The Wellcome Trust Centre for Mitochondrial Research

Mitochondrial DNA is present in all human cells and correct expression of the mitochondrial
genome is essential for life. Every cell in the body requires energy to function. This energy is provided by mitochondria, often referred to as the cells' 'powerhouses'. When these 'powerhouses' fail then the patients develop mitochondrial disease with symptoms often involving tissues that are heavily dependent on energy such as the heart, muscles and brain.

Mitochondrial genetic defects cause multisystem disease and have been linked to common degenerative disorders such as Parkinsons disease, suggesting that the impact of energy failure might be greater than expected and an important cause of ageing and degenerative disease. Understanding this link may help prevent these diseases developing in the future.

The Wellcome Trust Centre for Mitochondrial Research was established in May 2012 to integrate basic and clinical mitochondrial disease research, train exceptional young researchers and undertake public and policy engagement. It is funded to address four specific research themes:

  • Identify critical factors and pathogenic defects underlying mitochondrial gene expression
  • Prevent transmission of mitochondrial DNA disease
  • Understand the nature, mechanisms and treatment of neurology deficits in patients with mitochondrial DNA disease
  • Determine the role of mitochondrial DNA in common chronic human diseases

We have very close links to the NHS Highly Specialised NHS Service for Rare Mitochondrial Disorders of Adults and Children. This clinical service based in Newcastle provides care for patients throughout the UK both in terms of diagnosis and management.

In addition, the next generation of scientists is being developed through a new training program in mitochondrial medicine for outstanding young researchers. We have established a new MRes course in Mitochondrial Biology and Medicine and developed a network of PhD and post-doctoral training schemes.

We are developing new ways of explaining our research to both our patients and the general public. Our work to prevent the disease passing from mothers to children involves new IVF techniques that involve a greater understanding by the public as well as discussion with key policy makers. We will develop new approaches to engage with patients and public, and guide policy development to support the use of new techniques to prevent transmission of mitochondrial DNA disease.

Contact

Professor Doug Turnbull
Director of Centre and Professor of Neurology
doug.turnbull@ncl.ac.uk
Website: Wellcome Trust Centre for Mitochondrial Research

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