Newcastle University

Pharmacology, Therapeutics and Toxicology Research Group

Research Achievements

This research group is comprised of individuals who have interacted informally and collaborated on research projects involving a range of aspects of Toxicology and Pharmacology. All members have pursued interests in the toxicity and adverse effects of chemicals and drugs. Recently group members have obtained significant research funding and published research in high impact journals.

Current research income European Community, Department for Environment, Food and Rural Affairs, British Heart Foundation , Commission for Rural Communities, Department of Health. Current research includes toxicity and anticoagulant therapy (Kamali, Daly) toxicology of chronic exposure to pesticides (organophosphates) (Williams, Mutch, Blain), psychiatric drugs and cardiotoxicity (Thomas), adverse fetal effects of drug treatment (Thomas, McElhatton), hepatotoxicity (Daly and Wright) adverse effects of anticancer drugs (Boddy).

Research Strategy

We bring together research teams in the Faculty with overlapping interests in the areas of Toxicology and Pharmacology who have previously interacted informally. We will use this collaboration as a basis to develop new research projects and grant applications which will generate joint publications. We will relate the clinical features and human biomarkers of drug and chemical induced toxicity to in vitro mechanistic studies using human derived cell lines and human tissues. We will investigate factors contributing to functional susceptibility and vulnerability to drugs such as age, drug interactions, environmental chemical exposure. The interests of this group will complement those of the Pharmacogenomics and Complex Diseases Group to which several members also belong.

Further information about this area of research can be found on the websites for the Medical Toxicology Centre, Institute for Research on Environment and Sustainability, and ICM.

Staff List

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