Dr Simon Wilkinson
Staff Scientist

  • Email: simon.wilkinson@ncl.ac.uk
  • Telephone: +44 (0) 191 208 8537
  • Address: Medical Toxicology Centre
    Wolfson Unit
    School of Clinical & Laboratory Sciences
    Medical School
    University of Newcastle upon Tyne
    NE2 4HH

Roles and Responsibilities

Research - As Prinicipal Investigator: HPA core research funding and HPA-funded studentship. As project manager: Home Office funded research project (biomonitoring). As contributor and co-applicant: DEFRA/PSD funded research contract, Home office fudned project (dermal absorption).
Teaching - undergraduate teaching on Pharmacology module, supervision of under- and postgraduate researchers
Service - advice on public health aspects of environmental chemical exposure (acute incidents)
Wolfson Unit radiation protection supervisor and information security officer

Qualifications

BSc Applied Biology (upper second class honours) CNAA
PhD (Univ Central Lancs)

Previous Positions

Scientific Toxicologist, Chemical Hazards and Poisons Division (Newcastle), Health Protection Agency (2004-2006)
Research Associate, School of Clinical and Laboratory Sciences, University of Newcastle (2001-2004)
Research Associate, Dept of Environmental and Occupational Medicine, University of Newcastle (1999-2000)

Memberships

British Toxicology Society (since 1999)
Committee member of Skin Forum since 2003
UK Safety Science Forum (secretary)

Languages

Some written and spoken French and German

Research Interests

Dermal absorption, dermal metabolism and dermal toxicology
In vitro methods for dermal absorption and metabolism
Dermal absorption of components from liquid mixtures
Detection of exposure during accidental and deliberate chemical release

Other Expertise

Predictive modelling for dermal absorption and metabolism

Current Work

Dermal absorption and metabolism of mono- and polyaromatic hydrocarbons in vitro
Rapid methods for detection of chemical exposure during chemical incidents
Prediction of dermal absorption of chemicals of concern using mathematical modelling and other approaches

Future Research

Influence of xenobiotics on dermal endobiotic metabolic pathways
Influence of xenobiotics on response to oxidative stress in skin
Proteomic markers of chemical exposure

Research Roles

Investigator on HPA-funded research studentship
Project manager on Home Office project grant and HPA-funded core research project
Co-applicant on Home Office project grants and DEFRA funded research project

Postgraduate Supervision

Currently lead supervisor for PhD student
Co-supervisor for PhD student

Esteem Indicators

Founder member of In vitro percutaneous absorption technique Expert Users' Group
Five invited book chapters published or in submission

Funding

HPA Studentship (2005-2008) £60,000
DEFRA/PSD project grant (2005-2006) £80,000 (Joint with Prof Faith Williams)
HPA core funding (2006-2009 rolling) £TBA (Joint with Prof Faith Williams and Prof Peter Blain
HSE studentship (2002-2005) £100,000 (Joint with Prof Faith Williams)

Industrial Relevance

Dermal absorption of chemicals in the workplace and consequences for health
Biological monitoring methods for early detection of exposure

Undergraduate Teaching

PED3011 Toxicology
Undegraduate research project supervision (Pharmacology and Biomedical Sciences)

Postgraduate Teaching

MRes Drug Discovery