SAFB1 and SAFB2 mediated transcriptional repression: relevance in cancer (2012)

Author(s): Hong EA, Gautrey HL, Elliott DJ, Tyson-Capper AJ

    Abstract: Scaffold attachment factor B1 (SAFB1) and a second family member, SAFB2 are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors have been put forward based on well-described roles in transcriptional repression. This review summarises the current knowledge of SAFB1 and SAFB2 in transcriptional repression with relevance to cancer.

      • Date: 01-08-2012
      • Journal: Biochemical Society Transactions
      • Volume: 40
      • Issue: 4
      • Pages: 826-830
      • Publication type: Review
      • Bibliographic status: Published

      Professor David Elliott
      Professor of Genetics

      Dr Alison Tyson-Capper
      Faculty Postgraduate Tutor (Associate Dean); Senior Lecturer