Publication:

The role of antigen-presenting cells in the regulation of allergen-specific T cell responses (1998)

Author(s): Kapsenberg ML, Hilkens CM, Wierenga EA, Kalinski P

  • : The role of antigen-presenting cells in the regulation of allergen-specific T cell responses

Abstract: Allergic reactions in atopic patients follow from a generalized enhanced polarization of Th cells, predominantly imposed by factors derived from antigen-presenting cells from a pathogen-stressed tissue; these sample information not only on antigen structures but also on the nature of the stress. Antigen-presenting cells of atopic individuals show aberrant characteristics which, through a highly interactive communication network, play an active role in aberrant Th-cell polarization. This generalized bias may follow from intrinsic abnormalities of antigen-presenting cells and also from a low degree of cross-regulation by micro-organisms.

Notes: 0952-7915 Journal Article Review Review, Tutorial

  • Short Title: The role of antigen-presenting cells in the regulation of allergen-specific T cell responses
  • Date: December 1998
  • Journal: Current Opinion in Immunology
  • Volume: 10
  • Issue: 6
  • Pages: 607-613
  • Publisher: Elsevier
  • Publication type: Article
  • Bibliographic status: Published

Keywords: Allergens/*immunology Animals Antigen-Presenting Cells/*immunology Dogs Human Interleukin-12/immunology Mycobacterium Infections/immunology T-Lymphocytes/*immunology T-Lymphocytes, Helper-Inducer/immunology

Staff

Dr Catharien Hilkens
Reader in Immunotherapy