Publication:

t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia (2004)

Author(s): Robinson HM, Taylor KE, Jalali GR, Cheung KL, Harrison CJ, Moorman AV

  • : t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia

Abstract: The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute lymphoblastic leukemia who have a cytogenetically identical translocation with different breakpoints at the molecular level. Fluorescence in situ hybridization with locus-specific probes confirmed the involvement of the IGH@ gene but showed that the breakpoint on 19q13 lay outside the region documented in t(14;19)(q32;q13)-positive chronic lymphocytic leukemia. This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia.

Notes: Journal Article Research Support, Non-U.S. Gov't United States

  • Type of Article: Brief communication
  • Short Title: t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia
  • Alternate Journal: Genes, chromosomes & cancer
  • Date: 17-10-2003
  • Journal: Genes, Chromosomes and Cancer
  • Volume: 39
  • Issue: 1
  • Pages: 88-92
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Adolescent Adult Child Chromosomes, Human, Pair 14/*genetics Chromosomes, Human, Pair 19/*genetics Female Humans Male Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics Translocation, Genetic/genetics

Staff

Professor Anthony Moorman
Professor of Genetic Epidemiology