Dr Helen ArthurSenior Lecturer
Email: helen.arthur@ncl.ac.uk Telephone: +44 (0) 191 241 8648 Address: Institute of Human Genetics
Tan HL, Glen E, Topf A, Hall D, O'Sullivan JJ, Sneddon L, Avery P, Lewis RJ, ten Dijke P, Arthur HM, Goodship JA, Keavney BD. Non-synonymous variants in the SMAD6 gene exhibit impaired inhibition of BMP signalling and predispose to congenital cardiovascular malformation .
Human Mutation 2012, (epub ahead of print).
Watkins SJ, Borthwick GM, Oakenfull R, Robson A, Arthur HM. Angiotensin II-induced cardiomyocyte hypertrophy in vitro is mediated by Smad-independent TGFβ1 signalling through TAK1 .
Hypertension Research 2012. In Press.
Mahmoud M, Upton P, Arthur HM. Angiogenesis Regulation by TGFbeta signalling: clues from an inherited vascular disease .
Biochemical Society Transactions 2011, 39 (6), 1659-1666.
Arthur HM, Bamforth SD. TGF beta Signaling and Congenital Heart Disease: Insights from Mouse Studies .
Birth Defects Research Part A: Clinical and Molecular Teratology 2011, 91 (6), 423-434.
Jonker L, Arthur HM. Endoglin expression in early development is associated with vasculogenesis and angiogenesis .
Mechanisms of Development 2002, 110 (1-2), 193-196.
Torsney E, Charlton R, Parums D, Collis M, Arthur HM. Inducible expression of human endoglin during inflammation and wound healing in vivo .
Inflammation Research 2002, 51 (9), 464-470.
Arthur HM, Ure J, Smith AJH, Renforth G, Wilson DI, Torsney E, Charlton R, Parums DV, Jowett T, Marchuk DA, Burn J, Diamond AG. Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development .
Developmental Biology 2000, 217 (1), 42-53.
Watkins SJ, Borthwick GM, Arthur HM. The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro .
In Vitro Cellular & Developmental Biology: Animal 2011, 47 (2), 125-131.
Mahmoud M, Allinson KR, Zhai ZH, Oakenfull R, Ghandi P, Adams RH, Fruttiger M, Arthur HM. Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin .
Circulation Research 2010, 106 (8), 1425-1433.
Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Breant C, Mathivet T, Larrivee B, Thomas JL, Arthur HM, Westermann CJJ, Disch F, Mager JJ, Snijder RJ, Eichmann A, Mummery CL. Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia .
Nature Medicine 2010, 16 (4), 420-U101.
Robson A, Allinson KR, Anderson RH, Henderson DJ, Arthur HM. The TGF beta Type II Receptor Plays a Critical Role in the Endothelial Cells During Cardiac Development .
Developmental Dynamics 2010,239 9 2435-2442.
Mahmoud M, Borthwick GM, Hislop A, Arthur HM. Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH .
Laboratory Investigation 2009, 89 (1), 15-25.
Thomas HE, Avery PJ, Ahmed JM, Edwards R, Purcell I, Zaman AG, Arthur HM, Keavney BD. Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis .
Heart 2009,95 7 555-558.
Thomas HE, Redgrave R, Cunnington MS, Avery P, Keavney BD, Arthur HM. Circulating endothelial progenitor cells exhibit diurnal variation .
Arteriosclerosis, Thrombosis, and Vascular Biology 2008, 28 (3), E21-E22.
Ten Dijke P, Arthur HM. Extracellular control of TGFβ signalling in vascular development and disease .8 (11), 857-869.
Allinson KR, Carvalho RLC, Van Den Brink S, Mummery CL, Arthur HM. Generation of a floxed allele of the mouse endoglin gene .
Genesis: The Journal of Genetics and Development 2007, 45 (6), 391-395.
Watkins SJ, Jonker L, Arthur HM. A direct interaction between TGFβ activated kinase 1 and the TGFβ type II receptor: Implications for TGFβ signalling and cardiac hypertrophy .
Cardiovascular Research 2006, 69 (2), 432-439.
Van Laake LW, Van Den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, Mager JJ, Snijder RJ, Westermann CJJ, Doevendans PA, Van Echteld CJA, Ten Dijke P, Arthur HM, Goumans M-J, Lebrin F, Mummery CL. Endoglin has a crucial role in blood cell-mediated vascular repair .
Circulation 2006, 114 (21), 2288-2297.
Borthwick GM, Johnson AS, Partington M, Burn J, Wilson R, Arthur HM. Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism .
The FASEB Journal 2006, 20 (12), 2009-2016.
Carvalho RLC, Jonker L, Goumans M-J, Larsson J, Bouwman P, Karlsson S, ten Dijke P, Arthur HM, Mummery CL. Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: A paradigm for hereditary haemorrhagic telangiectasia .
Development 2004,131 24 6237-6247.
Lebrin F, Goumans M-J, Jonker L, Carvalho RLC, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM, Ten Dijke P. Endoglin promotes endothelial cell proliferation and TGF-β/ALK1 signal transduction .
EMBO Journal 2004,23 20 4018-4028.
Xu B, Wu YQ, Huey M, Arthur HM, Marchuk DA, Hashimoto T, Young WL, Yang G-Y. Vascular Endothelial Growth Factor Induces Abnormal Microvasculature in the Endoglin Heterozygous Mouse Brain .
Journal of Cerebral Blood Flow and Metabolism 2004,24 2 237-244.
Torsney E, Charlton R, Diamond AG, Burn J, Soames JV, Arthur HM. Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality .
Circulation 2003,107 12 1653-1657.
