Regulation of gene expression by the RNA-binding protein Sam68 in cancer (2008)

Author(s): Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ

    Abstract: Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.

    • Type of Article: Review
    • Date: 01-06-2008
    • Journal: Biochemical Society Transactions
    • Volume: 36
    • Issue: 3
    • Pages: 505-507
    • Publisher: Portland Press Ltd.
    • Publication type: Article
    • Bibliographic status: Published

    Keywords: cancer, cell cycle, RNA processing, signal transducer and activator of RNA (STAR), Src-associated in mitosis 68 kDa (Sam68), transcription


    Professor David Elliott
    Professor of Genetics

    Dr Luke Gaughan
    Senior Lecturer