Dr Julie IrvingReader in Experimental Haematology
Email: julie.irving@ncl.ac.uk Telephone: +44 (0) 191 246 4369 Fax: +44 (0) 191 246 4301 Address: Northern Institute for Cancer Research
Rehe K, Wilson K, Bomken S, Williamson D, Irving J, den Boer ML, Stanulla M, Schrappe M, Hall AG, Heidenreich O, Vormoor J. Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations .
EMBO Molecular Medicine 2013, 5 (1), 38-51.
Nicholson L, Knight T, Matheson E, Minto L, Case M, Sanichar M, Bomken S, Vormoor J, Hall A, Irving J. Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia .
Genes, Chromosomes & Cancer 2012, 51 (3), 250-256.
Enciso-Mora V, Hosking FJ, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Tomlinson IPM, Allan JM, Taylor M, Greaves M, Houlston RS. Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia .
Leukemia 2012, 26 (10), 2212-2215.
Fiser K, Sieger T, Schumich A, Wood B, Irving J, Mejstrikova E, Dworzak MN. Detection and monitoring of normal and leukemic cell populations with hierarchical clustering of flow cytometry data .
Cytometry Part A 2012, 81A (1), 25-34.
Hunter JE, Willmore E, Irving JAE, Hostomsky Z, Veuger SJ, Durkacz BW. NF-kappa B mediates radio-sensitization by the PARP-1 inhibitor, AG-014699 .
Oncogene 2012, 31 (2), 251-264.
de Brito LR, Batey MA, Zhao Y, Squires MS, Maitland H, Leung HY, Hall AG, Jackson G, Newell DR, Irving JAE. Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma .
Leukemia Research 2011, 35 (9), 1233-1240.
Fordham SE, Matheson EC, Scott K, Irving JAE, Allan JM. DNA mismatch repair status affects cellular response to Ara-C and other anti-leukemic nucleoside analogs .
Leukemia 2011, 25 (6), 1046-1049.
Rand V, Parker H, Russell LJ, Schwab C, Ensor H, Irving J, Jones L, Masic D, Minto L, Morrison H, Ryan S, Robinson H, Sinclair P, Moorman A, Strefford J, Harrison CJ. Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia .
Blood 2011, 117 (25), 6848-6855.
Al-Balool HH, Weber D, Liu Y, Wade M, Guleria K, Nam PL, Clayton J, Rowe W, Coxhead J, Irving J, Elliott DJ, Hall AG, Santibanez-Koref M, Jackson MS. Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant .
Genome Research 2011, 21 (11), 1788-1799.
Squires M, Ward G, Saxty G, Berdini V, Cleasby A, King P, Angibaud P, Perera T, Fazal L, Ross D, Jones CG, Madin A, Benning RK, Vickerstaffe E, O'Brien A, Frederickson M, Reader M, Hamlett C, Batey MA, Rich S, Carr M, Miller D, Feltell R, Thiru A, Bethell S, Devine LA, Graham BL, Pike A, Cosme J, Lewis EJ, Freyne E, Lyons J, Irving J, Murray C, Newell DR, Thompson NT. Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models .
Molecular Cancer Therapeutics 2011, 10 (9), 1542-1552.
Nicholson L, Evans C, Matheson EC, Minto L, Keilty C, Schwab C, Harrison CJ, Hall AG, Redfern C, Whetton A, Irving J. Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target .
In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH) . 2011, San Diego, California, USA: American Society of Hematology.
Ryan SL, Rand V, Schwab C, Morrison H, Matheson E, Minto L, Rahman T, Keavney B, Bown N, Skinner R, Schnittger S, Santibanez-Koref M, Grossmann V, Kohlmann A, Irving J, Harrison CJ. Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients .
In: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH) . 2011, San Diego, California, USA: American Society of Hematology.
Peasland A, Matheson E, Hall A, Irving J. Alternative splicing of hMLH1 in childhood acute lymphoblastic leukaemia and characterisation of the variably expressed Δ9/10 isoform as a dominant negative species .
Leukemia Research 2010, 34 (3), 322-327.
Jiang XY, Grant H, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, Brien SO, Khorashad JS, Gerrard G, Wang LH, Irving J, Wang M, Karran L, Dyer MJS, Forrest DL, Page K, Eaves CJ, Woolfson A. Analysis of BCR ABL1 Tyrosine Kinase Domain Mutations In Primitive Chronic Myeloid Leukemia Cells Identifies a Unique Mutator Phenotype .
In: 52nd Annual Meeting of the American Society of Hematology . 2010, Orlando, FL: Blood: American Society of Hematology.
Grant H, Jiang X, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, O'Brien S, Khorashad JS, Gerrard G, Wang L, Irving JAE, Wang M, Karran L, Dyer MJS, Forrest D, Page K, Eaves CJ, Woolfson A. Analysis of BCR-ABL1 tyrosine kinase domain mutational spectra in primitive chronic myeloid leukemia cells suggests a unique mutator phenotype .
Leukemia 2010, 24 (10), 1817-1821.
Jiang XY, Grant H, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, O'Brien S, Khorashad JS, Gerrard G, Wang LH, Irving J, Wang M, Karran L, Dyer MJS, Forrest DL, Page K, Eaves CJ, Woolfson A. Analysis of BCR-ABL1 Tyrosine Kinase Domain Mutations In Primitive Chronic Myeloid Leukemia Cells Identifies a Unique Mutator Phenotype .
In: Blood: 52nd Annual Meeting of the American Society of Hematology . 2010, Orlando, Florida, USA: American Society of Hematology.
Fordham SE, Matheson EC, Scott K, Irving J, Allan JM. Cellular Response to Cytarabine Is Modulated by the DNA Mismatch Repair Pathway: Implications for Treatment of Acute Myeloid Leukemia .
In: Blood: 52nd Annual Meeting of the American Society of Hematology . 2010, Orlando, Florida, USA: American Society of Hematology.
Fordham SE, Matheson EC, Scott K, Irving J, Allan JM. Cellular Response to Cytarabine is Modulated by the DNA Mismatch Repair Pathway: Implications for Treatment of Acute Myeloid Leukemia .
In: Blood: American Society of Hematology Annual Meeting . 2010, Orlando, Florida, USA: American Society of Hematology.
Hosking FJ, Papaemmanuil E, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Allan JM, Taylor M, Tomlinson IP, Greaves M, Houlston RS. Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk .
Blood 2010, 115 (22), 4472-4477.
Rehe K, Wilson K, Bomken S, McNeill H, Stanulla M, Den Boer ML, Irving J, Heidenreich O, Vormoor J. In Acute Lymphoblastic Leukaemia, Stemness Is Frequent and Ubiquitous .
In: Blood: 52nd Annual Meeting of the American Society of Hematology . 2010, Orlando, Florida, USA: American Society of Hematology.
Rehe K, Wilson K, Bomken S, McNeill H, Stanulla M, Den Boer ML, Irving J, Heidenreich O, Vormoor J. In Acute Lymphoblastic Leukaemia, Sternness Is Frequent and Ubiquitous .
In: Blood: 52nd Annual Meeting of the American Society of Hematology . 2010, Orlando, Florida, USA: American Society of Hematology.
Hosking FJ, Leslie S, Dilthey A, Moutsianas L, Wang Y, Dobbins SE, Papaemmanuil E, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Taylor M, Greaves M, McVean G, Houlston RS. MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukaemia .
Blood 2010, 117 (5), 1633-1640.
Best A, Matheson E, Minto L, Hall AG, Irving JAE. Mismatch repair and the downstream target genes, PAX5 and Ikaros, in childhood acute lymphoblastic leukemia .
Leukemia Research 2010, 34 (8), 1098-1102.
Nicholson L, Hall AG, Redfern CP, Irving J. NF kappa B modulators in a model of glucocorticoid resistant, childhood acute lymphoblastic leukemia .
Leukemia Research 2010, 34 (10), 1366-1373.
Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Neira AG, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS. Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk .
Nature Genetics 2010, 42 (6), 492-494.
Sulong S, Moorman AV, Irving JAE, Strefford JC, Konn ZJ, Case MC, Minto L, Barber KE, Parker H, Wright SL, Stewart ARM, Bailey S, Bown NP, Hall AG, Harrison CJ. A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups .
Blood 2009, 113 (1), 100-107.
Russell LJ, Capasso M, Vater I, Akasaka T, Bernard OA, Calasanz MJ, Chandrasekaran T, Chapiro E, Gesk S, Griffiths M, Guttery DS, Haferlach C, Harder L, Heidenreich O, Irving JAE, Kearney L, Nguyen-Khac F, Machado L, Minto L, Majid A, Moorman AV, Morrison H, Rand V, Strefford JC, Schwab CJ, Tonnies H, Dyer MJ, Siebert R, Harrison CJ. Deregulated expression of cytokine receptor gene, CRLF2 , is involved in lymphoid transformation in B cell precursor acute lymphoblastic leukemia .
Blood 2009, 114 (13), 2688-2698.
Irving JAE, Jesson J, Virgo P, Case MC, Minto CLJ, Eyre L, Noel N, Johansson U, Macey M, Knotts L, Helliwell M, Davies P, Whitby L, Barnett D, Hancock J, Goulden N, Lawson S. Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting .
Haematologica 2009, 94 (6), 870-874.
Wilson K, Case M, Minto L, Bailey S, Bown N, Jesson J, Lawson S, Vormoor J, Irving J. Flow minimal residue disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+ CD38low CD19+ in B-lineage childhoood acute lymphoblastic leukemia .
Haematologica 2009, 95 (4), 679-683.
Gruber G, Carlet M, Türtscher E, Meister B, Irving J, Ploner C, Kofler R. Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis .
Leukemia 2009, 23 (4), 820-823.
Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Allan JM, Tomlinson IP, Taylor M, Greaves M, Houlston RS. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia .
Nature Genetics 2009, 41 (9), 1006-1010.
Paulsson K, An Q, Moorman AV, Parker H, Molloy G, Davies T, Griffiths MJ, Ross FM, Irving JAE, Harrison CJ, Young BD, Strefford JC. Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia .
British Journal of Haematology 2009, 144 (6), 838-847.
Brito JLR, Walker B, Jenner M, Dickens NJ, Brown NJM, Ross FM, Avramidou A, Irving JAE, Gonzalez D, Davies FE, Morgan GJ. MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells .
Haematologica 2009, 94 (1), 78-86.
Syed AA, Halpin C, Irving JAE, Unwin NC, White M, Bhopal RS, Redfern CPF, Weaver JU. A common intron 2 polymorphism of the glucocorticoid receptor gene is associated with insulin resistance in men .
Clinical Endocrinology 2008, 68 (6), 879-884.
Wilson K, Rehe K, Bomken S, Case M, Shultz L, Irving J, Vormoor J. In Childhood ALL, Both Blasts with a CD20(-/Low) and a CD20(High) Immunophenotype, Have the Ability to Transfer the Leukemia Onto Immune-Deficient NOD/Scid Y-/- Mice .
In: Blood: 50th Annual Meeting of the American Society of Hematology . 2008, San Francisco, California, USA: American Society of Hematology.
Case MC, Matheson E, Minto L, Hassan R, Harrison CJ, Bown NP, Bailey S, Vormoor J, Hall AG, Irving JAE. Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia .
Cancer Research 2008, 68 (16), 6803-6809.
Parker H, An Q, Barber K, Case MC, Davies TL, Konn Z, Stewart A, Wright S, Griffiths M, Ross FM, Moorman AV, Hall AG, Irving JAE, Harrison CJ, Strefford JC. The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1 .
Genes, Chromosomes and Cancer 2008, 47 (12), 1118-1125.
An Q, Wright SL, Konn ZJ, Matheson E, Minto L, Moorman AV, Parker H, Griffiths M, Ross FM, Davies T, Hall AG, Harrison CJ, Irving JA, Strefford JC. Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer .
Proceedings of the National Academy of Sciences of the United States of America 2008, 105 (44), 17050-17054.
Matheson EC, Hogarth LA, Case MC, Irving JAE, Hall AG. DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivo .
Carcinogenesis 2007, 28 (6), 1341-1346.
Syed, A.A., Irving, J.A.E., Redfern, C.P.F., Hall, A.G., Unwin, N.C., White, M.J.R., Bhopal, R.S., Weaver, J.U. Association of glucocorticoid receptor polymorphism A3669G in exon 9β with reduced central adiposity in women .
Obesity 2006, 14 (5), 759-764.
Sulong, S., Irving, J.A.E., Case, M.C., Minto, C.L.J., Bown, N., Bailey, S., Harrison, C., Hall, A.G. Comprehensive analysis of p16(INK4a) in childhood acute lymphoblastic leukemia reveals homozygous deletion, haploinsufficiency and acquired isodisomy at the 9p locus with intact p16(INK4a) .
Blood 2006, 108 (11).
Schmidt S, Irving JAE, Minto CLJ, Matheson E, Nicholson L, Ploner A, Parson W, Kofler A, Amort M, Erdel M, Hall AG, Kofler R. Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor .
The FASEB Journal 2006, 20 (14), E2087-E2097.
Irving, J.A.E., Minto, C.L.J., Matheson, E., Case, M.C., Bailey, S., Bown, N.P., Hassan, R., Harrison, C., Hall, A.G. Mutation in genes impacting on the RAS-RAF-MEK-ERK pathway are found at high incidence in childhood acute lymphoblastic leukemia at both diagnosis and at relapse .
Blood 2006, 108 (11), 160B-161B.
Meier, M., den Boer, M., Hall, A.G., Irving, J.A.E., Passier, M., Minto, C.L.J., van Wering, E., Janka-Schaub, G., Pieters, R. Reply to 'ATM variants and predisposition to childhood T-lineage acute lymphoblastic leukaemia' by Gumy-Pause et al. [6] .
Leukemia 2006, 20 (3), 527.
Cazzaniga G, Irving J, Citterio M, Bungaro S, Tussiwand R, Mura R, Hall AG, Biondi A. Constitutional segmental uniparental disomy in a twin pair with t(12;21) positive acute lymphoblastic leukemia characterized by the same prenatal clone and divergent clonal evolution .
In: 47th Annual Meeting of the American Society of Hematology . 2005, Atlanta, Georgia, USA: Blood: American Society of Hematology.
Velangi M, Matheson E, Hall AG, Irving JAE. Detecting mismatch repair defects in myeloma .
In: Brown RD; Ho PJ, ed. Multiple Myeloma . Totowa, N.J: Humana Press, Inc, 2005, pp.269-77.
Irving, J.A.E., Minto, C.L.J., Bailey, S., Hall, A.G. Loss of heterozygosity and somatic mutations of the Glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course .
Cancer Research 2005, 65 (21), 9712-9718.
Irving JAE, Bloodworth LC, Bown NP, Case MC, Hogarth LA, Hall AG. Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis .
Cancer Research 2005, 65 (8), 3053-3058.
Meier, M., den Boer, M., Hall, A.G., Irving, J.A.E., Passier, M., Minto, C.L.J., van Wering, E., Janka-Schaub, G., Pieters, R. Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia .
Leukemia 2005, 19 (11), 1887-1895.
Sulong, S., Case, M.C., Minto, C.L.J., Wilkins, B., Hall, A.G., Irving, J. The V617F mutation in Jak2 is not found in childhood acute lymphoblastic leukaemia .
British Journal of Haematology 2005, 130 (6), 964-965.
Velangi MR, Matheson EC, Taylor PRA, Jackson GH, Hall AG, Irving JAE. BRAF gene is not mutated in mismatch repair-proficient or -deficient plasma cell dyscrasias .
Leukemia 2004, 18 (3), 658-659.
Velangi MR, Matheson EC, Morgan GJ, Jackson GH, Taylor PRA, Hall AG, Irving JAE. DNA mismatch repair pathway defects in the pathogenesis and evolution of myeloma .
Carcinogenesis 2004, 25 (10), 1795-1803.
Syed, A.A., Irving, J.A.E., Redfern, C.P.F., Hall, A.G., Unwin, N.C., White, M., Bhopal, R., Alberti, K., Weaver, J.U. Low Prevalence of the N363S Polymorphism of the Glucocorticoid Receptor in South Asians Living in the United Kingdom .
Journal of Clinical Endocrinology and Metabolism 2004, 89 (1), 232-235.
Irving JAE, O'Brien S, Lennard A, Minto CLJ, Lin F, Hall AG. Use of Denaturing HPLC for Detection of Mutations in the BCR-ABL Kinase Domain in Patients Resistant to Imatinib .
Clinical Chemistry 2004, 50 (7), 1233-1237.
