Pushing and pulling in prokaryotic DNA segregation (2010)

Author(s): Gerdes K, Howard M, Szardenings F

    Abstract: In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of par locus, which is present on many plasmids and most bacterial chromosomes, encodes a P loop ATPase (ParA) that distributes plasmids equidistant from one another on the bacterial nucleoid. A third type of par locus encodes a tubulin homolog (TubZ) that forms cytoskeletal filaments that move rapidly with treadmill dynamics.

      • Date: 10-06-2010
      • Journal: Cell
      • Volume: 141
      • Issue: 6
      • Pages: 927-42
      • Publisher: Cell Press
      • Publication type: Article
      • Bibliographic status: Published