Newcastle University

Roles and Responsibilities

Head Tyneside Leukaemia Research Laboratories
Co-director Stem Cell Manipulation and Cryopreservation Unit, Department Haematology

Research Interests

Haematopoietic stem cell transplant immunobiology.
Graft versus host disease immunobiology and immunomodulation.
Non-HLA immunogenetics and relevance to transplant outcome.
Cord blood transplantation and human haematopoietic stem cell differentiation.
Translational research; clinical application of research results.

Funding

Commission of the European Communities
Tyneside Leukaemia Research Association
Leukaemia Research Association
Marie Curie training Fellowship

• Pearce KF, Lee SJ, Haagenson M, Petersdorf EF, Norden J, Collin MP, Klein JP, Spellman SR, Lowerson SA, Davies S, Dickinson AM. Analysis of non- HLA genomic risk factors in HLA-matched unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia. Haematologica 2012, (epub ahead of print).
• Stocki P, Wang XN, Dickinson AM. Inducible Heat Shock Protein 70 Reduces T cell Responses and Stimulatory Capacity of Monocyte-derived Dendritic Cells. Journal of Biological Chemistry 2012, 287(15), 12387-12394.
• Wang X, Turner B, O'Boyle G, Douglass S, Ahmed S, Mavin E, Collin M, Ali S, Dickinson AM. Blocking effector T-cell trafficking contributes to regulatory T-cell mediated suppression of GvHD reactions. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
• Atarod S, Norden J, Kuzyk-Czucha A, Bogunia-Kubik K, Turner B, Ambler L, Wang XN, Collin M, Dickinson AM. Correlation of HSPA1Lexpression with the development of graft-versus-host disease. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
• Pearce KF, Norden J, Collin M, Hromadnikova I, Sedlacek P, Cornelissen JJ, Wolff D, Aubano A, Holtick U, Scheid C, Socie G, Greinix H, Holler E, Dickinson AM. Development of an algorithm to predict acute GvHD and chronic GvHD in HLA-matched sibling, non-T cell depleted haematopoietic stem cell transplants. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
• Novota P, Zinocker S, Norden J, Wang XN, Sviland L, Opitz L, Salinas-Riester G, Rolstad B, Dickinson AM, Walter L, Dressel R. Expression profiling of major histocompatibility and natural killer complex genes reveals new candidates for controlling risk of graft versus host disease. In: Tissue Antigens: 25th Conference on European Immunogenetics and Histocompatibility. 2011, Prague, Czech Republic: Wiley-Blackwell Publishing, Inc.
• Stocki P, Wang XN, Morris NJ, Dickinson AM. HSP70 Natively and Specifically Associates with an N-terminal Dermcidin-derived Peptide That Contains an HLA-A*03 Antigenic Epitope. Journal of Biological Chemistry 2011, 286(14), 12803-12811.
• Ahmed S, Norton J, Nong XW, Turner B, El-gezawy E, Collins M, Hromadnikova I, Sedlacek P, Dickinson AM. Increased expression of the chemokines CXCL10 and CXCL11 are associated with the development of graft-versus-host disease. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
• Shamim Z, Ryder LP, Christensen IJ, Toubert A, Norden J, Collin M, Jackson G, Dickinson AM, Muller K. Prognostic Significance of Interleukin-7 Receptor-alpha Gene Polymorphisms in Allogeneic Stem-Cell Transplantation: A Confirmatory Study. Transplantation 2011, 91(7), 731-736.
• Weissinger EM, Wolff D, Metzger J, Dobbelstein CE, Buchholz S, Dammann E, Borchert U, Krons A, Diedrich H, Stadler M, Dickinson AM, Holler E, Greinix HT, Krauter J, Ganser A. Prospective Validation of a Chronic GvHD-Specific Proteome Pattern (cGvHD-MS14) Post Allogeneic Hematopoietic Stem Cell Transplantation. In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.
• Mavin ER, Dickinson AM, Wang XN. Regulatory T cell suppressive functions are not affected by cryo-preservation. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Ruffin N, Ahmed SS, Osorio LM, Wang XN, Jackson GH, Collin MP, Ekre HP, Chiodi F, Dickinson AM. The Involvement of Epithelial Fas in a Human Model of Graft Versus Host Disease. Transplantation 2011, 91(9), 946-951.
• Weissinger EM, Metzger J, Dobbelstein C, Dammann E, Holler E, Dickinson AM, Greinix H, Konig J, Borchert U, Krons A, Hahn N, Diedrich H, Stadler M, Krauter J, Ganser A. Validation of a chronic GvHD-specific proteome pattern post-allogeneic haematopoietic stem cell transplantation. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
• Qudaihi G, Lehe C, Dickinson A, Eltayeb K, Rasheed W, Chaudhri N, Aljurf M, Dermime S. Identification of a novel peptide derived from the M-phase phosphoprotein 11 (MPP11) leukemic antigen recognized by human CD8+ cytotoxic T lymphocytes. Hematology - Oncology and Stem Cell Therapy 2010, 3(1), 24-33.
• Kuzyk A, Bogunta-Kubik K, Jackson G, Cullin M, Wang XN, Dickinson A. HSP70-hom gene polymorphism as a risk factor of graft-versus-host disease. In: 2nd European Congress of Immunology (ECI). 2009, Berlin, Germany: Medimond SRL.
• Dickinson AM, Wang X-N, Stark G, Cullup H, Jarvis M, Middleton PG. Beyond HLA-typing: Genetic polymorphisms predicting transplant outcome. In: Apperley, J.F., Gluckman, E., Gratwohl, A, ed. The EBMT Handbook - Blood and Marrow Transplantation. Paris, France: European School of Haematology, 2004.
• Cullup H, Middleton PG, Duggan G, Conn JS, Dickinson AM. Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals. Clinical and Experimental Immunology 2004,137 2 351-358.
• Dickinson AM, Middleton PG, Rocha V, Gluckman E, Holler E. Genetic polymorphisms predicting the outcome of bone marrow transplants. British Journal of Haematology 2004. ,127 5 479-490.
• Collin M, Munster D, Clark G, Wang XN, Dickinson A, Hart D. Antibody-mediated suppression of allogeneic responses by targeting the tissue dendritic cell: A potential role for CMRF-44 where alemtuzumab fails. In: Blood: 45th Annual Meeting of the American Society of Hematology. 2003, San Diego, California, USA: American Society of Hematology.
• Middleton PG, Dickinson AM, Jarvis M, Cavet J, Cullup H, Jackson GH. Clinical and genotypic risk factors for GvHD are modulated by prophylaxis: A multicentre cohort study of HLA matched sib-allo BMT. In: Genes and Immunity: 17th European Histocompatability Conference. 2003, Baden, Germany: Nature Publishing Group.
• Dickinson AM, Stark G, Cullup H, Jarvis M, Wang XN, Middleton PG. Cytokine Gene Polymorphism in Transplantation. Hematopoietic Stem Cells Research and Clinical Applications 2003, European School of Haematology.
• Jarvis M, Marzolini M, Wang XN, Jackson G, Sviland L, Dickinson AM. Heat shock protein 70: Correlation of expression with degree of graft-versus-host response and clinical graft-versus-host disease. Transplantation 2003, 76(5), 849-853.
• Jarvis M, Marzolini MAV, Wang XN, Sviland L, Dickinson AM. Heat shock protein 70: Correlation of expression with degree of graft-versus-host response and clinical GVHD: Quantitative assessment using laser scanning confocal microscopy. In: Genes and Immunity: 17th European Histocompatability Conference. 2003, Baden, Germany: Nature Publishing Group.
• Cullup H, Wang XN, Dickinson AM. HLA-matcing influences the production of the IL-1 family of cytokines in an alloimmune response. In: Genes and Immunity: 17th European Histocompatability Conference. 2003, Baden, Germany: Nature Publishing Group.
• Mainou-Fowler T, Taylor PRA, Miller S, Dickinson AM, Proctor SJ. Intracellular cytokine profiles by peripheral blood CD3(+) T-cells in patients with classical Hodgkin lymphoma. Leukemia and Lymphoma 2003, 44(8), 1325-1331.
• Dickinson AM, Wang XN, Sviland L, Cullup H. Neutralisation of IL-1 receptor antagonist is associated with increased graft versus host damage demonstrated in a human in vitro modified model of graft versus host disease. In: Blood: 45th Annual Meeting of the American Society of Hematology. 2003, San Diego, California, USA: American Society of Hematology.
• Barrett AJ, Rezvani K, Soloman S, Dickinson AM, Wang X-N, Stark G, Cullup H, Jarvis M, Chao N. New Developments in allotransplant immunology. In: American Society of Hematology Education Program. Bethesda, Maryland, USA: America Society of Hematology, 2003, pp.350-371.
• Middleton PG, Norden J, Cullup H, Cavet J, Jackson GH, Taylor PRA, Dickinson AM. Oestrogen receptor α gene polymorphism associates with occurrence of graft-versus-host disease and reduced survival in HLA-matched sib-allo BMT. Bone Marrow Transplantation 2003, 32(1), 41-47.
• Cullup H, Dickinson AM, Cavet J, Jackson GH, Middleton PG. Polymorphisms of interleukin-1α constitute independent risk factors for chronic graft-versus-host disease after allogeneic bone marrow transplantation. British Journal of Haematology 2003,122 5 778-787.
• Cullup H, Wang XN, Dickinson AM. The level of IL-1B and IL-1RA in MLR supernatants is associated with the incidence of aGVHD following HLA-matched sibling BMT. In: Genes and Immunity: 17th European Histocompatability Conference. 2003, Baden, Germany: Nature Publishing Group.
• Stark, G. L., Dickinson, A. M., Jackson, G. H., Taylor, P. R. A., Proctor, S. J., Middleton, P. G. Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation. Transplantation 2003, 76(12), 1742-1749.
• Dickinson AM. HLA immunogenetics in haematopoietic stem cell transplantation. Blood 2002, 100(12), 3851-3852.
• Dickinson AM, Wang XN, Sviland L, Vyth-Dreese FA, Jackson GH, Schumacher TNM, Haanen JBAG, Mutis T, Goulmy E. In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens. Nature Medicine 2002, 8(4), 410-414.
• Stechova K, Vavrincova P, Chudoba D, Frantlova M, Reitzova H, Sosna A, Zimak J, Lednicky L, Dickinson AM, Hromadnikova I. In vitro autoreactivity against skin and synovial cells in patients with juvenile idiopathic and rheumatoid arthritis. Pathobiology 2002, 70(2), 76-82.
• Wang XN, Lange C, Schulz U, Sviland L, Eissner G, Oliver KM, Jackson GH, Holler E, Dickinson AM. Interleukin-10 modulation of alloreactivity and graft-versus-host reactions. Transplantation 2002, 74(6), 772-778.
• Dickinson AM, Cavet J, Cullup H, Wang XN, Jarvis M, Sviland L, Middleton PG. Predicting outcome in hematological stem cell transplantation. Archivum Immunologiae et Therapiae Experimentalis 2002. ,50 6 371-378.
• Jarvis M, Schulz U, Dickinson AM, Sviland L, Jackson G, Konur A, Wang XN, Hromadnikova I, Kolb HJ, Eissner G, Holler E. The detection of apoptosis in a human in vitro skin explant assay for graft versus host reactions. Journal of Clinical Pathology 2002, 55(2), 127-132.
• Hromadnikova I, Sedlacek P, Stary J, Cermakova M, Vavrinec J, Stechova K, Dolezalova L, Sviland L, Dickinson AM. An in vitro skin explant assay as a predictive assay for graft-versus-host disease in a cohort of pediatric transplants. Pediatric Transplantation 2001, 5(4), 258-265.
• Gennery AR, Dickinson AM, Brigham K, Barge D, Spickett GP, Curtis A, Spencer V, Jackson A, Carter V, Palmer P, Flood TJ, Cant AJ, Abinun M. CAMPATH-1M T-cell depleted BMT for SCID: long-term follow-up of 19 children treated 1987-98 in a single center. Cytotherapy 2001, 3(3), 221-232.
• Gennery AR, Dickinson AM, Brigham K, Barge D, Spickett GP, Curtis A, Spencer V, Jackson A, Cavanagh G, Carter V, Palmer P, Flood TJ, Cant AJ, Abinun M. CAMPATH-1M T-cell depleted BMT for SCID: Long-term follow-up of 19 children treated 1987-98 in a single center. Cytotherapy 2001, 3(3), 221-232.
• Cullup H, Dickinson AM, Jackson GH, Taylor PR, Cavet J, Middleton PG. Donor interleukin 1 receptor antagonist genotype associated with acute graft-versus-host disease in human leucocyte antigen-matched sibling allogeneic transplants. British Journal of Haematology 2001, 113(3), 807-813.
• Mainou-Fowler T, Proctor SJ, Miller S, Dickinson AM. Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia. Leukemia and Lymphoma 2001, 42(4), 689-698.
• Mainou-Fowler T, Proctor SJ, Dickinson AM. Gamma linolenic acid induces apoptosis in B-chronic lymphocytic leukaemia cells in vitro. Leukemia and Lymphoma 2001, 40(3-4), 393-403.
• Sviland L, Hromadnikova I, Sedlacek P, Cermakova M, Stechova K, Holler E, Eissner G, Schulz U, Kolb HJ, Jackson G, Wang XN, Dickinson AM. Histological correlation between different centers using the skin explant model to predict graft-versus-host disease following bone marrow transplantation. Human Immunology 2001, 62(11), 1277-1281.
• Cavet J, Dickinson AM, Norden J, Taylor PRA, Jackson GH, Middleton PG. Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood 2001, 98(5), 1594-1600.
• Wang XN, Dickinson AM, Sviland L, Vyth-Dreese FA, Jackson GH, Schumacher TNM, Haanen JBAG, Mutis T, Goulmy E. Minor histocompatibility antigen specific CTLs and in situ skin graft versus host reactions. In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2001, Orlando, Florida, USA: American Society of Hematology.
• Hromadníková I, Sedlácek P, Starý J, Vavrinek J, Cermáková M, Stechova K, Houbova B, Vitek A, Sajdova J, Sviland L, Dickinson AM. Skin explant assay - an in vitro graft versus host disease predictive test for allogeneic haematopoietic stem cell transplant. Journal of Czech Physicians 2001, 140, 73-78.
• Mainou-Fowler T, Miller S, Proctor SJ, Dickinson AM. The levels of TNFα, IL4 and IL10 production by T-cells in B-cell chronic lymphocytic leukaemia (B-CLL). Leukemia Research 2001, 25(2), 157-163.
• Dickinson AM, Cullup H, Cavet J, Middleton PG. Cytokines and Chemokines. Immunobiology of Transplantation: From Basic Science to Practical Medicine 2000, European School of Haematology (Euroconference II).
• Adams I, Taylor PRA, Jackson GH, Angus B, Watson P, Mounter P, McKay P, Dickinson AM, Oliver K, Jack F. Development of a novel prognostic score for mantle cell lymphoma. In: BLOOD. 2000.
• Cullup H, Dickinson AM, Jackson GH, Taylor PR, Cavet J, Middleton PG. Donor interleukin-1 receptor antagonist genotype associated with acute graft versus host disease in HLA-matched sibling allogeneic transplants. In: BLOOD. 2000.
• Dickinson AM, Wang XN, Sviland L. In vitro models of graft-versus-host disease. In: Cohen SBA; Gluckman E; Rubinstein P; Madrigal JA, ed. Cord Blood Characteristics: Role in stem cell transplantation. London: Martin Dunitz, 2000, pp.97-127.
• Wang XN, Taylor PRA, Skinner R, Jackson GH, Proctor SJ, Hedley D, Dickinson AM. T-cell frequency analysis does not predict the incidence of graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Transplantation 2000, 70(3), 488-493.
• Holler E, Schulz U, Jarvis M, Dickinson AM, Sviland L, Hromadnikova I, Jackson G, Konur A, Eissner G, Andreesen R. The detection of keratinocyte apoptosis in a human skin explant assays for prediction of graft-versus-host disease. In: BLOOD. 2000.
• Mainou-Fowler T, Dickinson AM, Taylor PRA, Mounter P, Jack F, Proctor SJ, Norden J, Middleton PG. Tumour necrosis factor gene polymorphisms in lymphoproliferative disease. Leukemia and Lymphoma 2000, 38(5-6), 547-552.
• Cavet J, Dickinson AM, Norden J, Jackson GH, Taylor PRA, Middleton PG. Vitamin D receptor gene polymorphism associates with acute graft versus host disease and survival in HLA-matched sibling allogeneic bone marrow transplantation. In: BLOOD. 2000.
• Sviland L, Dickinson AM. A human skin explant model for predicting graft-versus-host disease following bone marrow transplantation. Journal of Clinical Pathology 1999, 52(12), 910-913.