Prof. Ann Daly
Professor of Pharmacogenetics
- Email: A.K.Daly@ncl.ac.uk
- Telephone: +44 (0) 191 222 7031
- Address: Institute of Cellular Medicine
The Medical School
Newcastle University
Newcastle upon Tyne
NE2 4HH
Research Interests
Pharmacogenetic studies on the discovery of novel human genetic polymorphisms, their functional significance and their relationship to outcome of drug therapy, susceptibility to adverse drug reactions and susceptibility to complex diseases such as liver disease, cancer and hypertension.
Selected Publications
- Daly AK; Donaldson PT; Bhatnagar P; Shen Y; Peer I; Floratos A; Daly MJ; Goldstein DB; John S; Nelson MR; Graham J; Park BK; Dillon JF; Bernal W; Cordell HJ; Pirmohamed M; Aithal GP; Day CP. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nature Genetics 2009, 41, 816-819.
- Klein TE; Altman RB; Eriksson N; Gage BF; Kimmel SE; Lee MTM; Limdi NA; Page D; Roden DM; Wagner MJ; Caldwell MD; Johnson JA; Chen YT; Wen MS; Caraco Y; Achache I; Blotnick S; Muszkat M; Shin JG; Kim HS; Suarez-Kurtz G; Perini JA; Silva-Assuncao E; Anderson JL; Horne BD; Carlquist JF; Caldwell MD; Berg RL; Burmester JK; Goh BC; Lee SC; Kamali F; Sconce E; Daly AK; Wu AHB; Langaee TY; Feng H; Cavallari L; Momary K; Pirmohamed M; Jorgensen A; Toh CH; Williamson P; McLeod H; Evans JP; Weck KE; Brensinger C; Nakamura Y; Mushiroda T; Veenstra D; Meckley L; Rieder MJ; Rettie AE; Wadelius M; Melhus H; Stein CM; Schwartz U; Kurnik D; Deych E; Lenzini P; Eby C; Chen LY; Deloukas P; Motsinger-Reif A; Sagreiya H; Srinivasan BS; Lantz E; Chang T; Ritchie M; Lu LS; Shin JG; Int Warfarin Pharmacogenetics Cons. Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data. New England Journal of Medicine 2009, 360(8), 753-764.
- Andrews EAG; Daly AK. Flucloxacillin-induced liver injury. Toxicology 2008, 254(3), 158-163.
- Daly, A.K, Aithal, G.P, Leathart, J.B.S, Swainsbury, R.A, Dang, T.S, Day, C.P. Genetic Susceptibility to Diclofenac-Induced Hepatotoxicity: Contribution of UGT2B7, CYP2C8 and ABCC2 Genotypes. Gastroenterology 2007, 132(1), 272-281.
- Thanacoody RH, Daly AK, Reilly JG, Ferrier IN, Thomas SH. Factors Affecting Drug Concentrations and QT Interval During Thioridazine Therapy. Clinical Pharmacology and Therapeutics 2007, 82(5), 555-565.
- Daly AK. Individualized drug therapy. Current opinion in Drug Discovery and Development 2007, 10, 29-36.
Qualifications
BA in Biochemistry (University of Dublin);
PhD in Biochemistry (University of Dublin).
Undergraduate Teaching
Module leader for PED2001 Drug disposition and Pharmacogenetics and PED3005 Advanced Pharmacogenetics.
