studies on the discovery of novel human genetic polymorphisms, their functional
significance and their relationship to outcome of drug therapy, susceptibility
to adverse drug reactions and susceptibility to complex diseases. These studies are central to the area of personalised (stratified) medicine and
a key aim is to translate our findings to simple tests that can be used to determine the most appropriate drug treatment on an individual basis.
I coordinate the iDILIC network on genetics of drug-induced liver injury ( http://www.ncl.ac.uk/icm/research/project/4568) and see also (http://www.ncl.ac.uk/numed/about/news/item/newcastle-university-leading-project-on-drug-induced-liver-disease-copy) together with the UK DILIGEN project (www.diligen.org).
I am an organiser of the 2014 Cold Spring Harbor conference on Personal Genomes: Discovery, Treatment and Outcomes ( https://meetings.cshl.edu/meetings/2014/pgmg14.shtml ).