Cyclophosphamide metabolism in children following a 1-h and a 24-h infusion (2001)

Author(s): Yule SM, Price L, Cole M, Pearson ADJ, Boddy AV

    Abstract: Purpose: The pharmacokinetics and metabolism of cyclophosphamide (CPA) when given as a 1-h and a 24-h infusion to children were compared. Methods: Thirteen children with a variety of different malignancies received an identical dose of cyclophosphamide as a 1- and 24-h infusion. In each case the concentration of CPA and its principal metabolites were measured by a thin-layer-chromatography-photographic-densitometry technique. Results: Cyclophosphamide clearance was greater during the 24-h infusion, following time-dependent increases in the metabolism of the drug (autoinduction) (median 5.1 vs 3.1 l/h/m2: P=0.037). Autoinduction was seen in five children (38%), producing a median end of infusion concentration of 49% (range 28-89%) of the maximum and was not accompanied by an increase in the production of the principal inactive metabolites carboxyphosphamide and dechloroethylcyclophosphamide. Conclusions: These results suggest potential benefits of prolonging the infusion of CPA in clinical practice.

      • Date: 01-03-2001
      • Journal: Cancer Chemotherapy and Pharmacology
      • Volume: 47
      • Issue: 3
      • Pages: 222-228
      • Publication type: Article
      • Bibliographic status: Published

      Professor Alan Boddy
      Professor of Cancer Pharmacology