Newcastle University

Roles and Responsibilities

Dean of Undergraduate Studies, Faculty of Medical Sciences

Qualifications

B.Sc.; M.Sc.; Ph.D.; M.B.A.

Memberships

British Society for Immunology

Research Interests

Antibody and T lymphocyte responses in bird breeder`s lung

Regulation of immunoglobulin isotype production in man

Immunoregulation of polysaccharide antibody responses

Prof Calvert`s research interests focus on various aspects of human immune responses. Current projects include 1) Pigeon intestinal mucin as an antigen in bird breeders` lung. The IgG subclass responses to this antigen have been shown to differ significantly between symptomatic and asymptomatic but antibody positive pigeon fanciers. We have recently identified a novel oligosaccharide epitope on pigeon mucin. Currently research is focused on the investigation of T cell responses to this antigen. 2) Antibody responses to polysaccharide antigens. The mechanisms underlying these responses are being investigated. I collaborate closely in this work with Dr Chris Baldwin.

Postgraduate Supervision

Yes

• Bevitt D, Baldwin C, Calvert J. Intervening early: attendance and performance monitoring as a trigger for first year support in the biosciences. Bioscience Education 2010, 15(4).
• Hughes M, Brown K, Calvert JE. Reinforcing the links between teaching and research: evaluation of a scheme to employ undergraduate students as laboratory assistants. Bioscience Education 2008, 12.
• Calvert JE, Bradley PM. Development of an anatomy resource for biomedical students: an e-learning practice case study. The Higher Education Academy, Centre for Bioscience, 2007. Available at: http://www.bioscience.heacademy.ac.uk/events/themes/elearn/elearncs.aspx.
• Calvert J, Jowett T, Cotterill S. E-portfolios in Bioscience. Centre for Bioscience Bulletin 2007, 20, 3.
• Cann AJ, Calvert JE, Masse K, Moffat KG. Assessed Online Discussion Groups In Biology Education. Bioscience Education E-journal 2006, 8, 8-4.
• Bradley PM, Calvert JE. Catch Up Biology for the Medical Sciences. Bloxham, Oxfordshire: Scion, 2006.
• Brown C, Wiles C, Calvert JE. Skills and knowledge needs among recent Bioscience graduates — how do our courses measure up?. Bioscience Education Journal 2005, 6(2), 18.
• Baldwin CI, Allen A, Bourke S, Hounsell E, Calvert JE. Mucin oligosaccharides and pigeon fanciers' lung. In: Glycobiology and Medicine: 7th Jenner Glycobiology and Medicine Symposium. 2005, London, UK: Springer New York LLC.
• Baldwin CI, Allen A, Bourke S, Hounsell E, Calvert JE. Mucin oligosaccharides and pigeon fanciers' lung. In: 7th Jenner Glycobiology and Medicine Symposium. 2004, London: Advances in Experimental Medicine and Biology: Springer.
• Lilic D, Gravenor I, Robson N, Lammas DA, Drysdale P, Calvert JE, Cant AJ, Abinun M. Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis. Infection and Immunity 2003, 71(10), 5690-5699.
• Bourke SJ, Calvert JE, Baldwin CI, Worthy S. Occupational extrinsic allergic alveolitis. Imaging 2003, 15(1), 23-30.
• Bourke SJ, Dalphin JC, Boyd G, McSharry C, Baldwin CI, Calvert JE. Hypersensitivity Pneumonitis: Current Concepts. European Respiratory Journal 2001, 18(32), 81s-92s.
• Hounsell EF, Renouf DV, Baldwin C, Calvert J, Allen A, Haavik S. Analysis of mucin glycopeptide structure, function and antigenicity. In: Bara J, Christen, Y and Droy-Lefaix MT, ed. Digestive Mucus: from Research to Clinical Implications. Paris: Irvinn Editions, 2000, pp.87-92.
• Baldwin CI, Calvert JE, Renouf DV, Kwok C, Hounsell EF. Analysis of pigeon intestinal mucin allergens using a novel dot blot assay. Carbohydrate Research 2000, 326(1), 43-49.
• Baldwin CI, Calvert JE, Todd A, Bourke S, Allen A. IgG-subklassenantikorper gegun Muzin des Tauben-darms bei Taubenzuchterlunge (IgG subklassenantikorper gegun of mucin in pigeon intestine Taubenzuchterlunge). Allergologie 2000, 23, 50.
• Baldwin CI, Calvert JE, Allen A, Hounsell EF. Pigeon fanciers' lung: characterisation of antigenic glycoforms of pigeon intestinal mucin. In: Joint Congress of the British Society for Immunology and the British Society for Allergy and Clinical Immunology. 1999, Harrogate, UK: Wiley-Blackwell Publishing Ltd.
• Khan ZJ, Diboll J, Baldwin CI, Calvert JE. Pigeon fanciers' lung: complement activation by antigens and immune complexes. In: Joint Congress of the British Society for Immunology and the British Society for Allergy and Clinical Immunology. 1999, Harrogate, UK: Wiley-Blackwell Publishing Ltd.
• Baldwin C., Todd A., Bourke S., Allen A. and Calvert J. IgG subclass responses to pigeon intestinal mucin are related to development of pigeon fanciers' lung. Clinical and Experimental Allergy 1998, 28, 349-357.
• Baldwin CI, Stevens B, Connors S, Todd A, Bourke SJ, Calvert JE, Allen A. Pigeon fanciers' lung: The mucin antigen is present in pigeon droppings and pigeon bloom. International Archives of Allergy and Immunology 1998, 117(3), 187-193.
• Baldwin C., Todd A., Bourke S., Allen A. and Calvert J. Pigeon fanciers' lung: effects of smoking on serum and salivary antibody responses to pigeon antigens. Clinical and Experimental Immunology 1998, 113, 166-172.
• A. Crossley, J. E. Calvert, P. R. A. Taylor and A. M. Dickinson. A comparison of monoclonal antibody immobilization of platelet antigen (MAIPA) and immunobead methods for detection of GPIIb/IIIa antiplatelet antibodies in immune thrombocytopenic purpura. Transfusion Medicine 1997, 7, 127-134.
• Baldwin, CI, Calvert, JE, Todd, A, Bourke, S, Allen, A. Smoking and immune responses in pigeon fanciers' lung. Biochem Soc Trans 25 (2) 325S 1997.
• Proctor SJ, Crossley AP, Calvert JE, Dickinson AM. Autoimmune (idiopathic) thrombocytopenic purpura. Lancet 1997, 350(9074), 368.
• Crossley, A. R., Dickinson, A. M., Proctor, S. J., Calvert, J. E. Effects of interferon-α therapy on immune parameters in immune thrombocytopenic purpura. Autoimmunity 1996, 24(2), 81-100.
• Foster HE, Calvert JE, Kelly CA, Griffiths ID. The levels of CD5+ B cells are not increased in probands with Primary Sjogren's syndrome or their relatives. Autoimmunity 1993, 5, 93-97.
• Bird AG and Calvert JE. B Lymphocytes in Human Disease. Oxford, England: Oxford University Press, 1988.
• P. Bird,J. E. Calvert,H. Mitchison,N. R. Ling,M. Bassendine,O. F. James. Lymphocytes from patients with primary biliary cirrhosis spontaneously secrete high levels of IgG3 in culture. Clin Exp Immunol 1988, 71(3), 475-80.
• Gennery AR, Cant AJ, Baldwin CI, Calvert JE. Characterization of the impaired antipneumococcal polysaccharide antibody production in immunosuppressed pediatric patients following cardiac transplantation. Journal of Clinical Immunology 2001, 21(1), 43-50.
• Shenton FC, Calvert JE, Allen A, Baldwin CI. Pigeon fanciers’ lung: T cell responses to pigeon intestinal mucin. Immunology 2001, 104, sl, 109.
• Calvert JE, Bourke S, Baldwin CI. Pigeon Fancier's Lung. The Racing Pigeon 1999.
• Calvert JE, Baldwin CI, Allen A, Todd A, Bourke SJ. Pigeon fanciers' lung: a complex disease?. Clinical and Experimental Allergy 1999, 29(2), 166-175.
• Baldwin CI, Allen A, Calvert JE, Bourke SJ, Hounsell EF. Pigeon fanciers' lung: Identification of antigenic oligosaccharides of pigeon intestinal mucin. In: American Journal of Respiratory and Critical Care Medicine. 1999, American Thoracic Society.
• Baldwin CI, Todd A, Bourke SJ, Allen A, Calvert JE. Pigeon fanciers' lung: identification of disease-associated carbohydrate epitopes on pigeon intestinal mucin. Clinical and Experimental Immunology 1999, 117(2), 230-236.