Publication:

Differential selection of acridine resistance mutations in human DNA topoisomerase II beta is dependent on the acridine structure (2007)

Author(s): Leontiou C, Watters GP, Gilroy KL, Heslop P, Cowell IG, Craig K, Lightowlers RN, Lakey JH, Austin CA

      • Date: 01-04-2007
      • Journal: Molecular Pharmacology
      • Volume: 71
      • Issue: 4
      • Pages: 1006-1014
      • Publisher: American Society for Pharmacology and Experimental Therapeutics
      • Publication type: Article
      • Bibliographic status: Published

      Keywords: METAL-ION MECHANISM NON-CYCLING CELLS CLEAVABLE COMPLEXES DRUG-RESISTANCE POINT MUTATION AMSACRINE ALPHA LEUKEMIA ANTITUMOR DOMAIN

      Staff

      Dr Ian Cowell
      Staff Scientist

      Professor Jeremy Lakey
      Professor of Structural Biochemistry

      Professor Robert Lightowlers
      Director, ICaMB and Professor of Molecular Neuroscience