Dr Peter MiddletonLecturer
Email: peter.middleton@ncl.ac.uk Telephone: +44 (0) 191 222 5606 Address: Institute of Cellular Medicine (Haematological Sciences)
Cavanagh G, Chapman CE, Carter V, Dickinson AM, Middleton PG. Donor CD31 genotype impacts on transplant complications after human leukocyte antigen-matched sibling allogeneic bone marrow transplantation .
Transplantation 2005,79 5 602-605.
Forrest IA, Nicholson L, Platt R, Ward C, Dark JH, Middleton PG, Corris PA. Genetic polymorphisms and bronchiolitis obliterans syndrome post lung transplantation .
In: Journal of Heart and Lung Transplantation: The International Society for Heart and Lung Transplantation Twenty-Fifth Anniversary Meeting and Scientific Sessions . 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
Dickinson AM, Wang X-N, Stark G, Cullup H, Jarvis M, Middleton PG. Beyond HLA-typing: Genetic polymorphisms predicting transplant outcome .
In: Apperley, J.F., Gluckman, E., Gratwohl, A, ed. The EBMT Handbook - Blood and Marrow Transplantation . Paris, France: European School of Haematology, 2004.
Spink CF, Keen LJ, Middleton PG, Bidwell JL. Discrimination of suballeles present at TNFd microsatellite locus using induced heteroduplex analysis .
Genes and Immunity 2004,5 1 76-79.
Dickinson AM, Middleton PG, Rocha V, Gluckman E, Holler E. Genetic polymorphisms predicting the outcome of bone marrow transplants .127 5 479-490.
Forrest IA, Platt RE, Nicholson L, Pritchard G, Murphy D, Ward C, Corris PA, Middleton PG. Genotypic risk factors for the development of the bronchiolitis oblitererans syndrome (BOS) after lung transplantation .
In: Winter Meeting of the British Thoracic Society . 2004, London: Thorax: BMJ Publishing Group.
Perrow K, Donaldson PT, Middleton PG, Taylor JJ. A 117bp deletion in intron 2 of the Human Caspase-8 Gene (CASP8) .
Immunogenetics 2003. Submitted.
Middleton PG, Dickinson AM, Jarvis M, Cavet J, Cullup H, Jackson GH. Clinical and genotypic risk factors for GvHD are modulated by prophylaxis: A multicentre cohort study of HLA matched sib-allo BMT .
In: Genes and Immunity: 17th European Histocompatability Conference . 2003, Baden, Germany: Nature Publishing Group.
Dickinson AM, Stark G, Cullup H, Jarvis M, Wang XN, Middleton PG. Cytokine Gene Polymorphism in Transplantation .
Hematopoietic Stem Cells Research and Clinical Applications 2003, European School of Haematology .
Middleton PG, Norden J, Cullup H, Cavet J, Jackson GH, Taylor PRA, Dickinson AM. Oestrogen receptor α gene polymorphism associates with occurrence of graft-versus-host disease and reduced survival in HLA-matched sib-allo BMT .
Bone Marrow Transplantation 2003, 32 (1), 41-47.
Cullup H, Dickinson AM, Cavet J, Jackson GH, Middleton PG. Polymorphisms of interleukin-1α constitute independent risk factors for chronic graft-versus-host disease after allogeneic bone marrow transplantation .
British Journal of Haematology 2003,122 5 778-787.
Cavanagh G, Middleton P, Dickinson A, Chapman C. Pre-treatment of human lymphocytes with CD31 peptide inhibits cellular proliferation in mixed lymphocyte culture .
In: Genes and Immunity: 17th European Histocompatability Conference . 2003, Baden, Germany: Nature Publishing Group.
He, L., Luo, L., Proctor, S. J., Middleton, P. G., Blakely, E. L., Taylor, R. W., Turnbull, D. M. Somatic mitochondrial DNA mutations in adult-onset leukaemia .
Leukemia 2003, 17 (12), 2487-2491.
Stark, G. L., Dickinson, A. M., Jackson, G. H., Taylor, P. R. A., Proctor, S. J., Middleton, P. G. Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation .
Transplantation 2003, 76 (12), 1742-1749.
Battiwalla M, Cavet J, Hensel N, Cullup H, Dickinson A, Nakamura R, Follman D, Childs R, Middleton P, Barrett AJ. Donor IL-1 Ra gene polymorphisms affect in vitro and in vivo responses to CMV antigen .
In: Blood: 44th Annual Meeting of the American Society of Hematology . 2002, Philadelphia, Pennsylvania, USA: American Society of Hematology.
Dickinson AM, Cavet J, Cullup H, Wang XN, Jarvis M, Sviland L, Middleton PG. Predicting outcome in hematological stem cell transplantation .50 6 371-378.
Kogler G, Middleton PG, Wilke M, Rocha V, Esendam B, Enczmann J, Wernet P, Gluckman E, Querol S, Lecchi L, Goulmy E, Dickinson AM. Recipient cytokine genotypes for TNF-alpha and IL-10 and the minor histocompatibility antigens HY and CD31 codon 125 are not associated with occurrence or severity of acute GVHD in unrelated cord blood transplantation - A retrospective analysis .
Transplantation 2002, 74 (8), 1167-1175.
Levett DL, Middleton PG, Cole M, Reid MM. A demographic study of the clinical significance of minimal residual disease in children with acute lymphoblastic leukemia .
Medical and Pediatric Oncology 2001, 36 (3), 365-371.
McCartney, H., Martin, A., Middleton, P.G., Tilby, M.J. Antibody recognition of melphalan adducts characterized using immobilized DNA: Enhanced alkylation of G-rich regions in cells compared to in vitro .
Chemical Research in Toxicology 2001, 14 (1), 71-81.
Battiwalla M, Middleton PG, Childs RW, Neylon AJ, Barrett J. Do adverse cytokine expression profiles in nonmyeloablative stem cell transplant (NST) recipients play a lesser role than in standard transplantation? .
In: Blood: 43rd Annual Meeting of The American Society of Hematology . 2001, Orlando, Florida, USA: American Society of Hematology.
Cullup H, Dickinson AM, Jackson GH, Taylor PR, Cavet J, Middleton PG. Donor interleukin 1 receptor antagonist genotype associated with acute graft-versus-host disease in human leucocyte antigen-matched sibling allogeneic transplants .
British Journal of Haematology 2001, 113 (3), 807-813.
Dickinson AM, Cavet J, Cullup H, Wang XN, Sviland L, Middleton PG. GvHD risk assessment in hematopoietic stem cell transplantation: Role of cytokine gene polymorphisms and an In Vitro human skin explant model .
Human Immunology 2001,62 11 1266-1276.
Neylon AJ, O'Brien SG, Szydlo R, Brookes PA, Goldman JM, Middleton PG. IL-4 gene polymorphism and outcome following sibling allogeneic bone marrow transplant .
In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH) . 2001, Orlando, Florida, USA: American Society of Hematology.
Cavet J, Dickinson AM, Norden J, Taylor PRA, Jackson GH, Middleton PG. Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation .
Blood 2001, 98 (5), 1594-1600.
Baker KS, Cavet J, DeFor T, Costello S, Norden J, Middleton PG, Davies SM. Interleukin-10 (IL-10) gene polymorphisms and IL-10 production as predictors of transplant related complications in unrelated donor transplant recipients .
In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH) . 2001, Orlando, Florida, USA: American Society of Hematology.
Coulthard, S., Rabello, C., Robson, J., Howell, C., Minto, L., Middleton, P., Gandhi, M., Jackson, G., McLelland, J., O'Brien, H., Smith, S., Reid, M., Pearson, A., Hall, A. A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations .
British Journal of Haematology 2000, 110 (3), 599-604.
Dickinson AM, Cullup H, Cavet J, Middleton PG. Cytokines and Chemokines .
Immunobiology of Transplantation: From Basic Science to Practical Medicine 2000, European School of Haematology (Euroconference II) .
Cullup H, Dickinson AM, Jackson GH, Taylor PR, Cavet J, Middleton PG. Donor interleukin-1 receptor antagonist genotype associated with acute graft versus host disease in HLA-matched sibling allogeneic transplants .
In: BLOOD . 2000.
Haire WD, Cavet J, Pavletic SZ, Tarantolo SR, Norden J, Middleton PG. Tumor necrosis factor d3 allele predicts for organ dysfunction after allogeneic blood stem cell transplantation (ABSCT) .
In: BLOOD . 2000.
Mainou-Fowler T, Dickinson AM, Taylor PRA, Mounter P, Jack F, Proctor SJ, Norden J, Middleton PG. Tumour necrosis factor gene polymorphisms in lymphoproliferative disease .
Leukemia and Lymphoma 2000, 38 (5-6), 547-552.
Cavet J, Dickinson AM, Norden J, Jackson GH, Taylor PRA, Middleton PG. Vitamin D receptor gene polymorphism associates with acute graft versus host disease and survival in HLA-matched sibling allogeneic bone marrow transplantation .
In: BLOOD . 2000.
