDX-2, is required for insulin secretion and Insulin/IIS-dependent regulation of stress resistance and longevity. Aging Cell 2015, 14(4), 558-568.
- Crook-McMahon HM, Olahova M, Button EL, Winter JJ, Veal EA. Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals. BMC Biology 2014, 12, 64.
- Veal EA, Tomalin LE, Morgan BA, Day AM. The fission yeast Schizosaccharomyces pombe as a model to understand how peroxiredoxins influence cell responses to hydrogen peroxide. Biochemistry Society Transactions 2014, 42(4), 909-916.
- Jiménez-Hidalgo M, Kurz CL, Pedrajas JR, Naranjo-Galindo FJ, González-Barrios M, Cabello J, Sáez AG, Lozano E, Button EL, Veal EA, Fierro-González JC, Swoboda P, Miranda-Vizuete A. Functional characterization of thioredoxin 3 (TRX-3), a Caenorhabditis elegans intestine-specific thioredoxin. Free Radical Biology and Medicine 2014, 68, 205-219.
- Brown JD, Day AM, Taylor SR, Tomalin LE, Morgan BA, Veal EA. A Peroxiredoxin Promotes H2O2 Signaling and Oxidative Stress Resistance by Oxidizing a Thioredoxin Family Protein. Cell Reports 2013, 5(5), 1425-1435.
- Patterson M, McKenzie C, Smith D, da Silva Dantas A, Sherston S, Veal EA, Morgan B, MacCallum D, Erwig LP, Quinn J. Ybp1 and Gpx3 Signaling in Candida albicans Govern Hydrogen Peroxide-Induced Oxidation of the Cap1 Transcription Factor and Macrophage Escape. Antioxidants & Redox Signaling 2013, n/a, n/a.
- Day AM, Brown JD, Taylor SR, Rand JD, Morgan BA, Veal EA. Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival. Molecular Cell 2012, 45(3), 398-408.
- Veal EA, Day AM. Hydrogen peroxide as a signaling molecule. Antioxidants and Redox Signaling 2011, 15(1), 147-151.
- Veal EA, Olahova M. Translating a Low-Sugar Diet into a Longer Life by Maintaining Thioredoxin Peroxidase Activity of a Peroxiredoxin. Molecular Cell 2011, 43(5), 699-701.
- Day AM, Veal EA. Hydrogen Peroxide-sensitive Cysteines in the Sty1 MAPK Regulate the Transcriptional Response to Oxidative Stress. Journal of Biological Chemistry 2010, 285(10), 7505-7516.
- Oláhová M, Taylor SR, Khazaiphoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA. A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proceedings of the National Academy of Sciences 2008, 105(50), 19839-19844.
- Veal EA, Day AM, Morgan BA. Hydrogen Peroxide Sensing and Signaling. Molecular Cell 2007, 26(1), 1-14.
- Morgan BA, Veal EA. Typical 2-Cys peroxiredoxins in Yeast. In: Flohe, L; Harris, R, ed. Peroxiredoxin Systems: Structures and Functions. New York: Springer, 2007, pp.253-265.
- Bozonet SM, Findlay VJ, Day AM, Cameron J, Veal EA, Morgan BA. Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide. Journal of Biological Chemistry 2005, 280(24), 23319-23327.
- Veal EA, Findlay VJ, Day AM, Bozonet SM, Evans JM, Quinn J, Morgan BA. A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Molecular Cell 2004, 15(1), 129-139.
- Veal EA, Ross SJ, Malakasi P, Peacock E, Morgan BA. Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor. Journal of Biological Chemistry 2003, 278(33), 30896-30904.
- Veal EA, Mark Toone W, Jones N, Morgan BA. Distinct roles for glutathione S-transferases in the oxidative stress response in Schizosaccharomyces pombe. Journal of Biological Chemistry 2002, 277(38), 35523-35531.
- Pic A, Lim F-L, Ross SJ, Veal EA, Johnson AL, Sultan MRA, West AG, Johnston LH, Sharrocks AD, Morgan BA. The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. EMBO Journal 2000, 19(14), 3750-3761.
- Veal E, Groisman R, Eisenstein M, Gill G. The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells. Oncogene 2000, 19(17), 2120-2128.
- Veal E, Eisenstein M, Tseng ZH, Gill G. A Cellular Repressor of E1A-stimulated Genes That Inhibits Activation by E2F. Molecular and Cellular Biology 1998, 18(9), 5032-5041.
- Veal EA, Jackson MJ. The role of the proto-oncogene c-myc in mouse skeletal muscle. International Journal of Biochemistry and Cell Biology 1998, 30(7), 811-821.
- Morgan BA, Veal EA. Functions of typical 2-Cys peroxiredoxins in yeast. SubCellular Biochemistry 2007, 44, 253-65.
- Ikeh MA, Kastora SL, Day AM, Herrero-de-Dios CM, Tarrant E, Waldron KJ, Banks AP, Bain JM, Lydall D, Veal EA, MacCallum DM, Erwig LP, Brown AJ, Quinn J. Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis. Molecular Biology of the Cell 2016, 27(17), 2784-2801.