Publication:

Immunogenetics in PSC (2001)

Author(s): Donaldson PT; Norris S

    Abstract: Primary sclerosing cholangitis (previous termPSC)next term does not exhibit simple Mendelian inheritance attributable to a single gene locus and our knowledge of the genetics of this complex disease is based entirely on case-control studies of candidate genes. The prime candidates in previous termPSCnext term are inherited variation (polymorphism) in the genes that regulate the immune response, especially the genes of the major histocompatability complex (MHC). Thus far, five different human leukocyte antigen (HLA) haplotypes have been associated with previous termPSC:next term three with increased risk of disease and two with reduced risk. More recently studies of non-MHC genes have failed to associate previous termPSCnext term with several cytokine genes (IL-1 and IL-10), with FAS (TNFRSF6), with TGFβ-1, or with CCR-5 but have found genetic links with MMP-3 and disease progression, whilst the potential role of CTLA-4 gene polymorphism remains in question.With the completion of the human genome project, understanding the genetics of complex (non-Mendelian) disease is a major priority for the research community and the studies summarized herein may guide these future investigations.

      • Date: 12-03-2002
      • Journal: Best Practice & Research Clinical Gastroenterology
      • Volume: 15
      • Issue: 4
      • Pages: 611-627
      • Publisher: Bailliere Tindall
      • Publication type: Article
      • Bibliographic status: Published
      Staff

      Dr Peter Donaldson
      Senior Lecturer