Publication:

Muscular dystrophies and the dystrophin-glycoprotein complex (1997)

Author(s): V. Straub;K. P. Campbell

  • : Muscular dystrophies and the dystrophin-glycoprotein complex

Abstract: Efforts to understand the function of dystrophin, the protein product for the Duchenne muscular dystrophy gene, resulted in the purification of the dystrophin-glycoprotein complex. Over the past year several novel components of this complex have been identified. Recent studies have extended the number of muscular dystrophies associated with the oligomeric complex to six genetically distinct diseases, including three new forms of limb-girdle muscular dystrophy and one form of congenital muscular dystrophy.

  • Short Title: Muscular dystrophies and the dystrophin-glycoprotein complex
  • Date: Apr
  • Journal: Curr Opin Neurol
  • Volume: 10
  • Issue: 2
  • Pages: 168-75
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Animals Child Dystrophin/ genetics/physiology Gene Expression/physiology Genotype Humans Membrane Glycoproteins/ genetics/physiology Mice Mice, Transgenic Muscular Dystrophies/classification/ genetics/physiopathology Phenotype

Staff

Professor Volker Straub
Harold Macmillan Professor of Medicine