Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia (2004)

Author(s): Harrison CJ, Moorman AV, Broadfield ZJ, Cheung KL, Harris RL, Jalali GR, Robinson HM, Barber KE, Richards SM, Mitchell CD, Eden TO, Hann IM, Hill FG, Kinsey SE, Gibson BES, Lilleyman J, Vora A, Goldstone AH, Franklin IM, Durrant J, Martineau M

  • : Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia

Abstract: This study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest series of patients with hypodiploidy (<46 chromosomes) yet reported. The incidence of 5% was independent of age. Patients were subdivided by the number of chromosomes; near-haploidy (23-29 chromosomes), low hypodiploidy (33-39 chromosomes) and high hypodiploidy (42-45 chromosomes). The near-haploid and low hypodiploid groups were characterized by their chromosomal gains and a doubled hyperdiploid population. Structural abnormalities were more frequent in the low hypodiploid group. Near-haploidy was restricted to children of median age 7 years (range 2-15) whereas low hypodiploidy occurred in an older group of median age 15 years (range 9-54). Patients with 42-45 chromosomes were characterized by complex karyotypes involving chromosomes 7, 9 and 12. The features shared by the few patients with 42-44 chromosomes and the large number with 45 justified their inclusion in the same group. Survival analysis showed a poor outcome for the near-haploid and low hypodiploid groups compared to those with 42-45 chromosomes. Thus cytogenetics, or at least a clear definition of the modal chromosome number, is essential at diagnosis in order to stratify patients with hypodiploidy into the appropriate risk group for treatment.

Notes: Childhood and Adult Leukaemia Working Parties Journal Article Research Support, Non-U.S. Gov't England

  • Short Title: Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia
  • Alternate Journal: British journal of haematology
  • Date: 19-04-2004
  • Journal: British Journal of Haematology
  • Volume: 125
  • Issue: 5
  • Pages: 552-559
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Adolescent Adult *Aneuploidy Child Chromosomes, Human/*genetics Disease-Free Survival Female Follow-Up Studies Humans Karyotyping Male Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics Prognosis Survival Analysis


Professor Anthony Moorman
Professor of Genetic Epidemiology