NIHR Newcastle Biomedical Research Centre in Ageing & Chronic Disease
The Ageing Brain: Dementia & Stroke
Cognitive decline and dementia are growing and global problems, with few therapeutic options apart from modest symptomatic treatments for Alzheimer’s disease. Vascular dementia (including dementia after stroke and subcortical vascular dementia), a key area of interest within the theme, is the second commonest cause of dementia.
The main research strands within the Ageing Brain theme are to investigate key mechanisms and substrates underpinning cognitive decline and brain ageing, with the aim of identifying new targets to assist with early diagnosis, including identification of those 'at risk', and for novel therapeutic intervention.
Through a combination of longitudinal clinical studies and studies on tissue from the Newcastle Brain Tissue Resource, we are identifying important cognitive, clinical and brain imaging changes associated with different brain pathologies and investigating both pharmacological and non-pharmacological therapeutic approaches.
- Theme Lead – Professor Ian McKeith
- Dr Johannes Attems
- Professor Raj Kalaria
- Professor Lynn Rochester
- Professor Andy Blamire
- Dr John-Paul Taylor
- Dr Alan Thomas
