Newcastle University

Introduction

Please visit my home-page for further details www.staff.ncl.ac.uk/n.j.morris/

Roles and Responsibilities

Board of Studies (biomedical sciences)
Board of Examiners (biomedical sciences)
Curriculum Committee Biochemistry and Genetics (Chair)
Staff Student Committee Biochemistry and Genetics (Chair)
Phase 2 advisor (Biochemistry)
Academic Skills Advisor
Blackboard Steering Group (Chair)
eLearning Group
Board of Studies for Certificate in Advanced Studies in Academic Practice (CASAP)
Board of Examiners for Certificate in Advanced Studies in Academic Practice (CASAP)
Faculty Programme Liaison Officer for Certificate in Advanced Studies in Academic Practice (CASAP)

Qualifications

MSc
PhD

Previous Positions

1994 - 1998 Post-doctoral research fellow with Dr G.E. Lienhard, Biochemistry Department, Dartmouth Medical School, Hanover, New Hampshire, 03755, USA

1990 - 1993 PhD students with Prof. Miles D. Houslay, Biochemistry Department, Glasgow University, Glasgow, Scotland.

1987 - 1990 Research assistant to Prof N. N. Osborne, Nuffield Laboratory of Ophthalmology, Oxford University, Oxford

Memberships

Biochemical Society (1990 - to present).
British Electrophoresis Society (2000 - present)

Languages

Computing: C, objective C (Cocoa), php, mysql, Javascript

Research Interests

Proteomics, cellular trafficking and signalling, insulin signalling, bioinformatics. (also, see my lab home page [www.staff.ncl.ac.uk/n.j.morris/])

Other Expertise

Computer programming (php, MySQL, Objective C, javascript, AJAX), web page authoring.

Current Work

Please see www.staff.ncl.ac.uk/n.j.morris/

Research Roles

Consultant on a number of bioinformatic and proteomics projects.
Established the proteomics facility at Newcastle University.
Established the bioinformatics facility (Bioinformatics Support Unit (BSU)) at Newcastle University.

Postgraduate Supervision

Proteomics, bioinformatics, insulin signalling and intracellular transport of proteins

Esteem Indicators

Biochemical Society (summer studentship grant reviews)

Funding

EU TRANS-NET
BBSRC Project Grant 2004 - 2007
EU FP6 NOFORISK co-supervisor 2004 - 2006
Wellcome Trust Project Grant 2003 - 2005 (£180,000)
BBSRC Case Award 2003 - 2006
Royal Society 2000 (£9,800)

Industrial Relevance

BBSRC Case Award with Nonlinear Dynamics, Newcastle

Undergraduate Teaching

Please see the teaching section on my website for further details: www.staff.ncl.ac.uk/n.j.morris/lectures/

• Stocki P, Wang XN, Morris NJ, Dickinson AM. HSP70 Natively and Specifically Associates with an N-terminal Dermcidin-derived Peptide That Contains an HLA-A*03 Antigenic Epitope. Journal of Biological Chemistry 2011, 286(14), 12803-12811.
• Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP. Measuring mucus thickness in reef corals using a technique devised for vertebrate applications. Marine Biology 2010, 157(2), 261-267.
• Emami K, Morris NJ, Cockell SJ, Golebiowska G, Shu QY, Gatehouse AMR. Changes in Protein Expression Profiles between a Low Phytic Acid Rice (Oryza sativa L. Ssp japonica) Line and Its Parental Line: A Proteomic and Bioinformatic Approach. Journal of Agricultural and Food Chemistry 2010, 58(11), 6912-6922.
• Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP. Coral mucus: the properties of its constituent mucins. Biomacromolecules 2010, 11(4), 883-888.
• Gibson F, Anderson L, Babnigg G, Baker M, Berth M, Binz P-A, Borthwick A, Cash P, Day BW, Friedman DB, Garland D, Gutstein HB, Hoogland C, Jones NA, Khan A, Klose J, Lamond AI, Lemkin PF, Lilley KS, Minden J, Morris NJ, Paton NW, Pisano MR, Prime JE, Rabilloud T, Stead DA, Taylor CF, Voshol H, Wipat A, Jones AR. Guidelines for reporting the use of gel electrophoresis in proteomics. Nature Biotechnology 2008, 26(8), 863-864.
• McComb CM, Clark EL, Padget K, Harvey J, Morris NJ, Austin CA. Bioinformatic analysis of topoisomerase II binding sites. In: 30th Annual Meeting of the United Kingdom Environmental Mutagen Society. 2007, University of Cardiff, UK: Mutagenesis: Oxford University Press.
• Litherland GJ, Morris NJ, Walker M, Yeaman SJ. Role of glycogen content in insulin resistance in human muscle cells. Journal of Cellular Physiology 2007, 211(2), 344-352.
• Gibson F, Wipat A, Pocock M, Morris N. GELI: a data model for the representation of a gel electrophoresis experiment. Newcastle upon Tyne:School of Computing Science, University of Newcastle upon Tyne,2006.
• McGarry K, Garfield S, Morris N. Recent trends in knowledge and data integration for the life sciences. Expert Systems 2006, 23(5), 330-341.
• Perera HKI, Clarke M, Morris NJ, Hong W, Chamberlain LH, Gould GW. Syntaxin 6 regulates Glut4 trafficking in 3T3-L1 adipocytes. Molecular Biology of the Cell 2003, 14(7), 2946-2958.
• N. J. Morris, S. A. Ross, J. M. Neveu, W. S. Lane and G. E. Lienhard. Cloning and characterization of a 22 kDa protein from rat adipocytes: a new member of the reticulon family. Biochimica Et Biophysica Acta-Molecular Cell Research 1999, 1450, 68-76.
• N. J. Morris, S. A. Ross, J. M. Neveu, W. S. Lane and G. E. Lienhard. Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains. Biochimica Et Biophysica Acta-Protein Structure and Molecular Enzymology 1999, 1431, 525-530.
• N. J. Morris, S. A. Ross, W. S. Lane, S. K. Moestrup, C. M. Petersen, S. R. Keller and G. E. Lienhard. Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes. Journal of Biological Chemistry 1998, 273, 3582-3587.
• J. J. Herbst, S. A. Ross, H. M. Scott, S. A. Bobin, N. J. Morris, G. E. Lienhard and S. R. Keller. Insulin stimulates cell surface aminopeptidase activity toward vasopressin in adipocytes. American Journal of Physiology-Endocrinology and Metabolism 1997, 35, E600-E606.
• N. J. Morris, A. Ducret, R. Aebersold, S. A. Ross, S. R. Keller and G. E. Lienhard. Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane. Journal of Biological Chemistry 1997, 272, 9388-9392.
• S. A. Ross, H. M. Scott, N. J. Morris, W. Y. Leung, F. Mao, G. E. Lienhard and S. R. Keller. Characterization of the insulin-regulated membrane aminopeptidase in 3T3-L1 adipocytes. Journal of Biological Chemistry 1996, 271, 3328-3332.
• S. A. Ross, B. E. Lavan, N. J. Morris, J. J. Herbst, S. R. Keller and G. E. Lienhard. Increased sequestration of the insulin-regulated aminopeptidase VP165 in differentiated 3T3-L1 cells. Molecular Biology of the Cell 1996, 7, 2576-2576.
• Morris N.J., Bushfield M. and Houslay M.D. Streptozotocin-induced diabetes elicits the phosphorylation of hepatocyte Gi2 alpha at the protein kinase C site but not at the protein kinase A-controlled site. Biochem. J. 1996, 315, 417-420.
• Morris NJ, Young P, Houslay MD. Insulin inhibits the phosphorylation of alpha-Gi-2 in intact hepatocytes.. Biochemical Journal 1995, 308, 693-696.
• Morris NJ, Bushfield M, Lavan BE, Houslay MD. Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein Gi-2 occurs in rat hepatocytes. Biochemical Journal 1994, 301(3), 693-702.
• Houslay MD, Morris NJ, Savage A, Marker A, Bushfield M. Regulation of hepatocyte adenylate cyclase by amylin and CGRP: A single receptor displaying apparent negative co-operativity towards CGRP and simple saturation kinetics for amylin, a requirement for phosphodiesterase inhibition to observe elevated hepatocyte cyclic AMP levels and the phosphorylation of G_i-2. Journal of Cellular Biochemistry 1994, 55(S1994A), 66-82.
• Bushfield M, Savage A, Morris NJ, Houslay MD. A mnemonical or negative co-operativity model for the activation of adenylyl cyclase by a common G-protein coupled CGRP/amylin receptor. Biochemical Journal 1993, 293(1), 229-236.
• Osborne NN, Barnett NL, Morris NJ, Huang FL. The occurrence of three isoenzymes of protein kinase C (alpha, beta and gamma) in retinas of different species.. Brain Research 1992, 570(1-2), 161-166.
• Osborne NN, Barnett NL, Morris NJ. DARPP-32 like protein in specific snail (Helix aspersa) neurones. Histochemistry 1991, 95(4), 413-417.
• Osborne NN, Broyden NJ, Barnett NL, Morris NJ. Protein kinase C (α and β) immunoreactivity in rabbit and rat retina. Effect of phorbol esters and transmitter agonists on immunoreactivity and the translocation of the enzyme from cytosolic to membrane compartments.. Journal of Neurochemistry 1991, 57(2), 594-604.