Research Groups - Newcastle Biomedicine

Professor David Jones
Dean of Translational Research

Email: david.jones@ncl.ac.uk
Telephone: +44 (0) 191 222 8696
Personal Website: http://www.ncl.ac.uk/biomedicine/research/groups/liver.htm
Address: Clinical Academic Office
3rd Floor, William Leech Building
Faculty of Medical Sciences
Newcastle University
Newcastle upon Tyne
NE2 4HH

Publications

Stewart SF, Vidali M, Day CP, Albano E, Jones DEJ. Oxidative Stress as a Trigger for Cellular Immune Responses in Patients with Alcoholic Liver Disease. Hepatology 2004, 39(1), 197-203.
Palmer JM, Robe AJ, Burt AD, Kirby JA, Jones DEJ. Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse. Hepatology 2004, 39(6), 1583-1592.
Jones DEJ, Palmer JM, Burt AD, Walker C, Robe AJ, Kirby JA. Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complex. Hepatology 2002, 36(3), 679-686.
Goldblatt J, Taylor PJS, Lipman T, Prince MI, Baragiotta A, Bassendine MF, James OFW, Jones DEJ. The true impact of fatigue in primary biliary cirrhosis: A population study. Gastroenterology 2002, 122(5), 1235-1241.
Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D. Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. Hepatology 2006, 44(1), 91-98.
Hollingsworth KG, Jones DE, Aribisala BS, Thelwall PE, Taylor R, Newton JL, Blamire AM. Globus pallidus magnetisation transfer ratio, T1 and T2 in primary biliary cirrhosis: relationship with disease stage and age. Journal of Magnetic Resonance Imaging 2009, 29(4), 780-784.
Hollingsworth KG, Newton JL, Taylor R, McDonald C, Palmer JM, Blamire AM, Jones DEJ. Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis. Clinical Gastroenterology and Hepatology 2008, 6(9), 1041-1048.
Newton JL, Pairman J, Sutcliffe K, Wilton K, Jones DEJ. A Predictive Model for Fatigue and Its Etiologic Associations in Primary Biliary Cirrhosis. Clinical Gastroenterology and Hepatology 2008, 6(2), 228-233.
Newton JL, Hollingsworth KG, Taylor R, El-Sharkawy AM, Khan ZU, Pearce R, Sutcliffe K, Okonkwo O, Davidson A, Burt J, Blamire AM, Jones DEJ. Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential etiology. Hepatology 2008, 48(2), 541-549.
Rygiel KA, Robertson H, Marshall HL, Pekalski M, Zhao L, Booth TA, Jones DEJ, Burt AD, Kirby JA. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Laboratory Investigation 2008, 88(2), 112-123.
Newton JL, Jones DEJ, Henderson E, Kane L, Wilton K, Burt AD, Day CP. Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. Gut 2008, 57(6), 807-813.
Walden HR, Kirby JA, Yeaman SJ, Gray J, Jones DE, Palmer JM. Xenobiotic Incorporation into Pyruvate Dehydrogenase Complex Can Occur Via the Exogenous Lipoylation Pathway. Hepatology 2008, 48(6), 1874-1884.
Jones DEJ, Newton JL. An open study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis. Alimentary Pharmacology and Therapeutics 2007, 25(4), 471-476.
Newton JL, Davidson A, Kerr S, Bhala N, Pairman J, Burt J, Jones DEJ. Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity. European Journal of Gastroenterology and Hepatology 2007, 19(2), 125-132.
Robertson H, Kirby JA, Yip WW, Jones DEJ, Burt AD. Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis. Hepatology 2007, 45(4), 977-981.
Jones DEJ. Complications of cholestasis. Medicine 2007, 35(2), 96-98.
Donaldson P, Veeramani S, Baragiotta A, Floreani A, Venturi C, Pearce S, Wilson V, Jones D, James O, Taylor J, Newton J, Bassendine M. Cytotoxic T-Lymphocyte-Associated Antigen-4 Single Nucleotide Polymorphisms and Haplotypes in Primary Biliary Cirrhosis. Clinical Gastroenterology and Hepatology 2007, 5(6), 755-760.
Jones DEJ. Fatigue in cholestatic liver disease: Is it all in the mind?. Journal of Hepatology 2007, 46(6), 992-994.
Jones DEJ, Newton JL. Fatigue-associated mortality in Primary Biliary Cirrosis is principally a problem of the over 65’s. Gut 2007, 56, 1166.
Newton JL, Hudson M, Tachtatzis P, Sutcliffe K, Pairman J, Burt JA, Jones DEJ. Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis. Hepatology 2007, 45(6), 1496-1505.
Blackburn P, Freeston M, Baker CR, Jones DEJ, Newton JL. The role of psychological factors in the fatigue of primary biliary cirrhosis. Liver International 2007, 27(5), 654-661.
Broad A, Kirby JA, Jones DEJ. Toll-like receptor interactions: Tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-β production. Immunology 2006, 120(1), 103-111.
Linnett VC, Jones DEJ. Anaesthesia for patients with chronic liver disease. CPD Anaesthesia 2006, 8(2), 87-94.
Newton JL, Jones DEJ, Wilton K, Pairman J, Parry SW, Francis RM. Calcaneal bone mineral density in older patients who have fallen. QJM: An International Journal of Medicine 2006, 99(4), 231-236.
Newton JL, Bhala N, Burt J, Jones DEJ. Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure. Journal of Hepatology 2006, 44(4), 776-783.
McHugh A, Robe AJ, Palmer JM, Jones DEJ. PDC-E3BP is not a dominant T-cell autoantigen in primary biliary cirrhosis. Liver International 2006, 26(4), 406-413.
Jones DEJ, Bhala N, Burt J, Goldblatt J, Prince M, Newton JL. Four year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort. Gut 2006, 55(4), 536-541.
Donaldson PT, Baragiotta A, Heneghan MA, Floreani A, Venturi C, Underhill JA, Jones DEJ, James OFW, Bassendine MF. HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: A large-scale study. Hepatology 2006, 44(3), 667-674.
Jones DEJ, Newton JL. Primary biliary cirrhosis. Horizons in Medicine 2006, 17, 307-315.
Newton JL, Allen J, Kerr S, Jones DEJ. Reduced heart rate variability and baroreflex sensitivity in primary biliary cirrhosis. Liver International 2006, 26(2), 197-202.
Jones DEJ, Bhala N, Newton JL. Reflections on therapeutic trials in primary biliary cirrhosis: A qualify of life oriented counter-view. Hepatology 2006, 43(3), 633.
Broad A, Jones DEJ, Kirby JA. Toll-like receptor (TLR) response tolerance: A key physiological "damage limitation" Effect and an important potential opportunity for therapy. Current Medicinal Chemistry 2006, 13(21), 2487-2502.
Robe AJ, Kirby JA, Jones DEJ, Palmer JM. A key role for autoreactive B cells in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex in the mouse. Hepatology 2005, 41(5), 1106-1112.
Baragiotta A, Floreani A, Agarwal K, Venturi C, Craggs A, Jones DEJ, Donaldson PT, Bassendine MF. Chemokine receptor 5 and primary biliary cirrhosis: A two-centre genetic association study. Liver International 2004, 24(6), 646-650.
Jacoby A, Rannard A, Buck D, Bhala N, Newton JL, James OFW, Jones DEJ. Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis. Gut 2005, 54(11), 1622-1629.
Rannard AC, Buck D, Jacoby A, James OFW, Jones DEJ. Assessing quality of life in primary biliary cirrhosis. Clinical Gastroenterology and Hepatology 2004, 2(2), 164-174.
Forton DM, Patel N, Prince M, Oatridge A, Hamilton G, Goldblatt J, Allsop JM, Hajnal JV, Thomas HC, Bassendine M, Jones DEJ, Taylor-Robinson SD. Fatigue and primary biliary cirrhosis: Association of globus pallidus magnetisation transfer ratio measurements with fatigue severity and blood manganese levels. Gut 2004, 53(4), 587-592.
Jones DEJ. Addison's other disease: Primary biliary cirrhosis as a model autoimmune disease. Clinical Medicine 2003, 3(4), 351-356.
Goldblatt J, Jones DEJ. Fatigue in PBC. Gastroenterology 2003, 124(2), 582.
Vidali M, Stewart SF, Rolla R, Daly AK, Chen Y, Mottaran E, Jones DEJ, Leathart JB, Day CP, Albano E. Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease. Hepatology 2003, 37(2), 410-419.
Jones DEJ, Donaldson PT. Genetic factors in the pathogenesis of primary biliary cirrhosis. Clinics in Liver Disease 2003, 7(4), 841-864.
Prince MI, Mitchison H, Ashley D, Burke DA, Edwards N, Bramble M, James OFW, Jones DEJ. Oral antioxidant supplementation for fatigue associated with primary biliary cirrhosis. Alimentary Pharmacology and Therapeutics 2003, 17(1), 137-143.
McRae CA, Prince MI, Hudson M, Day CP, James OFW, Jones DEJ. Pain as a complication of use of opiate antagonists for symptom control in cholestasis. Gastroenterology 2003, 125(2), 591-596.
Jones DEJ. Pathogenesis of primary biliary cirrhosis. Journal of Hepatology 2003, 39(4), 639-648.
Kirby JA, Bone M, Robertson H, Hudson M, Jones DEJ. The number of intraepithelial T cells decreases from ascending colon to rectum [1]. Journal of Clinical Pathology 2003, 56(2), 158-.
Jones DEJ. Complications of cholestasis. Medicine 2002, 30(12), 67-68.
Jones DEJ, Palmer JM, Robe A, Kirby JA. Oral tolerisation to pyruvate dehydrogenase complex as a potential therapy for primary biliary cirrhosis. Autoimmunity 2002, 35(8), 537-544.
Newton JL, James OFW, Bassendine MF, Jones DEJ. Osteoporosis is not a specific complication of primary biliary cirrhosis. Gut 2002, 50, 898-899.
Palmer JM, Kirby JA, Jones DEJ. The immunology of primary biliary cirrhosis: The end of the beginning?. Clinical and Experimental Immunology 2002, 129(2), 191-197.
Jones DEJ, Prince MI. Antioxidants and chronic liver disease. Nutrition Practitioner 2001, 3, 42-43.
Newton J, Francis R, Prince M, James O, Bassendine M, Rawlings D, Jones D. Osteoporosis in primary biliary cirrhosis revisited. Gut 2001, 49(2), 282-287.
Jones DEJ. Recent advances in autoimmune diseases. Journal of the Royal College of Physicians (London) 2000, 34(3), 302-305.
Palmer JM, Diamond AG, Yeaman SJ, Bassendine MF, Jones DEJ. T cell responses to the putative dominant autoepitope in primary biliary cirrhosis (PBC). Clinical and Experimental Immunology 1999, 116(1), 113-139.
Jones DEJ, Watt FE, Grove J, Newton JL, Daly AK, Gregory WL, Day CP, James OFW, Bassendine MF. Tumour necrosis factor-α promoter polymorphisms in primary biliary cirrhosis. Journal of Hepatology 1999, 30(2), 232-236.
Zappala F, Grove J, Watt FE, Daly AK, Day CP, Bassendine MF, Jones DEJ. No evidence for involvement of the interleukin-10 -592 promoter polymorphism in genetic susceptibility to primary biliary cirrhosis. Journal of Hepatology 1998, 28, 820-823.
Jones DEJ, Barton J, Cobden I. Painless small bowel ischemia presenting with diarrhoea and weight loss. American Journal of Gastroenterology 1998, 93, 653-655.
Jones DEJ, Metcalf JV, Collier JD, Bassendine MF, James OFW. Hepatocellular carcinoma in primary biliary cirrhosis and its impact on outcomes. Hepatology 1997, 26, 1138-42.
Jones DEJ, Yeaman SJ, Diamond AG, Bassendine MF. T-cell responses to Tuberculin-purified protein derivative in primary biliary cirrhosis: evidence for defective T-cell function. Gut 1997, 40, 277-283.
Jones DEJ. T-cell autoimmunity in primary biliary cirrhosis. Clinical Science 1996, 91, 551-558.
Anderson K, Jones DEJ, Wilton K, Newton JL. Restless leg syndrome is a treatable cause of sleep disturbance and fatigue in primary biliary cirrhosis. Liver International 2013, 33(2), 239-243.
Lamb CA, O'Boyle G, Jones DE, Mansfield JC, Kirby JA. Blockade of the B7 integrin prevents adherence of t lymphocytes to MAdCAM-1 in an in vitro model of vascular microcirculation post-capillary shear flow. In: Digestive Disorders Federation Meeting. 2012, Liverpool, UK: BMJ Group.
Hollingsworth KG, Macgowan GA, Morris L, Bates MG, Taylor R, Jones DE, Newton JL, Blamire AM. Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study. Journal of Applied Physiology 2012, 112(12), 2043-2048.
Frith J, Fattakhova G, Jones DEJ, Henderson E, Wilton K, Day CP, Newton JL. Cognitive impairment in non-cirrhotic chronic liver disease is unrelated to liver disease severity but associated with ineffective baroreflex function. Gut 2012, 61(7), 1101-1103.
Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day DB, Heneghan MA, Neuberger JM, Donaldson PT, Bathgate AJ, Burroughs A, Davies MH, Jones DE, Alexander GJ, Barrett JC, Sandford RN, Anderson CA, UK Primary Biliary Cirrhosis PBC C, Wellcome Trust Case Control Consor. Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nature Genetics 2012, 44(10), 1137-1141.
Liu JZ, Al Marri M, Gaffney D, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day D, Heneghan MA, Neuberger J, Donaldson PT, Bathgate A, Burroughs AK, Davies MH, Jones DE, Alexander GJ, Barrett JC, Sandford RN, Anderson CA. Dense fine-mapping study identifies novel disease loci and implicates coding and non-coding variation in primary Mary cirrhosis risk. In: 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2012, Boston, Massachusetts, USA: Wiley-Blackwell Publishing Ltd.
Frith J, Kerr S, Robinson L, Elliott CS, Wilton K, Jones DEJ, Day CP, Newton JL. Falls and Fall-Related Injury Are Common in Older People with Chronic Liver Disease. Digestive Diseases and Sciences 2012, 57(10), 2697-2702.
Hale M, Newton JL, Jones DEJ. Fatigue in primary biliary cirrhosis. British Medical Journal 2012, 345(1), e7004.
Jones D, Stephens S, Yates L, Dunstan H, Richardson JL, Greenall A, Thomas SHL. Fetal Outcomes Following Dosulepin Overdose in Pregnancy. In: International Congress of the European Association of Poisons Centres and Clinical Toxicologists. 2012, London, UK: Informa Healthcare.
Jones D, Stephens S, Yates L, Dunstan H, Richardson JL, Greenall A, Thomas SHL. Fetal Outcomes Following Fentanyl Exposure in Pregnancy. In: International Congress of the European Association of Poisons Centres and Clinical Toxicologists. 2012, London, UK: Informa Healthcare.
Jones DEJ, Hollingsworth KG, Jakovljevic DG, Fattakhova G, Pairman J, Blamire AM, Trenell MI. Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: A case control study. European Journal of Clinical Investigation 2012, 42(2), 186-194.
Leckie P, Tritto G, Mookerjee R, Davies N, Jones D, Jalan R. Out-patient' albumin dialysis for cholestatic patients with intractable pruritus. Alimentary Pharmacology and Therapeutics 2012, 35(6), 696-704.
Jones DEJ. Pathogenesis of cholestatic itch: Old questions, new answers, and future opportunities. Hepatology 2012, 56(4), 1194-1196.
Mells G, Alexander G, Jones D, Sandford R, Cordell H, UK PBC Consortium. Pathway analysis of the UK GWAS dataset implicates key immunoregulatory pathways in the pathogenesis of primary biliary cirrhosis. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
Prentis JM, Trenell MI, Jones DJ, Lees T, Clarke M, Snowden CP. Submaximal exercise testing predicts perioperative hospitalization after aortic aneurysm repair. Journal of Vascular Surgery 2012, 56(6), 1564-1570.
Patanwala I, Walton R, Mells G, Newton J, Alexander G, Hudson M, Jones D. The clinical impact of varices and a new externally validated non-invasive inexpensive tool to predict their presence in patients with PBC. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
Marschall HU, Luketic V, Lovgren-Sandblom A, Benthin L, Kowdley K, Hirschfield G, Mason A, Lindor K, Gordon S, Vincent C, Chapman R, Mayo M, Burroughs A, Pares A, Jones D, Schramm C, Eliot L, Hofmann AF, Shapiro D. The Farnesoid X receptor (FXR) agoinst obeticholic acid (OCA) increases plasma FGF-19 concentrations and decreases bile acid synthesis in primary biliary cirrhosis (PBC). In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
Jones DEJ. A potential retroviral aetiology for mouse PBC: More answers or more questions?. Journal of Hepatology 2011, 55(4), 750-752.
Patanwala I, Walter R, Mells GF, Kometa S, Newton JL, Alexander GJ, Hudson M, Jones DE. An externally-validated clinical tool for the prediction of gastro-oesophageal varices in patients with PBC - the Newcastle varices in PBC (NVP) score. In: Hepatology: 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2011, San Francisco, California, USA: John Wiley & Sons, Inc.
Kowdley KV, Jones D, Luketic V, Chapman R, Burroughs A, Hirschfield G, Poupon R, Schramm C, Vincent C, Rust C, Pares A, Mason A, Sciacca C, Beecher-Jones T, Bohm O, Castelloe E, Pruzanski M, Shapiro D, OCA PBC Study Grp. An international study evaluating the farnesoid X receptor agonist obeticholic acid as montherapy in PBC. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
Jones D, Patanwala I, Newton J. Comparison of the PBC-40 and PBC-27 tools for quality of life assessment in English speaking primary biliary cirrhosis patients. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2011, Birmingham, UK: BMJ Group.
Newton JL, Elliott C, Frith J, Ghazala C, Pairman J, Jones DEJ. Functional capacity is significantly impaired in primary biliary cirrhosis and is related to orthostatic symptoms. European Journal of Gastroenterology and Hepatology 2011, 23(7), 566-572.
Prentis J, Jones DE, Trenell MI, Snowden CP. Impaired cardiorespiratory reserve in primary biliary cirrhosis patients undergoing liver transplant assessment. In: Hepatology: 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2011, San Francisco, California, USA: John Wiley & Sons, Inc.
Patanwala I, Walter R, Newton JL, Hudson M, Jones DE. Morbidity and mortality associated with varices in patients with primary biliary cirrhosis. In: Hepatology: 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2011, San Francisco, California, USA: John Wiley & Sons, Inc.
Miller N, Deane K, Jones D, Noble E, Gibb C. National survey of speech and language therapy provision for people with Parkinson’s disease in the United Kingdom: therapists’ practices. International Journal of Language and Communication Disorders 2011, 46(2), 189-201.
Lamb CA, Price M, Jones DE, Mansfield JC. Patients with Crohn's Disease report high levels of fatigue during a symptomatic disease flare. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2011, Birmingham, UK: BMJ Group.
Elliott C, Frith J, Pairman J, Jones DEJ, Newton JL. Reduction in functional ability is significant postliver transplantation compared with matched liver disease and community dwelling controls. Transplant International 2011, 24(6), 588-595.
Jones D, Newton J. Reply to: Do fatigue and UDCA therapy truly have independent effects on mortality in PBC?. Journal of Hepatology 2011, 55(3), 729-730.
Miller N, Noble E, Jones D, Deane K, Gibb C. Survey of speech and language therapy provision for people with Parkinson’s disease in the United Kingdom: patients’ and carers’ perspectives. International Journal of Language and Communication Disorders 2011, 46(2), 179-188.
Jones DEJ, Newton JL. The Complexity of Fatigue. Hepatology 2011, 53(2), 717-718.
Palmer J, Patanwala I, Henderson E, Day CP, Jones DE. Allo- and auto-antibody responses in ALD as biomarkers of prognosis. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
Mells GF, Floyd JA, Morley KI, Alexander GJ, Cordell HJ, Donaldson PT, Heneghan MA, Jones DE, Neuberger J, Anderson CA, Sandford RN. Genome-wide association study identifies more than 10 primary biliary cirrhosis risk loci. In: Hepatology: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Hollingsworth KG, Newton JL, Patanwala I, Taylor R, Blamire AM, Jones DE. Impaired subendocardial myofibre in primary biliary cirrhosis. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
Frith J, Elliott C, Pairman J, Patanwala I, Jones DE, Newton JL. Liver transplantation is not associated with significant improvement in functional ability or symptoms. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
Frith J, Kerr S, Robinson L, Elliott C, Ghazala C, Wilton K, Pairman J, Jones D, Newton J. Primary biliary cirrhosis is associated with falls and significant fall related injury. QJM 2010, 103(3), 153-161.
Newton J, Jones D. Reply. Occupational Medicine 2010, 60(8), 666-667.
Ellis EL, Jones DE, Day CP. The significance of autoantibodies in non-alcoholic fatty liver disease. In: Hepatology: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Mells GF, Cordell HJ, Ducker SJ, Muriithi AW, Wheater EF, Alexander GJ, Donaldson PT, Heneghan MA, Jones DE, Neuberger J, Sandford RN. Validation of the north american genome-wide association study of primary biliary cirrhosis and identification of additional genetic susceptibility loci in a British cohort. In: Hepatology: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Frith J, Robinson L, Jungerius D, Pairman J, Wilton K, Jones DEJ, Newton JL. Orthostatic grading scale is better than timed up and go at identifying fallers with primary biliary cirrhosis. In: Age and Ageing: British Geriatrics Society Spring Meeting. 2008, Brighton: Oxford University Press.
Jones DEJ, Robe A, Palmer J, Kirby JA. Adoptive transfer of self-PDC reactive T-cells into naive mice induces portal tract and bile duct changes characteristic of primary biliary cirrhosis (PBC). In: 41st Annual Meeting of the European Association for the Study of the Liver. 2006, Vienna, Austria: ELSEVIER SCIENCE BV.
Ward C, Murphy D, Forrest I, Jones D, Pritchard G, Stovold R, Fisher A, Cawston T, Lordan J, Corris P. The phosphodiesterase type IV (PDE IV) inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells derived from lung transplant recipients. In: Journal of Heart and Lung Transplantation: 26th Annual Meeting of the International Society for Heart and Lung Transplantation. 2006, Madrid, Spain: Elsevier Inc.
Forrest IA, Murphy DM, Lordan JL, Pritchard G, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Ward C, Corris PA. Epithelial to mesenchymal transition in clinically stable lung transplant recipients. In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation. 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
Stewart SF, Jones DEJ, Vidali M, Haugk B, Burt AD, Albano E, Day CP. Correlation between anti-CYP2E1 titre and lymphocyte infiltration in ALD - An autoimmune disease in some patients?. In: Journal of Hepatology: 39th Annual Meeting of the European Association for the Study of the Liver. 2004, Berlin, Germany: Elsevier BV.
Baragiotta A, Floreani A, Agarwal K, Venturi C, Craggs A, Jones DEJ, Donaldson PT, Bassendine MF. No evidence for involvement of the CCR5 (chemokine receptor-5) delta 32 mutation in primary biliary cirrhosis. Liver International 2004, 24(6), 646-650.
Prince MI, Mitchison HC, Ashleigh D, Burke D, Edwards M, Bramble MG, James OFW, Jones DEJ. A placebo controlled randomised crossover trial of oral antioxidant supplementation for fatigue in primary biliary cirrhosis (PBC). In: Gut: Annual Meeting of the British Association for the Study of the Liver. 2003, Newcastle upon Tyne, UK: BMJ Group.
Perrow KA, Taylor JJ, James OFW, Bassendine MF, Jones DEJ, Donaldson PT. Caspase 8 gene polymorphism is associated with primary biliary cirrhosis. In: Gut: Annual Meeting of the British Association for the Study of the Liver. 2003, Newcastle upon Tyne, UK: BMJ Group.
Macdonald P, Jones DEJ, Kirby JA. Cell-surface expression of PDC during apoptosis: A possible route for autoantigen presentation in PBC?. In: Gut: Annual Meeting of the British Association for the Study of the Liver. 2003, Newcastle upon Tyne, UK: BMJ Group.
McRae C, Prince MI, Goldblatt J, Craig WL, Jones DEJ. Fatigue in anti-mitochondrial antibody positive patients with normal liver function tests. In: Gut: Annual Meeting of the British Association for the Study of the Liver. 2003, Newcastle upon Tyne, UK: BMJ Group.
McHugh A, Palmer JM, Yeaman SJ, Jones DEJ. Is PDC-E3BP (protein X) a T-cell autoantigen in primary biliary cirrhosis?. In: Hepatology: 54th Annual Meeting of the American Association for the Study of Liver Disease. 2003, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Jones DEJ, Walter R, Prince MI, Hudson M. The Mayo prognostic score fails to predict increased mortality associated with portal hypertension in primary biliary cirrhosis (PBC). In: Gut: Annual Meeting of the British Association for the Study of the Liver. 2003, Newcastle upon Tyne, UK: BMJ Group.
Robe AJ, Palmer JM, Kirby JA, Bassendine MF, Jones DEJ. [abstract] Characterisation of liver infiltrating T-cell antigen specificity in a mouse model of primary biliary cirrhosis (PBC). Gut 2002, 50(s2), A116 abstract no. 428.
Prince M, Mitchison HC, Ashley D, Burke DA, Edwards M, Bramble MG, James OF, Jones DE. A placebo controlled randomised crossover trial of oral antioxidant supplementation for fatigue in primary biliary cirrhosis (PBC). In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Palmer JM, Stewart S, Kirby J, Jones D. Breakdown of tolerance is seen to both PDC-E2 and PDC-E3BP, individual antigens in primary biliary cirrhosis, in a mouse model of PDC autoreactivity. In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Perrow KA, Taylor JJ, James O, Bassendine M, Jones D, Donaldson P. Caspase 8 gene polymorphism is associated with primary biliary cirrhosis. In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Macdonald P, Kirby JA, Jones DE. Cell-surface expression of pyruvate dehydrogenase complex during apoptosis: A possible route for autoantigen presentation in primary biliary cirrhosis. In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Robe A, Palmer J, Kirby J, Jones D. Characterisation of liver infiltrating T-cell antigen specificity in a mouse model of primary biliary cirrhosis (PBC). In: Journal of Hepatology. 2002, Elsevier BV.
McRae CA, Prince MI, Goldblatt J, Craig WL, Jones DE. Fatigue in anti-mitochondrial antibody positive patients with normal liver function tests. In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Agarwal K, Jones DEJ, Burt AD, Hudson M, James OFW. Metastatic breast carcinoma presenting as acute liver failure and portal hypertension. American Journal of Gastroenterology 2002, 97(3), 750-751.
Newton J, Jones D. Osteoporosis in primary biliary cirrhosis. Panminerva Medica 2002, 44(4), 335-341.
Forton D, Prince M, Allsop J, Patel N, Goldblatt J, Thomas H, Bassendine M, Jones D, Taylor-Robinson S. Reduced pallidal magnetisation transfer ratios are associated with fatigue in pre-cirrhotic patients with primary biliary cirrhosis (PBC). In: Journal of Hepatology. 2002, Elsevier BV.
Forton DM, Prince M, Allsop J, Patel N, Goldblatt J, Thomas HC, Bassendine M, Jones DEJ, Taylor-Robinson SD. Reduced pallidal magnetisation transfer ratios are associated with fatigue in pre-cirrhotic patients with primary biliary cirrhosis [abstract]. Gut 2002, 50(s2), A46 abstract no. 164.
Jones DEJ, Walter R, Prince MI, Hudson M. The impact of portal hypertension in primary biliary cirrhosis (PBC). Gut 2002, 50(s2), A118-A119 abstract no. 438.
Jones DE, Walter R, Prince M, Hudson M. The mayo prognostic score fails to predict increased mortality associated with portal hypertension in primary biliary cirrhosis. In: Hepatology: 53rd Annual Meeting of the Association for the Study of Liver Diseases. 2002, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
Jones DEJ, Walter R, Prince MI, Hudson M. The prevalence of portal hypertension (PHT) in primary biliary cirrhosis (PBC) [abstract]. Gut 2002, 50(s2), A113 abstract no. 417.
Stewart SF, Daly AK, Chen Y, Leathart JB, Jones DEJ, Rolla R, Vay D, Mottaran E, Vidali M, Albano E, Day CP. A polymorphism in CTLA-4 is associated with the presence of anti-CYP2E1 antibody titres in patients with alcoholic liver disease. Journal of Hepatology 2001, 34(1), 200.
Watt FE, Bassendine MF, James OFW, Jones DEJ. A population based study of autoimmunity in primary biliary cirrhosis (PBC) patients and their families: Evidence for a shared susceptibility. In: JOURNAL OF HEPATOLOGY. 2001.
Stewart S, Jones D, Day CP. Alcoholic liver disease: New insights into mechanisms and preventative strategies. Trends in Molecular Medicine 2001, 7(9), 408-413.
Palmer JM, Yeaman SJ, Jones DEJ. Epitope specificity of anti-PDC E1 alpha antibodies in primary biliary cirrhosis (PBC). In: Journal of Hepatology. 2001, Elsevier BV.
Jones DE, Robe AJ, Palmer JM, Kirby JA. Exploration of the immunogenicity of the primary biliary cirrhosis autoantigen pyuvate dehydrogenase complex. Hepatology 2001, 34, 730.
Goldblatt J, James OFW, Jones DEJ. Failure to sustain peripheral muscle activity as an aetiological factor for fatigue in primary biliary cirrhosis (PBC). In: Journal of Hepatology. 2001, Elsevier BV.
Johns E, Goldblatt J, Jones DE, Newton JL. Fatigue in primary biliary cirrhosis is associated with early autonomic failure. In: Hepatology. 2001, John Wiley & Sons, Inc.
Baragiotta AM, Floreani A, Jones D, Venturi C, Agarwal K, James OFW, Donaldson PTD, Bassendine MF. Genetic susceptibility to primary biliary cirrhosis (PBC): Analysis of chemokine receptor 5 (CCR5) delta32 deletion. In: Journal of Hepatology. 2001, Elsevier BV.
Goldblatt J, James OFW, Jones DEJ. Grip strength and subjective fatigue in patients with primary biliary cirrhosis [4]. Journal of the American Medical Association 2001, 285(17), 2196-2197.
Bassendine MF, Palmer JM, Yeaman SJ, Kirby JA, Jones DEJ. Immunological aspects of chronic cholestatic liver diseases. In "FALK Workshop on Hepatobiliary Diseases: Cholestasis and Gallstones" pp 32-41 Eds. Acalovschi and Paumgartner Pub. Kluwer Academic Publishers<br>(Chapter) 2001.
Prince MI, Jones DEJ. Measuring fatigue in medically unwell and distressed patients. Current Opinion in Psychiatry 2001, 14(6), 585-590.
Neill D, Hughes D, Leake A, Morris C, Jones D, Oakley A, Edwardson J, Estibeiro P. Neuritogenic-neurotoxic effects of membrane-associated forms of amyloid precursor protein. Dementia and Geriatric Cognitive Disorders 2001, 12(1), 40-51.
Robe AJ, Palmer JM, Kirby JA, Jones DE. No role for autoreactive antibody in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex, the autoantigen in primary biliary cirrhosis. In: Hepatology. 2001, John Wiley & Sons, Inc.
Finlayson NDC, Tomlinson S, Weetman AP, Connell JMC, Hill AVS, Savage CO, Wiles CM, Williams B, Ireland J, Vallance P, Whyte M, Seckl JR, Jung R, McKillop JH, Stout RW, Atkinson AB, Tomkin GH, Adgey AAJ, Axon ATR, Beck P, Eastwood JB, Fitzgerald M, Godman MJ, Heath DA, Kendall MJ, MacGregor GA, Petrie JC, Ell RGG, Allan RN, Barry RE, Boulton Jones JM, Evans CC, George CF, Heading RC, Jewell DP, Lazarus JH, Parker AC, Rawlins MD, Thurston H, Cappuccio FP, Conlon CP, John CS, Dornhurst A, Douglas JG, Elborn JS, El-Omar E, Friedland JS, Gilks CF, Groves RW, Hall AS, Hawkey CJ, Hillhouse E, Hughes J, Isaacs J, Jardine AG, Jodrell DI, Jones DEJ, Monson JP, Price P, Pugh CW, Ray DW, Santis G, Satsangi J, Scott DGI, Scott DL, Vickers MA, Wardlaw A. The ninety-fifth annual general meeting of the association of physicians of Great Britain and Ireland 2001. In: The ninety-fifth annual general meeting of the association of physicians of Great Britain and Ireland. 2001, Edinburgh: Oxford University Press.
Walter R, Agarwal K, Jackson R, Rose J, Hudson M, Jones DE. TIPSS in PBC: Lessons regarding the role played by variceal bleeding in disease prognosis. In: Journal of Hepatology. 2001, Elsevier BV.
Baragiotta AM, Floreani A, James O, Venturi C, Craggs A, Mega A, Jones D, Newton J, Bassendine M, Donaldson P. Vitamin D receptor (VDR) TaqI polymorphism in primary biliary cirrhosis (PBC). In: Journal of Hepatology. 2001, Elsevier BV.
Jones DEJ. Autoantigens in primary biliary cirrhosis. Journal of Clinical Pathology 2000, 53(11), 813-821.
Yeamon SJ, Kirby JA, Jones DEJ. Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis. Immunological Reviews 2000, 174(1), 238-249.
Agarwal K, Czaja AJ, Jones DEJ, Donaldson PT. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type 1 autoimmune hepatitis. Hepatology 2000, 31(1), 49-53.
Agarwal K, Czaja AJ, Jones DEJ, Donaldson PT. Cytotoxic T lymphocyte antigen-4 gene polymorphisms and susceptibility to type 1 autoimmune hepatitis. Hepatology 2000, 31(1), 49-53.
Jones DE. Fetal microchimerism: an aetiological factor in primary biliary cirrhosis?. Journal of Hepatology 2000, 33(5), 834-837.
Burt AD, Jones DEJ, Palmer JM, Kirby JA, Cruz DeDJ, McCaughan GW, Sedgewick JD, Yeaman SJ, Bassendine MF. Histopathology of experimental autoimmune cholangitis - a mouse model of primary biliary cirrhosis. Journal of Pathology 2000, 190, 3A-3A.
Bennett KM, Robertson H, Bone M, Burt AD, Kirby JA, Jones DE. Immunohistochemical analaysis of portal tract changes in experimental autoimmune cholangitis, a murine model of non-suppurative destructive cholangitis (NSDC). In: HEPATOLOGY. 2000.
Newton JL, Rawlings D, Prince MI, James OFW, Bassendine MF, Jones DEJ. Osteoporosis is not a specific complication of primary biliary cirrhosis (PBC). In: JOURNAL OF HEPATOLOGY. 2000.
Agarwal K, Jackson R, Rose J, Jones DE, James OF, Hudson M. PBC and portal hypertension: Is TIPS a successful bridge to transplant? A single centre retrospective review. In: HEPATOLOGY. 2000.
Prince MI, Jones DEJ. Primary biliary cirrhosis: New perspectives in diagnosis and treatment. Postgraduate Medical Journal 2000, 76(894), 199-206.
Palmer JM, Doshi M, Kirby JA, Yeaman SJ, Bassendine MF, Jones DEJ. Secretory autoantibodies in primary biliary cirrhosis (PBC). Clinical and Experimental Immunology 2000, 122(3), 423-428.
Prince MI, Jones DE, Metcalf JV, Craig W, James OF. Symptom development and prognosis of initially asymptomatic primary biliary cirrhosis (PBC). In: HEPATOLOGY. 2000.
Robe A, Palmer JM, Yeaman SJ, Jones DEJ. The E3BP (protein X) component of pyruvate dehydrogenase complex (PDC) is not a T-cell autoantigen in primary biliary cirrhosis (PBC). In: JOURNAL OF HEPATOLOGY. 2000.
Prince MI, James OFW, Holland NP, Jones DEJ. Validation of a fatigue impact score in primary biliary cirrhosis: towards a standard for clinical and trial use. Journal of Hepatology 2000, 32(3), 368-373.
Howel D, Metcalf JV, Gray J, Newman WL, Jones DEJ, James OFW. Cancer risk in primary biliary cirrhosis: A study in northern England. Gut 1999, 45(5), 756-760.
Watson JP, Jones DEJ, James OFW, Cann PA, Bramble MG. Case report: Oral antioxidant therapy for the treatment of primary biliary cirrhosis: A pilot study. Journal of Gastroenterology and Hepatology 1999, 14(10), 1034-1040.
Palmer JM, Jones DEJ, Quinn J, McHugh A, Yeaman SJ. Characterization of the autoantibody responses to recombinant E3 binding protein (protein X) of pyruvate dehydrogenase in primary biliary cirrhosis. Hepatology 1999, 30(1), 21-26.
Jones DE. Co-sensitisation with self- and homologous foreign-antigen as a mechanism of breakdown of self-tolerance in primary biliary cirrhosis (PBC). In: Gut. 1999, BMJ Group.
Agarwal K, Thursz M, Jones DEJ, Daly A, Yallop R, Bassendine MF, Hencore IVHE Grp. CTLA-4 gene polymorphism and chronicity in viral hepatitis. In: Gut. 1999, BMJ Group.
Agarwal K, Jones DE, Czaja AJ, Donaldson PT. CTLA-4 gene polymorphism and susceptibility to autoimmune hepatitis. In: Hepatology. 1999, John Wiley & Sons, Inc.
Agarwal K, Jones DEJ, Aithal G, Daly A, Bassendine MF, Hudson M. CTLA-4 gene polymorphism and susceptibility to inflammatory bowel disease (IBD). In: Gut. 1999, BMJ Group.
Jones DEJ, James OFW, Portmann B, Burt AD, Williams R, Hudson M. Development of autoimmune hepatitis following liver transplantation for primary biliary cirrhosis. Hepatology 1999, 30(1), 53-57.
Jones DEJ, Watt FE, Metcalf JV, Bassendine MF, James OFW. Familial primary hiliary cirrhosis reassessed: A geographically-based population study. Journal of Hepatology 1999, 30(3), 402-407.
Palmer JM, Kirby JA, Yeaman SJ, Doshi M, Jones DE. Persistence of secretory autoantibodies in PBC patients post-liver transplant: a potential mechanism for disease recurrence?. In: Hepatology. 1999, John Wiley & Sons, Inc.
Prince MI, Osborne JS, Ingoe L, Jones DE, Cobden I, Barton JR. The CLO test in the UK: inappropriate reading and missed results. European Journal of Gastroenterology and Hepatology 1999, 11(11), 1251-1254.
Agarwal K, Jones DEJ. Treatment of hepatitis C infection - Review underplayed important public health issues. British Medical Journal 1999, 319(7207), 450-451.
Jones DEJ, James OFW, Bassendine MF. Primary biliary cirrhosis: clinical and associated autoimmune features and natural history. Clinics in Liver Disease 1998, 2(2), 265-282.
Carbone M, Mells GF, Pells G, Dawwas MF, Newton JL, Heneghan MA, Neuberger JM, Day DB, Ducker SJ, Sandford RN, Alexander GJ, Jones DEJ, UK PBC Consortium. Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid. Gastroenterology 2013, 144(3), 560-569.

Newcastle University

Newcastle Biomedicine

Professor David Jones Dean of Translational Research

Professor David Jones
Dean of Translational Research