Newcastle University

Qualifications

BM BCh MA DPhil MRCP FRCPath

Research Interests

Haematopoietic stem cell transplantation and antigen presenting cell function in graft versus host responses

Other Expertise

Chimaerism analysis of peripheral tissues

Postgraduate Supervision

Transplantation immunology

Funding

Leukaemia Research Fund Clinician Scientist 2002-2006 250K
Tyneside Leukaemia Research Association 2005-2006 31K
Action Medical Research 2005-2008 160K
LRF Bennett Senior Fellowship 2006-2009

• Pearce KF, Ahmed S, Norden J, Collin MP, Wang XN, Cornelissen JJ, Wolff D, Aubano A, Holtick U, Scheid C, Socie G, Greinix H, Holler E, Dickinson AM. Genomic Factors and biomarkers as predictors of GvHD after haematopoietic stem cell transplantation. In: 39th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT). 2013, London, UK.
• Jardine L, Hambleton S, Bigley V, Pagan S, Wang X-N, Collin M. Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands. Leukemia and Lymphoma 2013, 54(1), 167-173.
• Hugle T, O'Reilly S, Simpson R, Kraaij MD, Bigley V, Collin M, Krippner-Heidenreich A, van Laar JM. Tumor Necrosis Factor-Costimulated T Lymphocytes From Patients With Systemic Sclerosis Trigger Collagen Production in Fibroblasts. Arthritis & Rheumatism 2013, 65(2), 481-491.
• Mavin E, Atarod S, Collin M, Dickinson A, Wang X. An association between skin homing T-cells and graft-versus-host disease. In: 38th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT). 2012, Geneva, Switzerland: Nature Publishing Group.
• Verykiou S, McGovern N, Milne P, Collin M, Menon G, Haniffa M. Enhancing diagnostic sensitivity for cutaneous blastic plasmacytoid dendritic cell neoplasia. In: 92nd Annual Meeting of the British Association of Dermatologists. 2012, Birmingham, UK: Wiley-Blackwell Publishing Ltd.
• Collin M, Dickinson RE, Haniffa MA, McGovern N, Griffin H, Reynard L, Lakey J, Hambleton S, Santibanez-Koref MA, Bigley V. Evolution of Dendritic Cell, Monocyte B and NK Lymphoid (DCML) deficiency; a human primary immunodeficiency arising from GATA-2 mutation. In: European Congress of Immunology. 2012, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
• Atarod S, Turner B, Norden J, Collin M, Dickinson A. HSPA1L and HSPA1B mRNA expression in the pathogenesis of graft-versus-host disease. In: 38th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT). 2012, Geneva, Switzerland: Nature Publishing Group.
• Bigley V, Dickinson R, Gennery A, Griffin H, Haniffa M, McGovern N, Milne P, Cant A, Santibanez-Koref M, Hambleton S, Collin M. Human dendritic cell deficiency. In: 15th Biennial Meeting European Society for Immunodeficiency (ESID). 2012, Florence, Italy: Springer.
• Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, Wasan PS, Wang XN, Malinarich F, Malleret B, Larbi A, Tan P, Zhao H, Poidinger M, Pagan S, Cookson S, Dickinson R, Dimmick I, Jarrett RF, Renia L, Tam J, Song C, Connolly J, Chan JK, Gehring A, Bertoletti A, Collin M, Ginhoux F. Human Tissues Contain CD141(hi) Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103(+) Nonlymphoid Dendritic Cells. Immunity 2012, 37(1), 60-73.
• Haniffa M, Shin A, Bigley V, Teo P, See P, Wasan P, McGovern N, Wang XN, Malinarich F, Malleret B, Larbi A, Poidinger M, Jarrett R, Connolly J, Chan J, Gehring A, Bertoletti A, Collin M, Ginhoux F. Identification of a novel cross-presenting migratory dendritic cell in the human skin: the key cell for rational vaccine strategies. In: 92nd Annual Meeting of the British Association of Dermatologists. 2012, Birmingham, UK: Wiley-Blackwell Publishing Ltd.
• Thaventhiran JE, McGovern N, Dickinson R, Bigley V, Doffinger R, Kumararatne D, Chee R, Seneviratne S, Grimbacher B, Collin M, Morris E. Identification of GATA-2 mutations using a simple screening procedure in patients with Papilloma virus infections. In: 15th Biennial Meeting European Society for Immunodeficiency (ESID). 2012, Florence, Italy: Springer.
• Haniffa M, Shin A, Bigley V, Teo P, See P, Wasan P, McGovern N, Wang XN, Malinarich F, Malleret B, Poidinger M, Gehring A, Bertoletti A, Collin M, Ginhoux F. Identification of the human cross-presenting migratory dendritic cell. In: Meeting of the British Society for Investigative Dermatology. 2012, Exeter, UK: Wiley-Blackwell Publishing Ltd.
• Maggina P, Stroud C, Bourne H, Cole T, Collin M, Jackson G, Flood T, Barge D, Mansfield J, Hodges S, Spickett G, Gennery A. Idiopathic colitis following haematopoietic stem cell transplantation for chronic granulomatous disease: Three cases at a national centre. In: 15th Biennial Meeting European Society for Immunodeficiency (ESID). 2012, Florence, Italy: Springer.
• Atarod S, Cope W, Norden J, Collin M, Dickinson AM. miR-146a expression in graft-versus-host disease. In: 38th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT). 2012, Geneva, Switzerland: Nature Publishing Group.
• Lane J, Slatter M, Nademi Z, Tierney P, Barge D, Hambleton S, Flood T, Cant A, Abinun M, Jackson G, Collin M, Gennery A. Outcome of haematopoietic stem cell transplantation in patients with chronic granulomatous disease at a national centre. In: 38th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT). 2012, Geneva, Switzerland: Nature Publishing Group.
• Sturgess K, Slatter M, Bigley V, Dickinson R, Haniffa M, McGovern N, Jardine L, Jackson G, Cant A, Gennery A, Hambleton S, Collin M. Reduced-intensity haematopoietic stem cell transplant rescues immune function and corrects pulmonary alveolar proteinosis in DCML deficiency/GATA 2 mutation. In: 38th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT). 2012, Geneva, Switzerland: Nature Publishing Group.
• Mavin E, Ahmed SS, O'Boyle G, Turner B, Douglass S, Collin M, Ali S, Dickinson A, Wang X-N. Regulatory T Cells Inhibit CD8+ T-Cell Tissue Invasion in Human Skin Graft-Versus-Host Reactions. Transplantation 2012, 94(5), 456-464.
• Atarod S, Cope W, Norden J, Collin M, Dickinson AM. Role of miR-146a-5p in Graft-versus-Host Disease. In: European Congress of Immunology. 2012, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
• Haniffa M, Shin A, Bigley V, McGovern N, Wang XN, Teo P, Sng D, Won JM, Marinarich FG, Malleret B, See P, Larbi A, Zhou H, Poidinger M, Pagan S, Cookson S, Dickinson R, Connolly J, Gehring A, Bertoletti A, Collin M, Ginhoux F. CD141(+) human migratory dendritic cells are homologous to murine CD103+dendritic cells and excel at exogenous antigen cross-presentation. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Bigley V, Collin M. Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome. Haematologica 2011, 96(8), 1081-1083.
• Dickinson RE, Collin M. EXOME SEQUENCING IDENTIFIES GATA-2 MUTATION AS THE CAUSE OF DENDRITIC CELL, MONOCYTE, B AND NK LYMPHOID DEFICIENCY. Blood 2011. Submitted.
• Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M. Exome sequencing identifies GATA-2 mutation as the cause of the dendritic cell, monocyte, B and NK lymphoid deficiency. Blood 2011, 118(10), 2656-2658.
• Moses SE, Osborne W, Valappil M, Collin M, Lee D, Waugh S, Jackson G, Parry CM, Crowley B. Extensive oral herpes simplex virus type 1 infection in a haematopoietic stem cell transplant recipient not responding to aciclovir. Journal of Clinical Virology 2011, 52(2), 67-69.
• Dickinson RE, Bigley V, Griffin H, Lakey JH, McGovern N, Chua I, Wallis J, Hambleton S, Santibanez-Koref M, Collin M. Human dendritic cell deficiency is caused by GATA-2 mutation. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Collin M, Bigley V, Haniffa M, Hambleton S. Human dendritic cell deficiency: the missing ID?. Nature Reviews Immunology 2011, 11(9), 575-583.
• McGovern N, Bigley V, Allen C, Haniffa M, Wang XN, Dickinson R, Pagan S, Windebank K, McClain K, Ginhoux F, Merad M, Collin M. Human Langerin plus dendritic cells are independent of epithelial Langerhans cells; a novel perspective on Langerhans cell histiocytosis. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Hambleton S, Salem S, Bustamente J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez C, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong X, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova J-L, Gros P. IRF8 Mutations and Human Dendritic-Cell Immunodeficiency. New England Journal of Medicine 2011, 365(2), 127-138.
• Shamim Z, Ryder LP, Christensen IJ, Toubert A, Norden J, Collin M, Jackson G, Dickinson AM, Muller K. Prognostic Significance of Interleukin-7 Receptor-alpha Gene Polymorphisms in Allogeneic Stem-Cell Transplantation: A Confirmatory Study. Transplantation 2011, 91(7), 731-736.
• Sturgess K, Slatter M, Bigley V, Haniffa M, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Chua I, Wallis J, Lordan J, Morgan C, Cant A, Gennery A, Edmondson R, Bacon C, Black F, Kirkham N, Jackson GH, Hambleton S, Collin MP. Reduced Intensity Hematopoietic Stem Cell Transplant Rescues Immune Function and Corrects Pulmonary Alveolar Proteinosis in DCML Deficiency/GATA 2 Mutation. In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.
• Bigley V, Haniffa M, Doulatov S, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Dimmick I, Chua I, Wallis J, Lordan J, Morgan C, Kumararatne DS, Doffinger R, van der Burg M, van Dongen J, Cant A, Dick JE, Hambleton S, Collin M. The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. Journal of Experimental Medicine 2011, 208(2), 227-234.
• Ingersoll M, Spanbroek R, Lottaz C, Gautier E, Frankenberger M, Hoffmann R, Lang R, Haniffa M, Collin M, Tacke F, Habenicht A, Ziegler-Heitbrock L, Randolph G. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 2010, 115(3), e10-e19.
• Bigley V, Spence LE, Collin M. Connecting the dots: monocyte/DC and NK subsets in human peripheral blood. Blood 2010, 116(15), 2859-2860.
• Chakraverty R, Orti G, Roughton M, Shen J, Fielding A, Kottaridis P, Milligan D, Collin M, Crawley C, Johnson P, Clark A, Parker A, Bloor A, Pettengell R, Snowden J, Pettitt A, Clark R, Hale G, Peggs K, Thomson K, Morris E, Mackinnon S. Impact of in vivo alemtuzumab dose before reduced intensity conditioning and HLA-identical sibling stem cell transplantation: pharmacokinetics, GVHD, and immune reconstitution. Blood 2010, 116(16), 3080-3088.
• Harries V, Dickinson R, Bigley V, Collin M. The Equilibration of Peripheral Blood and Tissue CD3+T Cell Engraftment Is Influenced by Graft Versus Host Disease Following Reduced Intensity Conditioning Stem Cell Transplantation. In: Blood: American Society of Hematology Annual Meeting. 2010, Orlando, Florida, USA: American Society of Hematology.
• Malladi R, Peniket A, Littlewood T, Towlson K, Pearce R, Yin J, Cavenagh J, Craddock C, Orchard K, Olavarria E, McQuaker G, Collin M, Marks D. Alemtuzumab markedly reduces chronic GVHD without affecting overall survival in reduced-intensity conditioning sibling allo-SCT for adults with AML. Bone Marrow Transplantation 2009, 43(9), 709-715.
• Haniff M, Ginhoux F, Wang XN, Bigley V, Abel M, Dimmick I, Bullock S, Grisotto M, Booth T, Taub P, Hilkens C, Merad M, Collin M. Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation. Journal of Experimental Medicine 2009, 206(2), 371-385.
• Haniffa MA, Collin MP, Buckley CD, Dazzi F. Mesenchymal stem cells: The fibroblasts' new clothes?. Haematologica 2009, 94(2), 258-263.
• Wang XN, Haniffa MA, Holtick U, Collin MP, Jackson G, Hilkens CMU, Holler E, Edinger M, Hoffmann P, Dickinson AM. Regulatory T-Cell Suppression of CD8(+) T-Cell-Mediated Graft-Versus-Host Reaction Requires Their Presence During Priming. Transplantation 2009, 88(2), 188-197.
• Haniffa MA, Ginhoux F, Abel M, Alshemali S, Bullock S, Taub P, Merad M, Collin MP. Human factor XIIIa+ melanophages outlive all other cutaneous antigen-presenting cells, including Langerhans cells, after haematopoietic transplantation. In: British Journal of Dermatology: Annual Meeting of the British Society for Investigative Dermatology. 2008, Oxford, UK: Wiley-Blackwell Publishing Ltd.
• Merad M, Ginhoux F, Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nature Reviews Immunology 2008, 8(12), 935-947.
• Haniffa MA, Wang XN, Holtick U, Rae M, Isaacs JD, Dickinson AM, Hilkens CM, Collin MP. Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells. Journal of Immunology 2007, 179(3), 1595-1604.
• Collin MP, Hart DNJ, Jackson GH, Cook G, Cavet J, Mackinnon S, Middleton PG, Dickinson AM. The fate of human Langerhans cells in hematopoietic stem cell transplantation. Journal of Experimental Medicine 2006, 203(1), 27-33.
• Collin MP, Munster D, Clark G, Wang X-N, Dickinson AM, Hart DN. In vitro depletion of tissue-derived dendritic cells by CMRF-44 antibody and alemtuzumab: Implications for the control of graft-versus-host disease. Transplantation 2005, 79(6), 722-725.