Newcastle University

Introduction

Co-Director and Industry Lead / NIHR DeNDRoN National Coordinating Centre

NIHR Senior Investigator

Clinical Co-Director Newcastle BRC on Ageing

Background

Research Interests

I am a founding member of Newcastle University's Institute for Ageing and Health (IAH), a large inter-disciplinary research group spanning molecular mechanisms of cell ageing to clinical intervention studies. Our main research strategies centre upon longitudinal clinical assessment of patients with neurodegenerative disorders with follow up to death and request for brain autopsy. My own studies focused upon Lewy body disease have contributed to the development of globally used Consensus criteria for the clinical and pathological diagnosis and management of dementia with Lewy bodies (DLB) and related disorders. I am a longstanding member of UK MRC CFAS www.cfas.ac.uk/ and have led several international multicentre trials of diagnostic and treatments agents.

Current Work

Co-Director and Industry Lead for UK Dementias and Neurodegenerative Diseases Clinical Research Network (DeNDRoN) www.dendron.org.uk/

Research Roles

Clinical Co-Director of Newcastle NIHR Biomedical Research Centre on Ageing

NIHR Inaugural Senior Investigator of the Faculty

Co-Director of National Co-ordinating Centre of UK Dementias and Neurodegenerative Diseases Research Network (DeNDRoN)

Lead for International Consortium on Dementia with Lewy Bodies

Esteem Indicators

Lifetime Achievement Award 2009 UK Royal College of Psychiatrists

• Stephan BC, Matthews FE, Ma B, Muniz G, Hunter S, Davis D, McKeith IG, Foster G, Ince PG, Brayne C. Alzheimer and Vascular Neuropathological Changes Associated with Different Cognitive States in a Non-Demented Sample. Journal of Alzheimer's Disease 2012, 29(2), 309-318.
• Howard R, McShane R, Lindesay J, Ritchie C, Baldwin A, Barber R, Burns A, Dening T, Findlay D, Holmes C, Hughes A, Jacoby R, Jones R, Jones R, McKeith I, Macharouthu A, O'Brien J, Passmore P, Sheehan B, Juszczak E, Katona C, Hills R, Knapp M, Ballard C, Brown R, Banerjee S, Onions C, Griffin M, Adams J, Gray R, Johnson T, Bentham P, Phillips P. Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease. New England Journal of Medicine 2012, 366(10), 893-903.
• Keage HAD, Ince PG, Matthews FE, Wharton SB, McKeith IG, Brayne C, MRC CFAS CC75C. Impact of Less Common and "Disregarded" Neurodegenerative Pathologies on Dementia Burden in a Population-Based Cohort. Journal of Alzheimer's Disease 2012, 28(2), 485-493.
• Taylor J-P, Firbank M, He J, Barnett N, Pearce S, Livingstone A, Vuong Q, McKeith IG, O'Brien JT. Investigation of the visual cortex in dementia with Lewy bodies using magnetic resonance imaging. British Journal of Psychiatry 2012. In Press.
• Stephan BC, Matthews FE, Hunter S, Savva GM, Bond J, McKeith IG, Ince P, Brayne C, Medical Research Council Cognitive Function and Ageing Study. Neuropathological Profile of Mild Cognitive Impairment from a Population Perspective. Alzheimer Disease and Associated Disorders 2012, (epub ahead of print).
• Reeve AK, Park TK, Jaros E, Campbell GR, Lax NZ, Hepplewhite PD, Krishnan KJ, Elson JL, Morris CM, McKeith IG, Turnbull DM. Relationship Between Mitochondria and α-Synuclein: A Study of Single Substantia Nigra Neurons. Archives of Neurology 2012, 69(3), 385-393.
• Killen AJ, Firbank MJ, Collerton D, Clarke MP, Jeffries J, Taylor J-P, McKeith IG, Mosimann U. The assessment of cognition in visually impaired older adults. Age and Ageing 2012. In Press.
• Collerton D, Collerton J, Jagger J, Bond J, Saxby BK, Brooker H, McKeith IG, Kirkwood T. Cognitive Performance in a UK Cohort of 85 Year Olds: The Newcastle 85+ Study. In: Journal of Psychophysiology: International Conference “Aging & Cognition”. 2011, Dortmund, Germany: Hogrefe Publishing Corp.
• Baborie A, Griffiths TD, Jaros E, McKeith IG, Burn DJ, Richardson A, Ferrari R, Moreno J, Momeni P, Duplessis D, Pal P, Rollinson S, Pickering-Brown S, Thompson JC, Neary D, Snowden JS, Perry R, Mann DMA. Pathological correlates of frontotemporal lobar degeneration in the elderly. Acta Neuropathologica 2011, 121(3), 365-371.
• Narayan SK, Saxby BK, Firbank MJ, O'Brien JT, Harrington F, McKeith IG, Hansrani M, Stansby G, Ford GA. Plasma homocysteine and cognitive decline in older hypertensive subjects. International Psychogeriatrics 2011, 23(10), 1607-1615.
• Taylor J-P, McKeith IG. The Lewy Body Dementia Spectrum (Alpha Synucleinopathies). In: Abou-Saleh, M.M., Katona, C.L.E., Kumar, A., ed. Principles and Practice of Geriatric Psychiatry. Chichester, UK: Wiley-Blackwell, 2011, pp. chapter 58.
• Taylor JP, Firbank M, Barnett N, Pearce S, Livingstone A, Mosimann U, Eyre JA, McKeith IG, O'Brien JT. Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation study. British Journal of Psychiatry 2011, 199, 492-500.
• McKeith I. Adjunct treatment with levodopa in a patient with dementia with Lewy bodies, delusions and severe neuroleptic hypersensitivity syndrome: Some comments. International Psychogeriatrics 2010, 22(4), 680.
• Hutchings D, Vanoli A, McKeith I, Brotherton S, Mcnamee P, Bond J. Cholinesterase inhibitors and alzheimer's disease: Patient, carer and professional factors influencing the use of drugs for Alzheimer's disease in the United Kingdom. Dementia 2010, 9(3), 427-443.
• Hutchings D, Vanoli A, McKeith I, Brotherton S, Mcnamee P, Bond J. Good days and bad days: The lived experience and perceived impact of treatment with cholinesterase inhibitors for Alzheimer's disease in the United Kingdom. Dementia 2010, 9(3), 409-425.
• Matthews F, Muniz-Terrera G, McKeith I, Brayne C. Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance. International Journal of Geriatric Psychiatry 2010, 25(7), 719-724.
• Colloby SJ, Firbank MJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED, O'Brien JT. Alterations in nicotinic alpha4beta2 receptor binding in vascular dementia using 123I-5IA-85380 SPECT: Comparison with regional cerebral blood flow. Neurobiology of Aging 2009, 9.
• McKeith I. Commentary, DLB and PDD: the same or different? Is there a debate?. International Psychogeriatrics 2009,21 2 220-224.
• O'Brien JT, McKeith IG, Walker Z, Tatsch K, Booij J, Darcourt J, Marquardt M, Reininger C. Diagnostic accuracy of ¹²³I-FP-CIT SPECT in possible dementia with Lewy bodies. British Journal of Psychiatry 2009, 194(1), 34-39.
• Molloy S, Minett T, O'Brien JT, McKeith IG, Burn DJ. Levodopa Use and Sleep in Patients with Dementia with Lewy Bodies. Movement Disorders 2009, 24(4), 609-612.
• Byford M, Brayne C, McKeith I, Chatfield M, Ince PG, Matthews FE, MRC CFAS Neuropathology Group. Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study.. BMC Geriatrics 2009, 9(22), 9.
• Savva GM, Zaccai J, Matthews FE, Davidson JE, McKeith I, Brayne C, Medical Research Council Cognitive Function and Ageing Study. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population.. British Journal of Psychiatry 2009, 194, 212-219.
• Colloby SJ, Firbank MJ, Pakrasi SE, Lloyd JJ, Driver I, McKeith IG, Williams ED, O'Brien JT. A comparison of Tc-99m-exametazime and I-123-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies. International Psychogeriatrics 2008, 20(6), 1124-1140.
• Mosimann UP, Collerton D, Dudley R, Meyer TD, Graham G, Dean JL, Bearn D, Killen A, Dickinson L, Clarke MP, McKeith IG. A semi-structured interview to assess visual hallucinations in older people. International Journal of Geriatric Psychiatry 2008, 23(7), 712-718.
• Mukaetova-Ladinska EB, Milne J, Andras A, Abdel-All Z, Cerejeira J, Greally E, Robson J, Jaros E, Perry R, McKeith IG, Brayne C, Xuereb J, Cleghorn A, Doherty J, McIntosh G, Milton I. Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. Dementia and Geriatric Cognitive Disorders 2008, 26(1), 32-42.
• Saxby BK, Harrington F, Wesnes K, McKeith IG, Ford GA. Candesartan and cognitive decline in older patients with hypertension: A substudy of the SCOPE trial. Neurology 2008, 70(19), 1858-1866.
• Wilcock GK, Black SE, Hendrix SB, Zavitz KH, Swaab EA, Laughlin MA, on behalf of the Tarenflurbil Phase II Study Investigators. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. Lancet Neurology 2008, 7(6), 483-493.
• Stephan BC, Brayne C, McKeith IG, Bond J, Matthews FE, Medical Research Council Cognitive Function and Ageing Study. Mild cognitive impairment in the older population: Who is missed and does it matter?. International Journal of Geriatric Psychiatry 2008, 23(8), 863-871.
• O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED. Nicotinic α4β2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations. NeuroImage 2008, 40(3), 1056-1063.
• Zaccai J, Brayne C, McKeith I, Matthews F, Ince PG. Patterns and stages of α-synucleinopathy: Relevance in a population-based cohort. Neurology 2008, 70(13), 1042-1048.
• Taylor J-P, Rowan EN, Lett DJ, O'Brien JT, McKeith IG, Burn DJ. Poor attentional function predicts cognitive decline in non-demented Parkinson's disease patints independent of motor phenotype. Journal of Neurology, Neurosurgery and Psychiatry 2008,79 12 1318-1323.
• Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, Williams ED, McKeith IG, O'Brien JT. The effects of donepezil on nicotinic receptor status in dementia: A ¹²³I-5IA-85380 SPECT study. Journal of Neurology, Neurosurgery and Psychiatry 2008. , 79(4), 485-487.
• Matthews FE, Stephan BC, McKeith IG, Bond J, Brayne C, Medical Research Council Cognitive Function and Ageing Study. Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?. Journal of the American Geriatrics Society 2008, 56(8), 1424-1433.
• Moreira T, Hughes JC, Kirkwood TBL, May CR, McKeith IG, Bond J. What explains variations in the clinical use of mild cognitive impairment (MCI) as a diagnostic category?. International Psychogeriatrics 2008, 20(4), 697-709.
• Collerton J, Collerton D, Arai Y, Barrass K, Eccles M, Jagger C, McKeith I, Saxby BK, Kirkwood T, Bond J, James O, Robinson L, Von Zglinicki T. A comparison of computerized and pencil-and-paper tasks in assessing cognitive function in community-dwelling older people in the Newcastle 85+ pilot study. Journal of the American Geriatrics Society 2007, 55(10), 1630-1635.
• Taylor JP, Colloby SJ, McKeith IG, Burn DJ, Williams D, Patterson J, O'Brien JT. Cholinesterase inhibitor use does not significantly influence the ability of I-123-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies. Journal of Neurology, Neurosurgery and Psychiatry 2007, 78(10), 1069-1071.
• Bhasin M, Rowan E, Edwards K, McKeith I. Cholinesterase inhibitors in dementia with Lewy bodies - A comparative analysis. International Journal of Geriatric Psychiatry 2007, 22(9), 890-895.
• Ballard CG, Chalmers KA, Todd C, McKeith IG, O'Brien JT, Wilcock G, Love S, Perry EK. Cholinesterase inhibitors reduce cortical A beta in dementia with Lewy bodies. Neurology 2007, 68(20), 1726-1729.
• Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, Mizuno Y, Broe GA, Cummings J, Dickson DW, Gauthier S, Goldman J, Goetz C, Korczyn A, Lees A, Levy R, Litvan I, McKeith I, Olanow W, Poewe W, Quinn N, Sampaio C, Tolosa E, Dubois B. Clinical diagnostic criteria for dementia associated with Parkinson's disease. Movement Disorders 2007. , 22(12), 1689-1707.
• McKeith I. Dementia with Lewy bodies. Psychiatry 2007, 7(1), 20-23.
• Weisman D, McKeith I. Dementia with Lewy bodies. Seminars in Neurology 2007, 27(1), 42-47.
• McKeith I. Dementia with Lewy bodies and Parkinson's disease with dementia: where two worlds collide.. Practical Neurology 2007. , 7(6), 374-382.
• Walker Z, Jaros E, Walker RWH, Lee L, Costa DC, Livingston G, Ince PG, Perry R, McKeith I, Katona CLE. Dementia with Lewy bodies: A comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. Journal of Neurology, Neurosurgery and Psychiatry 2007, 78(11), 1176-1181.
• Dubois B, Burn D, Goetz C, Aarsland D, Brown RG, Broe GA, Dickson D, Duyckaerts C, Cummings J, Gauthier S, Korczyn A, Lees A, Levy R, Litvan I, Mizuno Y, McKeith IG, Olanow CW, Poewe W, Sampaio C, Tolosa E, Emre M. Diagnostic procedures for Parkinson's disease dementia: Recommendations from the Movement Disorder Society Task Force. Movement Disorders 2007. , 22(16), 2314-2324.
• Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM-Y, Leverenz JB, Masliah E, McKeith IG, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK. DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers. Neurology 2007. , 68(11), 812-819.
• Stephan BC, Matthews FE, McKeith IG, Bond J, Brayne C, Medical Research Council Cognitive Function and Aging Study. Early cognitive change in the general population: how do different definitions work?. Journal of the American Geriatrics Society 2007, 55(10), 1534-1540.
• Rowan E, McKeith IG, Saxby BK, O'Brien JT, Burn D, Mosimann U, Newby J, Daniel S, Sanders J, Wesnes K. Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 2007, 23(3), 161-167.
• Ziabreva I, Ballard C, Johnson M, Larsen JP, McKeith I, Perry R, Aarsland D, Perry E. Loss of Musashi1 in Lewy body dementia associated with cholinergic deficit. Neuropathology and Applied Neurobiology 2007, 33(5), 586-590.
• Pakrasi S, Colloby SJ, Firbank MJ, Perry EK, Wyper DJ, Owens J, McKeith IG, Williams ED, O'Brien JT. Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT. Journal of Neurology 2007, 254(7), 907-913.
• Matthews FE, Stephan BC, Bond J, McKeith I, Brayne C, Medical Research Council Cognitive Function and Ageing Study. Operationalization of mild cognitive impairment: a graphical approach. PLoS Medicine 2007, 4(10), 1615-1619.
• Matthews FE, McKeith I, Bond J, Brayne C. Reaching the population with dementia drugs: What are the challenges?. International Journal of Geriatric Psychiatry 2007, 22(7), 627-631.
• Waldemar G, Dubois B, Emre M, Georges J, McKeith IG, Rossor M, Scheltens P, Tariska P, Winblad B. Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline. European Journal of Neurology 2007. COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA: WILEY-BLACKWELL PUBLISHING, INC, 14(1), E1-E26.
• Piggott MA, Ballard CG, Rowan E, Holmes C, McKeith IG, Jaros E, Perry RH, Perry EK. Selective loss of dopamine d2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline. Synapse 2007, 61(11), 903-911.
• McKeith I, O'Brien J, Walker Z, Tatsch K, Booij J, Darcourt J, Padovani A, Giubbini R, Bonuccelli U, Volterrani D, Holmes C, Kemp P, Tabet N, Meyer I, Reininger C. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurology 2007, 6(4), 305-313.
• Boddy F, Rowan EN, Lett D, O'Brien JT, McKeith IG, Burn DJ. Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy Bodies and Alzheimer's disease. International Journal of Geriatric Psychiatry 2007, 22(6), 529-535.
• Piggott MA, Ballard CG, Dickinson HO, McKeith IG, Perry RH, Perry EK. Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia. International Journal of Neuropsychopharmacology 2007, 10(2), 231-244.
• Myers AJ, Pittman AM, Zhao AS, Rohrer K, Kaleem M, Marlowe L, Lees A, Leung D, McKeith IG, Perry RH, Morris CM, Trojanowski JQ, Clark C, Karlawish J, Arnold S, Forman MS, Van Deerlin V, de Silva R, Hardy J. The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Neurobiology of Disease 2007, 25(3), 561-570.
• O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED. α4β2 nicotinic receptor status in Alzheimer's disease using 123I-5IA-85380 single-photon-emission computed tomography. Journal of Neurology, Neurosurgery and Psychiatry 2007, 78(4), 356-361.
• Mosimann UP, Rowan EN, Partington CE, Collerton D, Littlewood E, O'Brien JT, Burn DJ, McKeith IG. Characteristics of visual hallucinations in Parkinson disease dementia and dementia with Lewy bodies. American Journal of Geriatric Psychiatry 2006, 14(2), 153-160.
• Burns A, O'Brien J, BAP Dementia Consensus Group:, Ford GA, McKeith IG, Thomas AJ, et al. Clinical practice with anti-dementia drugs: A consensus statement from British Association for Psychopharmacology. Journal of Psychopharmacology 2006. , 20(6), 732-755.
• McKeith IG. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop. Journal of Alzheimer's Disease 2006,9 Suppl. 3 417-423.
• Ballard C, Ziabreva I, Perry R, Larsen JP, O'Brien J, McKeith I, Perry E, Aarsland D. Differences in neuropathologic characteristics across the Lewy body dementia spectrum. Neurology 2006, 67(11), 1931-1934.
• Molloy SA, Rowan EN, O'Brien JT, McKeith IG, Wesnes K, Burn DJ. Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies. Journal of Neurology, Neurosurgery and Psychiatry 2006, 77(12), 1323-1328.
• Burn D, Emre M, McKeith I, De Deyn PP, Aarsland D, Hsu CC, Lane R. Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease. Movement Disorders 2006, 21(11), 1899-1907.
• Maurer K, McKeith I, Cummings J, Ames D, Burns A. Has the management of Alzheimer's disease changed over the past 100 years?. Lancet 2006, 368(9547), 1619-1621.
• Colloby SJ, Pakrasi S, Firbank MJ, Perry EK, Piggott MA, Owens J, Wyper DJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT. In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) ¹²³I-QNB in dementia with Lewy bodies and Parkinson's disease dementia. NeuroImage 2006, 33(2), 423-429.
• Ziabreva I, Ballard CG, Aarsland D, Larsen JP, McKeith IG, Perry RH, Perry EK. Lewy body disease: Thalamic cholinergic activity related to dementia and parkinsonism. Neurobiology of Aging 2006. , 27(3), 433-438.
• McKeith IG, Rowan E, Askew K, Naidu A, Allan L, Barnett N, Lett D, Mosimann UP, Burn D, O'Brien JT. More severe functional impairment in dementia with Lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction. American Journal of Geriatric Psychiatry 2006, 14(7), 582-588.
• Burn DJ, Rowan EN, Allan LM, Molloy S, O'Brien JT, McKeith IG. Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies. Journal of Neurology, Neurosurgery and Psychiatry 2006, 77(5), 585-589.
• Mukaetova-Ladinska EB, McKeith IG. Pathophysiology of synuclein aggregation in Lewy body disease. Mechanisms of Ageing and Development 2006, 127(2), 188-202.
• Burton EJ, McKeith IG, Burn DJ, Firbank MJ, O'Brien JT. Progression of white matter hyperintensities in Alzheimer disease, dementia with Lewy bodies, and Parkinson disease dementia: a comparison with normal aging. American Journal of Geriatric Psychiatry 2006, 14(10), 842-849.
• Gotti C, Moretti M, Bohr I, Ziabreva I, Vailati S, Longhi R, Riganti L, Gaimarri A, McKeith IG, Perry RH, Aarsland D, Larsen JP, Sher E, Beattie R, Clementi F, Court JA. Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation. Neurobiology of Disease 2006, 23(2), 481-489.
• Pimlott SL, Piggott M, Ballard C, McKeith I, Perry R, Kometa S, Owens J, Wyper D, Perry E. Thalamic nicotinic receptors implicated in disturbed consciousness in dementia with Lewy bodies. Neurobiology of Disease 2006, 21(1), 50-56.
• Allan L, McKeith I, Ballard C, Kenny RA. The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life. Dementia and Geriatric Cognitive Disorders 2006, 22(3), 230-237.
• Thomas AJ, Burn DJ, Rowan EN, Littlewood E, Newby J, Cousins D, Pakrasi S, Richardson J, Sanders J, McKeith IG. A comparison of the efficacy of donepezil in parkinson's disease with dementia and dementia with lewy bodies. International Journal of Geriatric Psychiatry 2005, 20(10), 938-944.
• Vollbach H, Heun R, Morris CM, Edwardson JA, McKeith IG, Jessen F, Schulz A, Maier W, Kolsch H. APOA1 polymorphism influences risk for early-onset nonfamiliar AD. Annals of Neurology 2005,58 3 436-441.
• Nowotny P, Hinrichs AL, Smemo S, Kauwe JSK, Maxwell T, Holmans P, Hamshere M, Turic D, Jehu L, Hollingworth P, Moore P, Bryden L, Myers A, Doil LM, Tacey KM, Gibson AM, McKeith IG, Perry RH, Morris CM, Thal L, Morris JC, O'Donovan MC, Lovestone S, Grupe A, Hardy J, Owen MJ, Williams J, Goate A. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 2005, 136(1), 62-68.
• Court JA, Johnson M, Religa D, Keverne J, Kalaria R, Jaros E, McKeith IG, Perry R, Naslund J, Perry EK. Attenuation of A beta deposition in the entorhinal cortex of normal elderly individuals associated with tobacco smoking. Neuropathology and Applied Neurobiology 2005. ,31 5 522-535.
• McKeith I, Cummings J. Behavioural changes and psychological symptoms in dementia disorders. Lancet Neurology 2005. ,4 11 735-742.
• Wesnes KA, McKeith I, Edgar C, Emre M, Lane R. Benefits of rivastigmine on attention in dementia associated with Parkinson disease. Neurology 2005,65 10 1654-1656.
• Burton EJ, McKeith IG, Burn DJ, O'Brien JT. Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging. Movement Disorders 2005, 20(12), 1571-1576.
• O'Brien JT, Firbank MJ, Mosimann UP, Burn DJ, McKeith IG. Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies. Psychiatry Research - Neuroimaging 2005, 139(2), 79-88.
• Bohr IJ, Ray MA, McIntosh JM, Chalon S, Guilloteau D, McKeith IG, Perry RH, Clementi F, Perry EK, Court JA, Piggott MA. Cholinergic nicotinic receptor involvement in movement disorders associated with Lewy body diseases. An autoradiography study using [I-125]alpha-conotoxinMII in the striatum and thalamus. Experimental Neurology 2005, 191(2), 292-300.
• Religa D, Johnson M, Kalaria R, Jaros E, McKeith IG, Perry R, Court JA, Naslund J, Perry EK. Decreased levels of amyloid beta peptide in the brains of smokers. In: European Journal of Neurology: 9th Congress of the EFNS. 2005, Athens, Greece: Wiley-Blackwell Publishing Ltd.
• McKeith I. Dementia with Lewy bodies. Psychiatry 2005,4 1 52-55.
• McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VMY, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M. Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology 2005. ,65 12 1863-1872.
• Ames D, Ballard C, Cream J, Shah A, Suh GH, McKeith I. For Debate: Should novel antipsychotics ever be used to treat the behavioral and psychological symptoms of dementia (BPSD)?. International Psychogeriatrics 2005,17 1 3-29.
• Geser F, Wenning GK, Poewe W, McKeith I. How to diagnose dementia with Lewy bodies: State of the art. Movement Disorders 2005. ,20 12 S11-S20.
• Firbank MJ, Molloy S, McKeith IG, Burn DJ, O'Brien JT. Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year. Journal of Neurology, Neurosurgery and Psychiatry 2005,76 10 1448-1451.
• Firbank MJ, Burn DJ, McKeith IG, O'Brien JT. Longitudinal study of cerebral blood flow SPECT in Parkinson's disease with dementia, and dementia with Lewy bodies. International Journal of Geriatric Psychiatry 2005, 20(8), 776-782.
• Teaktong T, Piggott MA, Mckeith IG, Perry RH, Ballard CG, Perry EK. Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies. Behavioural Brain Research 2005, 161(2), 299-305.
• Aarsland D, Perry R, Larsen JP, McKeith IG, O'Brien JT, Perry EK, Burn D, Ballard CG. Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias. Journal of Clinical Psychiatry 2005, 66(5), 633-637.
• Ballard CG, Perry RH, McKeith IG, Perry EK. Neuroleptics are associated with more severe tangle pathology in dementia with Lewy bodies. International Journal of Geriatric Psychiatry 2005,20 9 872-875.
• Colloby SJ, Williams ED, Burn DJ, Lloyd JJ, McKeith IG, O'Brien JT. Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT. European Journal of Nuclear Medicine and Molecular Imaging 2005, 32(10), 1176-1185.
• Mosimann UP, Muri RM, Burn DJ, Felblinger J, O'Brien JT, McKeith IG. Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies. Brain 2005,128 6 1267-1276.
• Tam CWC, Burton EJ, McKeith IG, Burn DJ, O'Brien JT. Temporal lobe atrophy on MRI in Parkinson disease with dementia: A comparison with Alzheimer disease and dementia with Lewy bodies. Neurology 2005, 64(5), 861-865.
• Matthews F, Brayne C, Arie T, Bond J, Copeland J, Day N, Devakumar D, Dewey M, Fairbairn A, Grimley-Evans J, Huppert F, Kay D, McCracken C, McKeith I, Morgan K, Paykel G. The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA Study.. PLoS Medicine 2005, 2(8), e193.
• Ballard C, Morris C, Kalaria R, McKeith I, Perry R, Perry E. The K variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients. Dementia and Geriatric Cognitive Disorders 2005, 19(5-6), 357-360.
• Molloy S, McKeith IG, O'Brien JT, Burn DJ. The role of levodopa in the management of dementia with Lewy bodies. Journal of Neurology, Neurosurgery and Psychiatry 2005, 76(9), 1200-1203.
• Collerton D, Perry E, McKeith I. Why people see things that are not there: A novel Perception and Attention Deficit model for recurrent complex visual hallucinations. Behavioral and Brain Sciences 2005, 28(6), 737-757.
• O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N. A Longitudinal Study of Hippocampal Volume, Cortisol Levels, and Cognition in Older Depressed Subjects. American Journal of Psychiatry 2004, 161(11), 2081-2090.
• Molloy S, O'Brien JT, McKeith IG, Burn DJ. Can parkinsonian phenotype be used to predict levodopa response in extrapyramidal syndromes with and without dementia?. In: Journal of Neurology, Neurosurgery and Psychiatry: Spring Meeting of the Association of British Neurologists. 2004, London, UK: BMJ Group.
• Burton EJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT. Cerebral atrophy in Parkinson's disease with and without dementia: A comparison with Alzheimer's disease, dementia with Lewy bodies and controls. Brain 2004,127 4 791-800.
• Ballmaier M, O'Brien JT, Burton EJ, Thompson PM, Rex DE, Narr KL, McKeith IG, DeLuca H, Toga AW. Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: Diagnosis and gender effects. NeuroImage 2004,23 1 325-335.
• Mukaetova-Ladinska EB, McKeith IG. Delirium and dementia. Medicine 2004, 32(8), 44-47.
• McKeith I. Dementia in Parkinson's disease: common and treatable. Lancet Neurology 2004. London, UK: The Lancet Publishing Group, 3(8), 456-456.
• McKeith I, Mintzer J, Aarsland D, Burn D, Chiu H, Cohen-Mansfield J, Dickson D, Dubois B, Duda JE, Feldman H, Gauthier S, Halliday G, Lawlor B, Lippa C, Lopez OL, Carlos MacHado J, O'Brien J, Playfer J, Reid W, On behalf of the International Psychogeriatric Association Expert Meeting on DLB. Dementia with Lewy bodies. Lancet Neurology 2004. ,3 1 19-28.
• McKeith IG, Mosimann UP. Dementia with Lewy bodies and Parkinson's disease. In: 8th International Symposium on the Treatment of Parkinsons Disease. 2004, Kobe, Japan: Parkinsonism & Related Disorders: Elsevier.
• O'Brien JT, Colloby S, Fenwick J, Williams ED, Firbank M, Burn D, Aarsland D, McKeith IG. Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with lewy bodies. Archives of Neurology 2004,61 6 919-925.
• McKeith IG, Wesnes KA, Perry E, Ferrara R. Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies. Dementia and Geriatric Cognitive Disorders 2004,18 1 94-100.
• O'Brien JT, Colloby S, Pakrasi S, Burn D, Williams D, Wyper D, Owens J, McKeith I. I-123-QNB SPECT demonstrates loss of cholinergic muscarinic receptors in Alzheimer's disease, but occipital increases in dementia with lewy bodies and Parkinson's disease dementia. In: Neurobiology of Aging: 9th International Conference on Alzheimers Disease and Related Disorders. 2004, Philadelphia, Pennsylvania, USA: Elsevier Inc..
• Rowan EN, Saxby BK, Askew KA, Thomas AJ, Manktelow TC, Wesner LA, McKeith IG. Improved attentional performance in DLB and PDD following donepezil treatment. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2004, Harrogate, UK: Sage Publications Ltd.
• McKeith IG. Introduction - An update on the diagnosis and treatment of dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 2004,17 s1 1-2.
• Ray M, Bohr I, McIntosh JM, Ballard C, McKeith I, Chalon S, Guilloteau D, Perry R, Perry E, Court JA, Piggott M. Involvement of alpha 6/alpha 3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [I-125]-alpha-conotoxin MII binding in the thalamus and striatum.. Neuroscience Letters 2004,372 3 220-225.
• Ballard CG, Jacoby R, Del Ser T, Khan MN, Munoz DG, Holmes C, Nagy Z, Perry EK, Joachim C, Jaros E, O'Brien JT, Perry RH, McKeith IG. Neuropathological Substrates of Psychiatric Symptoms in Prospectively Studied Patients With Autopsy- Confirmed Dementia With Lewy Bodies. American Journal of Psychiatry 2004,161 5 843-849.
• Gibson AM, Edwardson JA, Turnbull DM, McKeith IG, Morris CM, Chinnery PF. No evidence of an association between the T16189C mtDNA variant and late onset dementia. Journal of Medical Genetics 2004, 41(1), e7.
• Aarsland D, Mosimann UP, McKeith IG. Role of cholinesterase inhibitors in Parkinson's disease and dementia with Lewy bodies. Journal of Geriatric Psychiatry and Neurology 2004,17 3 164-171.
• Johnson J, Hague SM, Hanson M, Gibson A, Wilson KE, Evans EW, Singleton AA, McInerney-Leo A, Nussbaum RL, Hernandez DG, Gallardo M, McKeith IG, Burn DJ, Ryu M, Hellstrom O, Ravina B, Eerola J, Perry RH, Jaros E, Tienari P, Weiser R, Gwinn-Hardy K, Morris CM, Hardy J, Singleton AB. SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies. Neurology 2004,63 3 554-556.
• Walker Z, Costa DC, Walker RWH, Lee L, Livingston G, Jaros E, Perry R, McKeith I, Katona CLE. Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: A comparison. Neurology 2004,62 9 1568-1572.
• Colloby SJ, O'Brien JT, Fenwick JD, Firbank MJ, Burn DJ, McKeith IG, Williams ED. The application of statistical parametric mapping to I-123-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease. NeuroImage 2004, 23(3), 956-966.
• Mosimann UP, Mather G, Wesnes KA, O'Brien JT, Burn DJ, McKeith IG. Visual perception in Parkinson disease dementia and dementia with Lewy bodies. Neurology 2004,63 11 2091-2096.
• Aarsland D, Ballard C, Larsen JP, McKeith I, O'Brien J, Perry R. [abstract] Marked neuroleptic sensitivity in dementia with Lewy bodies and Parkinson's disease. Nordic Journal of Psychiatry 2003, 57(2), 94.
• Grace JB, McKeith IG, Wesnes K. A comparison of the use of carers' diaries and a computerised test battery to measure the fluctuations in patients with lewy bodies (DLB). In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2003, Cambridge, UK: Sage Publications Ltd.
• Karas GB, Burton EJ, Rombouts SARB, Van Schijndel RA, O'Brien JT, Scheltens P, McKeith IG, Williams D, Ballard C, Barkhof F. A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry. NeuroImage 2003,18 4 895-907.
• Vanoli A, McNamee P, Hutchings D, Steen N, Brotherton S, McKeith I, Bond J. An economic approach to the measurement of benefits of cholinesterase inhibitors in Alzheimer's disease. In: 32nd Annual Conference of the British Society of Gerontology. 2003, Newcastle upon Tyne, UK.
• Cousins DA, Burton EJ, Burn D, Gholkar A, McKeith IG, O'Brien JT. Atrophy of the putamen in dementia Lewy bodies but not Alzheimer's disease - An MRI study. Neurology 2003,61 9 1191-1195.
• Perry E, McKeith I, Ballard C. Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies. Neurology 2003,60 11 1852-1853.
• Pakrasi S, Mukaetova-Ladinska EB, McKeith IG, O'Brien JT. Clinical predictors of response to Acetyl Cholinesterase Inhibitors: experience from routine clinical use in Newcastle. International Journal of Geriatric Psychiatry 2003, 18(10), 879-886.
• Burn DJ, McKeith IG. Current treatment of dementia with Lewy bodies and dementia associated with Parkinson's disease. Movement Disorders 2003,18 6 S72-S79.
• McKeith IG, Burn DJ, Ballard CG, Collerton D, Jaros E, Morris CM, McLaren A, Perry EK, Perry R, Piggott MA, O'Brien JT. Dementia with Lewy bodies. Seminars in Clinical Neuropsychiatry 2003,8 1 46-57.
• Mosimann UP, McKeith IG. Dementia with Lewy bodies - diagnosis and treatment. Swiss Medical Weekly 2003. ,133 9-10 131-142.
• McKeith IG, Mosimann UP. Dementia with Lewy bodies and Parkinson's disease dementia - two synucleinopathies. Advances in Clinical Neurosciences and Rehabilitation 2003, 3(3), 8-10.
• Lippa CF, McKeith I. Dementia with Lewy bodies. Improving diagnostic criteria. Neurology 2003,60 1571-1572.
• Almeida OP, Burton EJ, Ferrier N, McKeith IG, O'Brien JT. Depression with late onset is associated with right frontal lobe atrophy. Psychological Medicine 2003,33 4 675-681.
• Saxby BK, Harrington F, McKeith IG, Wesnes K, Ford GA. Effects of hypertension on attention, memory, and executive function in older adults. Health Psychology 2003, 22(6), 587-591.
• Burn DJ, Rowan EN, Minett T, Sanders J, Myint P, Richardson J, Thomas A, Newby J, Reid J, O'Brien JT, McKeith IG. Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross-sectional comparative study. Movement Disorders 2003, 18(8), 884-889.
• McKeith IG, Masterman DL, Farlow MR, Grossberg GT. Future trends in cholinergic therapy. Geriatrics 2003, 58(s6), i-iv.
• Allan LM, McLaren AT, Allen J, Ballard CG, McKeith IG, Murray A, Kenny RA. Heart rate variability is reduced in dementia with Lewy bodies but not Alzheimer’s disease or vascular dementia. In: First Congress of the International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG). 2003, Gothenburg, Sweden.
• Almeida OP, Burton EJ, McKeith I, Gholkar A, Burn D, O'Brien JT. MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 2003,16 2 57-63.
• Shaw FE, Bond J, Richardson DA, Dawson P, Steen IN, McKeith IG, Kenny RA. Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the accident and emergency department: randomised controlled trial. British Medical Journal 2003,326 7380 6.
• Cairns NJ, Perry RH, Jaros E, Burn D, McKeith IG, Lowe JS, Holton J, Rossor MN, Skullerud K, Duyckaerts C, Cruz-Sanchez FF, Lantos PL. Patients with a novel neurofilamentopathy: dementia with neurofilament inclusions. Neuroscience Letters 2003,341 3 177-180.
• Williams JG, Huppert FA, Matthews FE, Nickson J, MRC Cognitive Function and Ageing Study (MRC CFAS). Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample. International Journal of Geriatric Psychiatry 2003, 18(7), 631-644.
• Firbank MJ, Colloby SJ, Burn DJ, McKeith IG, O'Brien JT. Regional cerebral blood flow in Parkinson's disease with and without dementia. NeuroImage 2003,20 2 1309-1319.
• O'Brien KK, Saxby BK, Ballard CG, Grace J, Harrington F, Ford GA, O'Brien JT, Swan AG, Fairbairn AF, Wesnes K, Del Ser T, Edwardson JA, Morris CM, McKeith IG. Regulation of attention and response to therapy in dementia by butyrylcholinesterase. Pharmacogenetics 2003,13 4 231-239.
• Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, McKeith IG, Quinn NP, Sethi KD. SIC Task Force Appraisal of Clinical Diagnostic Criteria for Parkinsonian Disorders. Movement Disorders 2003,18 467-486.
• Collerton D, Burn D, McKeith I, O'Brien J. Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia. Dementia and Geriatric Cognitive Disorders 2003,16 4 229-237.
• Saxby BK, Harrington F, McKeith IG, Wesnes K, Ford GA. The effect of candesartan cilexetil on cognitive function in older adults with mild hypertension. In: Journal of Hypertension: 13th European Meeting on Hypertension. 2003, Milan, Italy: Lippincott Williams & Wilkins.
• Saxby R, Harrington F, McKeith IG, Wesnes KA, Ford GA. The effect of candesartan on cognitive function in older adults with mild hypertension. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2003, Cambridge, UK: Sage Publications Ltd.
• Minett TSC, Thomas A, Wilkinson LM, Daniel SL, Sanders J, Richardson J, Littlewood E, Myint P, Newby J, McKeith IG. What happens when donepezil is suddenly withdrawn? An open label trial in dementia with Lewy bodies and Parkinson's disease with dementia. International Journal of Geriatric Psychiatry 2003,18 11 988-993.
• McKeith IG. [abstract] Diagnosis and treatment of dementia with Lewy Bodies: State of the art. American Journal of Geriatric Psychiatry 2002, 10(2, s1), 24.
• Colloby SJ, Fenwick JD, Williams ED, Paling SM, Lobotesis K, Ballard C, McKeith I, O'Brien JT. A comparison of Tc-99m-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping. European Journal of Nuclear Medicine and Molecular Imaging 2002, 29(5), 615-622.
• Burton EJ, Paling SM, Ballard CG, McKeith IG, O'Brien JT, Karas G, Scheltens P, Barkhof F, Williams ED. Cerebral atrophy in dementia with Lewy bodies studied using voxel-based morphometry. In: Neurobiology of Aging. 2002, Elsevier Inc.
• Perry EK, Piggott MA, Johnson M, Ballard CG, McKeith IG, Jaros E, Perry RH. Cholinergic and monoaminergic correlates of clinical symptoms in dementia with Lewy bodies. In: Mapping the Progress of Alzheimer's and Parkinson's Disease. 2002, Kyoto, Japan: Springer.
• Singleton AB, Wharton A, O'Brien KK, Walker MP, McKeith IG, Ballard CG, O'Brien J, Perry RH, Ince PG, Edwardson JA, Morris CM. Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 2002,14 3-4 167-175.
• SantaCruz KS, Walker Z, Swagerty D, Piggott MA, Ryo-Yang M, McKeith IG, Raghavan R, Jaros E, Perry RH. Clinical presentations in monozygotic twins with dementia with Lewy bodies. Journal of the American Medical Directors Association 2002, 3(3), 175-179.
• McKeith IG. Dementia with Lewy bodies. British Journal of Psychiatry 2002, 180(2), 144-147.
• Leverenz JB, McKeith IG. Dementia with Lewy bodies. Medical Clinics of North America 2002, 86(3), 519-535.
• Walker Z, Costa DC, Walker RWH, Shaw K, Gacinovic S, Stevens T, Livingston G, Ince P, McKeith IG, Katona CLE. Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand. Journal of Neurology, Neurosurgery and Psychiatry 2002, 73(2), 134-140.
• Ballard CG, Court JA, Piggott M, Johnson M, O'Brien J, McKeith I, Holmes C, Lantos P, Jaros E, Perry R, Perry E. Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex. Consciousness and Cognition 2002,11 3 461-474.
• Wilkinson L, Daniel S, Newby J, Thomas A, Sanders J, Myint P, Richardson J, McKeith I. Donepezil treatment and withdrawal in patients with dementia with lewy bodies (DLB) and patients with Parkinsons disease plus DLB. In: Neurobiology of Aging. 2002, Elsevier Inc.
• Wesnes KA, McKeith IG, Ferrara R, Emre M, Del Ser T, Spano PF, Cicin-Sain A, Anand R, Spiegel R. Effects of rivastigmine on cognitive function in dementia with Lewy bodies: A randomised placebo-controlled international study using the Cognitive Drug Research computerised assessment system. Dementia and Geriatric Cognitive Disorders 2002, 13(3), 183-192.
• Ballard CG, Aarsland D, McKeith I, O'Brien J, Gray A, Cormaak F, Burn D, Cassidy T, Starfeldt R, Larsen J-P, Brown R, Tovee M. Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology 2002,59 11 1714-1720.
• McKeith I. Galantamine for vascular dementia. Lancet Neurology 2002, 1(4), 210-210.
• Burn DJ, McKeith IG. Hallucinations in patients with parkinsonism: Clinical features and management. Geriatrics and Aging 2002, 5, 22-26.
• Lloyd AJ, McGuckin EA, Barnett NA, Gholkar A, McKeith IG, Young AH, Ferrier IN, O'Brien JT. Increased salivary cortisol in late- but not early-onset depression: Relationship with hippocampal volume. In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2002, Harrogate: Sage Publications Ltd.
• Perry EK, Burn DJ, McKeith IG, O'Brien J, Perry R. Lewy body diseases. In: Davis, K.L., Charney, D., Coyle, J.T., Nemeroff, C, ed. Neuropsychopharmacology: The Fifth Generation of Progress. Philadelphia: Lippincott Williams & Wilkins, 2002, pp.1301-1316.
• Husain MM, Cummings JL, Doraiswamy MP, McKeith IG. Neurobiology of behavioral disturbances in dementia: Implications for clinical practice [abstract]. American Journal of Geriatric Psychiatry 2002, 10(2, s1), 23.
• Perry EK, Piggott MA, Johnson M, Ballard CG, McKeith IG, Burn DJ. Neurotransmitter correlates of neuropsychiatric symptoms in dementia with Lewy bodies. In: Bédard, M.-A, ed. Mental & Behavioural Dysfunction in Movement Disorders. Totowa, New Jersey, USA: Humana Press Inc, 2002, pp.285-294.
• Burton EJ, Karas G, Paling SM, Barber R, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT. Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. NeuroImage 2002, 17(2), 618-630.
• Wesnes K, McKeith I, Ferrara R, Emre M, Spiegel R. Predicting response to rivastigmine in dementia with Lewy Bodies [abstract]. European Neuropsychopharmacology 2002, 12(s3), S373.
• Colloby S, Paling SM, Lobotesis K, Ballard C, McKeith IG, O'Brien JT, Fenwick JD, Williams ED. Tc-99m HMPAO SPECT image analysis in dementia with Lewy bodies and Alzheimer's disease using statistical paramentric mapping. In: Neurobiology of Aging. 2002, Elsevier Inc.
• Wesnes KA, McKeith IG. The utility of attention measurement in evaluating therapeutic responses, in cholinergic dementias [abstract]. American Journal of Geriatric Psychiatry 2002, 10(2, s1), 94.
• Johnson M, Court J, Perry E, Kalaria R, McKeith I, Jaros E, Perry R, Naslund J, Religa D. Tobacco use is associated with attenuation of beta-amyloidosis in hippocampus and entorhinal cortex of normal elderly individuals. In: Neurobiology of Aging. 2002, Elsevier Inc.
• Barber R, McKeith I, Ballard C, O'Brien J. Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia. Journal of Neurology, Neurosurgery and Psychiatry 2002,72 3 406-407.
• Aarsland D, Ballard C, Larsen JP, McKeith I. A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson's disease with and without dementia. International Journal of Geriatric Psychiatry 2001, 16(5), 528-536.
• Barber R, McKeith IG, Ballard C, Gholkar A, O'Brien JT. A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: Magnetic resonance imaging volumetric study. Dementia and Geriatric Cognitive Disorders 2001, 12(3), 198-205.
• Ballard C, O'Brien J, Gray A, Cormack F, Ayre G, Rowan E, Thompson P, Bucks R, McKeith I, Walker M, Tovee M. Attention and fluctuating attention in patients with dementia with lewy bodies and alzheimer disease. Archives of Neurology 2001, 58(6), 977-982.
• Aarsland D, Ballard C, McKeith I, Perry RH, Larsen JP. Comparison of extrapyramidal signs in dementia with Lewy bodies and Parkinson's disease. Journal of Neuropsychiatry and Clinical Neurosciences 2001, 13(3), 374-379.
• Middelkoop HAM, Van Der Flier WM, Burton EJ, Lloyd AJ, Paling S, Barber R, Ballard C, McKeith IG, O'Brien JT. Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI. Neurology 2001, 57(11), 2117-2120.
• Williams ED, Colloby SJ, Paling SM, Lobotesis K, Fenwick JD, Ballard C, McKeith I, O'Brien JT. Dementia with Lewy bodies differentiated from Alzheimer's disease on Tc-99m-HMPAO SPECT using statistical parametric mapping. In: European Journal of Nuclear Medicine. 2001.
• Barber R, Panikkar A, McKeith IG. Dementia with Lewy bodies: diagnosis and management. International Journal of Geriatric Psychiatry 2001, 16(1), S12-S18.
• Lloyd AJ, Grace JB, Jaros E, Perry RH, Fairbairn AF, Swann AG, O'Brien JT, McKeith IG. Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases. International Journal of Geriatric Psychiatry 2001, 16(3), 281-287.
• Luce A, McKeith I, Swann A, Daniel S, OBrien J. How do memory clinics compare with traditional old age psychiatry services?. International Journal of Geriatric Psychiatry 2001, 16(9), 837-845.
• Grace J, Daniel S, Stevens T, Shankar KK, Walker Z, Byrne EJ, Butler S, Wilkinson D, Woolford J, Waite J, McKeith IG. Long-term use of rivastigmine in patients with dementia with Lewy bodies: An open-label trial. International Psychogeriatrics 2001, 13(2), 199-205.
• Kalaria RN, Ince PG, Kenny RA, McKeith IG, Morris CM, O'Brien JT, Perry EK, Perry RH, Edwardson JA. Multiple substrates of late-onset dementia: implications for brain protection. Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235 2001, 235, 49-65.
• Kalaria RN, Ballard CG, Ince PG, Kenny RA, McKeith IG, Morris CM, O'Brien JT, Perry EK, Perry RH, Edwardson JA. Multiple substrates of late-onset dementia: Implications for brain protection. Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235 2001, 235, 49-65.
• Singleton AB, Gibson AM, McKeith IG, Ballard CG, Edwardson JA, Morris CM. Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies. Neuroscience Letters 2001, 303(1), 33-36.
• Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, McKeith IG, O'Brien JT. Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD. Neurology 2001, 56(5), 643-649.
• Hogan DB, McKeith IG. Of MCI and dementia: Improving diagnosis and treatment. Neurology 2001, 56(9), 1131-1132.
• Esiri MM, Matthews F, Brayne C, Ince PG, Matthews FE, Xuereb JH, Broome JC, McKenzie J, Rossi M, McKeith IG, Lowe J, Morris JH, Neuropathology Grp Med Res Council. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 2001, 357(9251), 169-175.
• O'Brien JT, Paling S, Barber R, Williams ED, Ballard C, McKeith IG, Gholkar A, Crum WR, Rossor MN, Fox NC. Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia. Neurology 2001, 56(10), 1386-1388.
• Reading PJ, Luce AK, McKeith IG. Rivastigmine in the treatment of parkinsonian psychosis anti cognitive impairment: Preliminary findings from an open trial. Movement Disorders 2001, 16(6), 1171-1174.
• Ballard C, Walker M, O'Brien J, Rowan E, McKeith I. The characterisation and impact of 'fluctuating' cognition in dementia with Lewy bodies and Alzheimer's disease. International Journal of Geriatric Psychiatry 2001, 16(5), 494-498.
• Ballard CG, O'Brien JT, Swann AG, Thompson P, Neill D, McKeith IG. The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease: Persistence and new cases over 1 year of follow-up. Journal of Clinical Psychiatry 2001, 62(1), 46-49.
• Ballard C, O'Brien J, Morris CM, Barber R, Swann A, Neill D, McKeith I. The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's disease. International Journal of Geriatric Psychiatry 2001, 16(5), 499-503.
• Grace JB, Walker MP, McKeith IG. A comparison of sleep profiles in patients with dementia with Lewy bodies and Alzheimer's disease. International Journal of Geriatric Psychiatry 2000, 15(11), 1028-1033.
• McKeith IG. Alzheimer's disease and related disorders: Etiology, pathogenesis and therapeutics. Review. Aging & Mental Health 2000, 4(1), 91-91.
• McKeith IG. Behavioral and psychological symptoms of dementia and dementia with Lewy bodies. In: International Psychogeriatrics. 2000, Cambridge University Press.
• Shaw FE, Richardson DA, Dawson P, Steen IN, McKeith IG, Bond J, Kenny RA. Can multi-disciplinary intervention prevent falls in patients with cognitive impairment and dementia attending a casualty department?. In: British Geriatrics Society Communications to the Autumn Meeting 1999. 2000, London: Oxford University Press.
• Shaw FE, Richardson DA, Dawson P, Steen IN, McKeith IG, Bond J, Kenny RA. Can multi-disciplinary intervention prevent falls in patients with cognitive impairment and dementia attending a casualty department?. Irish Journal of Medicine 2000, 169(2), 30.
• Shaw FE, Richardson DA, Steen IN, McKeith IG, Bond J, Kenny RA. Clinical characteristics of fallers with cognitive impairment and dementia who comply with multi-disciplinary post-fall intervention. Age and Ageing 2000, 29(Suppl 2), A22.
• McKeith IG. Clinical Lewy body syndromes. Annals of the New York Academy of Science: Molecular Basis of Dementia 2000, 920, 1-8.
• Harrington F, Saxby BK, McKeith IG, Wesnes K, Ford GA. Cognitive performance in hypertensive and normotensive older subjects. Hypertension 2000, 36(6), 1079-1082.
• Harrington F, Saxby BK, McKeith IG, Wesnes K, Ford GA. Cognitive performance in hypertensive and normotensive older subjects. Hypertension 2000, 36(6), 1079-1082.
• Ballard C, Piggott M, Johnson M, Cairns N, Perry R, McKeith I, Jaros E, O'Brien J, Holmes C, Perry E. Delusions associated with elevated muscarinic binding in dementia with Lewy bodies. Annals of Neurology 2000,48 6 868-876.
• Del Ser T, McKeith I, Anand R, Cicin-Sain A, Ferrara R, Spiegel R. Dementia with Lewy bodies: Findings from an international multicentre study. International Journal of Geriatric Psychiatry 2000, 15(11), 1034-1045.
• McKeith I, Del Ser T, Spano P, Emre M, Wesnes K, Anand R, Cicin-Sain A, Ferrara R, Spiegel R. Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study. Lancet 2000, 356(9247), 2031-2036.
• Ballard CG, McKeith IG, Ayre G, Gray A, Cormack F, Tovee M, O'Brien JT, Walker MP. Impairments in attention and fluctuating attention distinguish between dementia with Lewy bodies and Alzheimer's disease. Neurology 2000, 54(3), A451.
• Shaw FE, Richardson DA, Steen IN, McKeith IG, Bond J, Kenny RA. Longer term health and social outcomes in patients with cognitive impairment and dementia who attend the casualty department with a fall. In: Communications to the Spring Meeting of the British Geriatrics Society. 2000, Warwick: Oxford University Press.
• O'Brien JT, Metcalfe S, Swann A, Hobson J, Jobst K, Ballard C, McKeith I, Gholkar A. Medial temporal lobe width on CT scanning in Alzheimer's disease: Comparison with vascular dementia, depression and dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 2000, 11(2), 114-118.
• Chinnery PF, Taylor GA, Howell N, Andrews RM, Morris CM, Taylor RW, McKeith IG, Perry RH, Edwardson JA, Turnbull DM. Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies. Neurology 2000,55 2 302-304.
• Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT. MRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer's disease. International Journal of Geriatric Psychiatry 2000, 15(10), 911-916.
• Court JA, Piggott MA, Lloyd S, Cookson N, Ballard CG, McKeith IG, Perry RH, Perry EK. Nicotine binding in human striatum: Elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication. Neuroscience 2000,98 1 79-87.
• Shaw FE, Richardson DA, Steen IN, McKeith IG, Bond J, Kenny RA. Predictors of further falls in patients with cognitive impairment and dementia attending an accident and emergency facility. In: American Geriatrics Society/AFAR 2000 Annual Scientific Meeting. 2000, Nashville, TN: Wiley-Blackwell Publishing Ltd.
• Shaw FE, Richardson DA, Steen IN, Mckeith IG, Bond J, Kenny RA. Predictors of further falls in patients with cognitive impairment and dementia attending an accident and emergency facility. In: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2000.
• O'Brien JT, Paling S, Barber R, Ballard C, McKeith I. Progressive brain atrophy on serial MRI in dementia with Lewy bodies: A comparison with Alzheimer's disease and vascular dementia. Neurobiology of Aging 2000, 21(1S), S130.
• Walker MP, Ayre GA, Perry EK, Wesnes K, McKeith IG, Tovee M, Edwardson JA, Ballard CG. Quantification and characterisation of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 2000, 11(6), 327-335.
• McKeith IG. Regulatory issues concerning behavioral and psychological symptoms of dementia in Europe. International Psychogeriatrics 2000, 12, 321-326.
• McKeith IG, Grace JB, Walker Z, Byrne EJ, Wilkinson D, Stevens T, Perry EK. Rivastigmine in the treatment of dementia with Lewy bodies: Preliminary findings from an open trial. International Journal of Geriatric Psychiatry 2000, 15(5), 387-392.
• Paling S, Williams ED, LLoyd A, Barber R, Burton EJ, Gholkar A, Crum WR, Fox NC, McKeith I, Ballard C, O'Brien JT. Serial MR image registration and analysis techniques applied to studies of differential cerebral atrophy in late-onset dementia. In: International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences. 2000, Las Vegas, Nevada, USA: CSREA PRESS.
• McKeith IG, Burn D. Spectrum of Parkinson's disease, Parkinson's dementia, and lewy body dementia. Neurologic Clinics 2000, 18(4), 865-883.
• Xu WM, Liu LZ, Emson P, Harrington CR, McKeith IG, Perry RH, Morris CM, Charles IG. The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. Neuroreport 2000, 11(2), 297-299.
• Walker MP, Ayre GA, Cummings JL, Wesnes K, McKeith IG, O'Brien JT, Ballard CG. The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale - Two methods to assess fluctuating confusion in dementia. British Journal of Psychiatry 2000, 177, 252-256.
• Shikiar R, Shakespeare A, Sagnier PP, Wilkinson D, McKeith I, Dartigues JF, Dubois B. The impact of metrifonate therapy on caregivers of patients with Alzheimer's disease: Results from the MALT clinical trial. Metrifonate in Alzheimer's Disease Trial. Journal of the American Geriatrics Society 2000, 48(3), 268-274.
• Ballard C, OBrien JT, Swann A, Thompson P, Neill D, McKeith I. The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease. Journal of Clinical Psychiatry 2000, 62, 46-49.
• Dubois B, McKeith I, Orgogozo J-M, Collins O and Meulien D. A multicenre, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate Alzheimer's disease: the MALT study. International Journal of Geriatric Psychiatry 1999, 14, 973-982.
• Chapman FM, Dickinson J, McKeith I and Ballard C. Associations among visual hallucinations, visual acuity, and specific eye pathologies in AD. Treatment implications. American Journal of Psychiatry 1999, 156(12), 1983-1985.
• Atkinson A, Singleton AB, Steward A, Ince PG, Perry RH, McKeith IG, Fairbairn AF, Edwardson JA, Daly AK, Morris CM. CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease. Pharmacogenetics and Genomics 1999, 9(1), 31-36.
• McKeith I and O'Brien J. Dementia with Lewy bodies. Australian and New Zealand Journal of Psychiatry 1999, 33, 800-808.
• McKeith IG, O'Brien JT, Ballard C. Diagnosing dementia with Lewy bodies. Lancet 1999, 354(9186), 1227-1228.
• Briel RCG, McKeith IG, Barker WA, Hewitt Y, Perry RH, Ince PG and Fairbairn AF. EEG findings in dementia with Lewy bodies and Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry 1999, 66, 401-403.
• Walker Z, Costa DC, Ince P, McKeith IG and Katona CLE. In-vivo demonstration of dopaminergic degeneration in dementia with Lewy bodies. Lancet 1999, 354, 646-647.
• Court J, Spurden D, Lloyd S, McKeith I, Ballard C, Cairns N, Kerwin R, Perry R and Perry E. Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: a-bungarotoxin and nicotine binding in the thalamus. Journal of Neurochemistry 1999, 73(4), 1590-1597.
• Walker Z, Grace J, Overshot R, Satarasinghe S, Swan A, Katona CLE and McKeith IG. Olanzapine in dementia with Lewy bodies: A clinical study. International Journal of Geriatric Psychiatry 1999, 14, 459-466.
• Whitworth A, Lesser R and McKeith I. Profiling conversation in Parkinson's disease with cognitive impairment. Aphasiology 1999, 13, 407-425.
• Ballard CG, Holmes C, McKeith I, Neill D, O'Brien J, Cairns N, Lantos P, Perry E, Ince P, Perry R. Psychiatric morbidity in dementia with Lewy bodies: A prospective clinical and neuropathological comparative study with Alzheimer's disease. American Journal of Psychiatry 1999, 156(7), 1039-1045.
• McKeith IG, Perry EK and Perry RH. Report of the second dementia with Lewy body international workshop - Diagnosis and treatment. Neurology 1999, 53, 902-905.
• Ballard CG, Ayre G, O'Brien J, Sahgal A, McKeith IG, Ince PG, Perry RH. Simple standardised neuropsychological assessments aid in the differential diagnosis of dementia with Lewy bodies from Alzheimer's disease and vascular dementia. Dementia and Geriatric Cognitive Disorders 1999, 10(2), 104-108.
• Perry R.H., McKeith I.G. and Perry E.K. Lewy body dementia. Neuroscience News 1998, 1 (3), 28-35.
• McKeith IG, Ince P, Jaros EB, Fairbairn A, Ballard C, Grace J, Morris CM and Perry RH. What are the relations between Lewy body disease and AD?. Journal of Neural Transmission 1998, 107-116.
• Perry R., McKeith I., Perry E. Lewy body dementia - clinical, pathological and neurochemical interconnections. J Neural Transm 1997, 51, 95-109.
• Perry R.H., McKeith I.G. and Perry E.K. Lewy body dementia: clinical, pathological and neurochemical interconnections. J Neural Transm, PD and Dementia Section Suppl 1997, 51, 97-109.
• A. B. Singleton, H. Lamb, A. Leake, I. G. McKeith, P. G. Ince, R. H. Perry and C. M. Morris. No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies. Neuroreport 1997, 8, 3637-3639.
• A. B. Singleton, H. Lamb, A. Leake, I. G. McKeith, R. H. Perry and C. M. Morris. No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease. Neuroscience Letters 1997, 234, 19-22.
• I. G. McKeith and C. M. Morris. Apolipoprotein E genotyping in Alzheimer's disease. Lancet 1996, 347, 1775-1775.
• Burns A., Perry E.K., McKeith I.G. Correlation of cholinergic abnormalities with senilee plaques and mental test scores in senile dementia. Int J Geriatr Psychiatry 1996, 11, 765-771.