Publication:

Does metergoline selectively attenuate 5-HT mediated prolactin release? (1991)

Author(s): Ellis PM, Gartside SE, Ware CJ, Campling GM, Cowen PJ

  • : Does metergoline selectively attenuate 5-HT mediated prolactin release?

Abstract: Administration of the non-selective 5-HT receptor antagonist metergoline (0.5 mg/kg) to male rats attenuated the prolactin response to the 5-HT releasing agent d-fenfluramine (7.5 mg/kg) but not to the dopamine receptor antagonist haloperidol (1.5 mg/kg). In contrast, in healthy male volunteers, pretreatment with metergoline (4 mg orally) abolished the prolactin response to intravenous haloperidol (5 micrograms/kg). The findings suggest that in humans blockade of a prolactin response by a conventional oral dose of metergoline cannot be taken as evidence of involvement of 5-HT-mediated mechanisms.

Notes: 0033-3158 (Print) Journal Article

  • Type of Article: Original investigation
  • Short Title: Does metergoline selectively attenuate 5-HT mediated prolactin release?
  • Date: March 1991
  • Journal: Psychopharmacology (Berl)
  • Volume: 105
  • Issue: 1
  • Pages: 129-131
  • Publisher: Springer
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Adolescent Adult Animals Brain Chemistry/drug effects Fenfluramine/pharmacology Haloperidol/pharmacology Humans Male Metergoline/*pharmacology Prolactin/*metabolism Rats Rats, Inbred Strains Research Support, Non-U.S. Gov't Serotonin/pharmacology Serotonin Antagonists/*pharmacology

Staff

Dr Sasha Gartside
Senior Lecturer