Research Groups - Newcastle Biomedicine

Dr John Mansfield
Senior Lecturer/Consultant

Email: j.c.mansfield@ncl.ac.uk
Telephone: +44 (0) 191 282 0135
Address: RVI

Publications

Lamb CA, Price M, Robinson M, Gunn MC, Thompson NP, Mansfield JC. A real life retrospective analysis of drug expenditure reveals no significant cost difference between infliximab and adalimumab in the treatment of Adult Crohn's Disease. In: Annual Meeting of the British Society of Gastroenterology. 2011, Birmingham, England: Gut: BMJ Publishing Group.
Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagace C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RSN, Floyd JAB, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panes J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genetics 2011, 43(3), 246-U94.
Lamb CA, Price M, Jones DE, Mansfield JC. Patients with Crohn's Disease report high levels of fatigue during a symptomatic disease flare. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2011, Birmingham, UK: BMJ Group.
Prescott NJ, Lehne B, Harrison K, Knight J, Weale M, Simpson M, Green P, Lewis C, Hart A, Sanderson J, Mansfield J, Schlitt T, Mathew C. Screening for rare pathogenic sequence variants in inflammatory bowel disease. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2011, Birmingham, UK: BMJ Group.
Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC, Barroso I, Barton A, Bennett AJ, Bhaskar S, Blaszczyk K, Bowes J, Brand OJ, Braund PS, Bredin F, Breen G, Brown MJ, Bruce IN, Bull J, Burren OS, Burton J, Byrnes J, Caesar S, Clee CM, Coffey AJ, Connell JMC, Cooper JD, Dominiczak AF, Downes K, Drummond HE, Dudakia D, Dunham A, Ebbs B, Eccles D, Edkins S, Edwards C, Elliot A, Emery P, Evans DM, Evans G, Eyre S, Farmer A, Ferrier IN, Feuk L, Fitzgerald T, Flynn E, Forbes A, Forty L, Franklyn JA, Freathy RM, Gibbs P, Gilbert P, Gokumen O, Gordon-Smith K, Gray E, Green E, Groves CJ, Grozeva D, Gwilliam R, Hall A, Hammond N, Hardy M, Harrison P, Hassanali N, Hebaishi H, Hines S, Hinks A, Hitman GA, Hocking L, Howard E, Howard P, Howson JMM, Hughes D, Hunt S, Isaacs JD, Jain M, Jewell DP, Johnson T, Jolley JD, Jones IR, Jones LA, Kirov G, Langford CF, Lango-Allen H, Lathrop GM, Lee J, Lee KL, Lees C, Lewis K, Lindgren CM, Maisuria-Armer M, Maller J, Mansfield J, Martin P, Massey DCO, McArdle WL, McGuffin P, McLay KE, Mentzer A, Mimmack ML, Morgan AE, Morris AP, Mowat C, Myers S, Newman W, Nimmo ER, O'Donovan MC, Onipinla A, Onyiah I, Ovington NR, Owen MJ, Palin K, Parnell K, Pernet D, Perry JRB, Phillips A, Pinto D, Prescott NJ, Prokopenko I, Quail MA, Rafelt S, Rayner NW, Redon R, Reid DM, Renwick A, Ring SM, Robertson N, Russell E, St Clair D, Sambrook JG, Sanderson JD, Schuilenburg H, Scott CE, Scott R, Seal S, Shaw-Hawkins S, Shields BM, Simmonds MJ, Smyth DJ, Somaskantharajah E, Spanova K, Steer S, Stephens J, Stevens HE, Stone MA, Su Z, Symmons DPM, Thompson JR, Thomson W, Travers ME, Turnbull C, Valsesia A, Walker M, Walker NM, Wallace C, Warren-Perry M, Watkins NA, Webster J, Weedon MN, Wilson AG, Woodburn M, Wordsworth BP, Young AH, Zeggini E, Carter NP, Frayling TM, Lee C, McVean G, Munroe PB, Palotie A, Sawcer SJ, Scherer SW, Strachan DP, Tyler-Smith C, Brown MA, Burton PR, Caulfield MJ, Compston A, Farrall M, Gough SCL, Hall AS, Hattersley AT, Hill AVS, Mathew CG, Pembrey M, Satsangi J, Stratton MR, Worthington J, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Parkes M, Rahman N, Todd JA, Samani NJ, Donnelly P, Wellcome Trust Case Control. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010, 464(7289), 713-U86.
Dipper CR, Maitra S, Thomas R, Lamb CA, McLean-Tooke APC, Ward R, Smith D, Spickett G, Mansfield JC. Anti-tissue transglutaminase antibodies in the follow-up of adult coeliac disease. Alimentary Pharmacology and Therapeutics 2009, 30(3), 236-244.
Lamb CA, Mohiuddin MK, Gicquel J, Neely D, Bergin FG, Hanson JM, Mansfield JC. Faecal calprotectin or lactoferrin can identify postoperative recurrence in Crohn's disease. British Journal of Surgery 2009, 96(6), 663-674.
Mckenna M, Mansfield JC. Safety of bisphosphonates in women of child bearing age. Alimentary Pharmacology and Therapeutics 2009, 29(11), 1214-1215.
Chapman JM, Onnie CM, Prescott NJ, Fisher SA, Mansfield JC, Mathew CG, Lewis CM, Verzilli CJ, Whittaker JC. Searching for Genotype-Phenotype Structure: Using Hierarchical Log-Linear Models in Crohn Disease. American Journal of Human Genetics 2009, 84(2), 178-187.
Prescott NJ, Fisher SA, Franke A, Hampe J, Onnie CM, Soars D, Bagnall R, Mirza MM, Sanderson J, Forbes A, Mansfield JC, Lewis CM, Schreiber S, Mathew CG. A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn's Disease and Is Independent of CARD15 and IBD5. Gastroenterology 2007, 132(5), 1665-1671.
Mansfield JC, Parkes M, Hawthorne AB, Forbes A, Probert CSJ, Perowne RC, Cooper A, Zeldis JB, Manning DC, Hawkey CJ. A randomized, double-blind, placebo-controlled trial of lenalidomide in the treatment of moderately severe active Crohn's disease. Alimentary Pharmacology and Therapeutics 2007, 26(3), 421-430.
Fisher SA, Mirza MM, Onnie CM, Soars D, Lewis CM, Prescott NJ, Mathew CG, Sanderson J, Forbes A, Todhunter C, Donaldson P, Mansfield J. Combined Evidence From Three Large British Association Studies Rejects TUCAN/CARD8 as an IBD Susceptibility Gene. Gastroenterology 2007. , 132(5), 2078-2080.
Tremelling M, Cummings F, Fisher SA, Mansfield J, Gwilliam R, Keniry A, Nimmo ER, Drummond H, Onnie CM, Prescott NJ, Sanderson J, Bredin F, Berzuini C, Forbes A, Lewis CM, Cardon L, Deloukas P, Jewell D, Mathew CG, Parkes M, Satsangi J. IL23R Variation Determines Susceptibility But Not Disease Phenotype in Inflammatory Bowel Disease. Gastroenterology 2007, 132(5), 1657-1664.
Pearce AV, Fisher S, Prescott N, Onnie C, Pattni R, Green P, Forbes A, Mansfield J, Sanderson J, Schreiber S, Lewis CM, Mathew CG. Investigation of assocaiation of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population. International Journal of Colorectal Disease 2007,22 4 419-424.
Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H, Lees CW, Khawaja SA, Bagnall R, Burke DA, Todhunter CE, Ahmad T, Onnie CM, McArdle W, Strachan D, Bethel G, Bryan C, Lewis CM, Deloukas P, Forbes A, Sanderson J, Jewell DP, Satsangi J, Mansfield JC, Cardon L, Mathew CG. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nature Genetics 2007, 39(7), 830-832.
Fisher SA, Hampe J, Onnie CM, Daly MJ, Curley C, Purcell S, Sanderson J, Mansfield J, Annese V, Forbes A, Lewis CM, Schreiber S, Rioux JD, Mathew CG. Direct or indirect association in a complex disease: The role of SLC22A4 and SLC22A5 functional variants in Crohn disease. Human Mutation 2006, 27(8), 778-785.
King K, Sheikh MF, Cuthbert AP, Fisher SA, Onnie CM, Mirza MM, Pattni RC, Sanderson J, Forbes A, Mansfield J, Lewis CM, Roberts RG, Mathew CG. Mutation, selection, and evolution of the Crohn disease susceptibility gene CARD15. Human Mutation 2006, 27(1), 44-54.
Shenderey RL, Thompson N, Mansfield JC, Rees C. Adenocarcinoma as a complication of small bowel Crohn's disease. European Journal of Gastroenterology & Hepatology 2005, 17(11), 1255-1257.
Daly MJ, Pearce AV, Farwell L, Fisher SA, Latiano A, Prescott NJ, Forbes A, Mansfield J, Sanderson J, Langelier D, Cohen A, Bitton A, Wild G, Lewis CM, Annese V, Mathew CG, Rioux JD. Association of DLG5 R30Q variant with inflammatory bowel disease. European Journal of Human Genetics 2005, 13(7), 835-839.
Balredin R, Barrett P, Wooff DA, Mansfield JC, Yiannakou Y. How Good is Zoom Endoscopy in Assessing Villous Atrophy in Coeliac Disease?. Endoscopy 2005,37 10 994-998.
Masson S, Nylander D, Mansfield JC. How important is onset of action in ulcerative colitis therapy?. Drugs 2005. ,65 15 2069-2083.
Todhunter CE, Sutherland-Craggs A, Bartram S, Donaldson PT, Daly AK, Francis RM, Mansfield JC, Thompson NP. Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease. Gut 2005, 54(11), 1579-1584.
Johnson GJ, Cosnes J, Mansfield JC. Review article: smoking cessation as primary therapy to modify the course of Crohn's disease. Alimentary Pharmacology and Therapeutics 2005. ,21 8 921-931.
Crosbie J, Varma J, Mansfield J. Yersinia enterocolitica infection in a patient with hemachromatosis masquerading as proximal colon cancer with liver metastases: Report of a case. Diseases of the Colon and Rectum 2005, 48(2), 390-392.
Wayman J, Mansfield JC, Matthewson K, Richardson DL, Griffin SM. Combined percutaneous and endoscopic procedures for bile duct obstruction: Simultaneous and delayed techniques compared. Hepato-Gastroenterology 2003,50 52 915-918.
Mirza MM, Fisher SA, King K, Cuthbert AP, Hampe J, Sanderson J, Mansfield J, Donaldson P, Macpherson AJS, Forbes A, Schreiber S, Lewis CM, Mathew CG. Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease. American Journal of Human Genetics 2003,72 4 1018-1022.
Mirza MM, Fisher SA, King K, Cuthbert AP, Hampe J, Sanderson J, Mansfield J, Donaldson P, MacPherson A, Forbes A, Schreiber S, Lewis CM, Mathew CG. Genetic evidence for interaction of the 5Q31 cytokine locus and the CARD15 gene in Crohn's disease. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2003, Birmingham, UK: BMJ Group.
Fisher SA, Moody A, Mirza MM, Cuthbert AP, Hampe J, Macpherson A, Sanderson J, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG. Genetic variation at the chromosome 16 chemokine gene cluster: Development of a strategy for association studies in complex disease. Annals of Human Genetics 2003,67 5 377-390.
King K, Moody A, Fisher SA, Mirza MM, Cuthbert AP, Hampe J, Sutherland-Craggs A, Sanderson J, MacPherson AJ, Forbes A, Mansfield JC, Schreiber S, Lewis CM, Mathew CG. Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease. International Journal of Immunogenetics 2003, 30(3), 187-190.
Gunn MC, Cavin AA, Mansfield JC. Management of irritable bowel syndrome. Postgraduate Medical Journal 2003, 79(929), 154-158.
Sutherland-Craggs A, Mansfield JC, Donaldson PT, Daly A, Francis RR, Thompson NP. Osteoporosis in Crohn's disease is not determined by vitamin D receptor and interleukin-6 genotype. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2003, Birmingham, UK: BMJ Group.
Mansfield JC. Pentasa may not be the optimal 5ASA. Gut 2003, 52(5), 771.
Jaafar A, Hawkyard C, Lapworth K, Davidson B, Ledger J, Wilkins J, Mansfield J, Thompson NP. Screening for malnutrition: Impact of the malnutrition universal screening tool (MUST). In: Gut: Annual Meeting of the British Society of Gastroenterology. 2003, Birmingham, UK: BMJ Group.
King K, Onnie C, Mirza M, Fisher S, Cuthbert A, Sanderson S, Forbes A, Mansfield J, Lewis C, Mathew C. Sequence variation in the CARD15 (nod2) gene and susceptibility to Crohn's disease. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2003, Birmingham, UK: BMJ Group.
Mansfield JC. Which 5-ASA?. Gut 2003, 52(5), 771.
Sutherland-Craggs A, Mansfield JC, Hudson M, Cuthbert A, Fisher S, Mathew C, Bartram S, Daly A, Francis R, Thompson NP. Osteoporosis in Crohn's disease is not determined by NOD2 genotype [abstract]. Gut 2002, 50(s2), A80 abstract no. 291.
Mansfield JC, Harrison-Diver V. Smoking cessation in Crohn's disease: Worthwhile results are possible [abstract]. Gut 2002, 50(s2), A75 abstract no. 273.
Green JRB, Mansfield JC, Gibson JA, Kerr GD, Thornton PC. A double-blind comparison of balsalazide, 6.75 g daily, and sulfasalazine, 3 g daily, in patients with newly diagnosed or relapsed active ulcerative colitis. Alimentary Pharmacology and Therapeutics 2002, 16(1), 61-68.
Mansfield JC, Giaffer MH, Cann PA, McKenna D, Thornton PC, Holdsworth CD. A double-blind comparison of balsalazide, 6.75 g, and sulfasalazine, 3 g, as sole therapy in the management of ulcerative colitis. Alimentary Pharmacology and Therapeutics 2002, 16(1), 69-77.
Mathew CG, Mirza M, Fisher S, King K, Hampe J, Sanderson J, Forbes A, Mansfield J, Cuthbert A, Schreiber S, Lewis CM. Contribution of genetic variants at CARD15 and the chromosome 5q31 locus to Crohn's disease. In: American Journal of Human Genetics: 52nd Annual Meeting of the American Society of Human Genetics. 2002, Baltimore, Maryland, USA: Cell Press.
Cuthbert AP, Fisher SA, Mirza MM, King K, Hampe J, Croucher PJP, Mascheretti S, Sanderson J, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 2002, 122(4), 867-874.
Craggs A, West S, Curtis A, Welfare MR, Hudson M, Donaldson PT, Mansfield JC. Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and crohn disease in multiple populations from northeast England. Scandinavian Journal of Gastroenterology 2001, 36(11), 1173-1178.
Aithal GP, Mansfield JC. Review article: The risk of lymphoma associated with inflammatory bowel disease and immunosuppressive treatment. Alimentary Pharmacology and Therapeutics 2001, 15(8), 1101-1108.
Aithal GP, Craggs A, Day CP, Welfare M, Daly AK, Mansfield JC, Hudson M. Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease. Digestive Diseases and Sciences 2001, 46(7), 1520-1525.
Craggs A, Welfare M, Donaldson PT, Mansfield JC. The CC chemokine receptor 5 Delta 32 mutation is not associated with inflammatory bowel disease (IBD) in NE England. Genes and Immunity 2001, 2(2), 114-116.
Craggs A, West SP, Curtis A, Welfare M, Hudson M, Donaldson PT, Mansfield JC. Absence of a genetic association between IL-1RN and ulcerative colitis in multiple populations from NE England. In: GUT. 2000.
Bartram SA, Hainsworth PJ, Mansfield J, Peaston R, Francis RM, Walshaw D, Thompson NP. Bone mineral density & risk factors for osteoporosis in patients with Crohn's disease. In: GASTROENTEROLOGY. 2000.
King T, Firth M, Kelly T, Huey D, Mansfield J, Plusa S. Psychological factors which influence adjustment to inflammatory bowel disease. In: GUT. 2000.
Mansfield JC. Balsalazide - A viewpoint. DRUGS 1998, 56(1), 90-90.
A. J. Leonard, J. W. W. Killen, J. C. Mansfield, G. J. Gibson, M. Hudson and N. A. G. Jones. Difficulties in diagnosis and treatment of spinal tuberculosis. Hospital Medicine 1998, 59, 656-657.
Mansfield JC, Griffin SM, Wadehra V, Matthewson K. A prospective evaluation of cytology from biliary strictures. Gut 1997, 40(5), 671-677.
Mansfield JC, Tanner AR, Bramble MG. Information for patients about inflammatory bowel disease.. Journal of the Royal College of Physicians of London 1997, 31, 184-7.
Mansfield J, Charnley R. Practice in endoscopic cholangiopancreatography in Denmark differs from that in Britain. British Medical Journal 1996. ,313 7067 1263-1264.
McManus R, Wilson AG, Mansfield J, Weir DG, Duff GW, Kelleher D. TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the celiac disease major histocompatibility complex haplotype.. European Journal of Immunology 1996, 26, 2113-8.
Mansfield JC, Giaffer MH, Holdsworth CD. Controlled trial of oligopeptide versus amino acid diet in treatment of active Crohn’s disease.. Gut 1995, 36, 60-6.
Mansfield JC, Giaffer MH, Tindale WB, Holdsworth CD. Quantitative assessment of overall inflammatory bowel disease activity using labelled leucocytes: a direct comparison between indium-111 and technetium-99m HMPAO methods. Gut 1995, 37, 679-83.
Mansfield JC, Holden H, Tarlow JK, Di Giovine FS, McDowell TL, Wilson AG, Holdsworth CD, Duff GW. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist.. Gastroenterology 1994, 106, 637-42.
Craggs A, Donaldson P, Welfare M, Thompson NP, Mansfield JC. Genetic association studies in IBD; Negative results from three candidate genes. In: British Society of Gastroenterology Annual Meeting. 2001, Glasgow, UK: BMJ Group.

Newcastle University

Newcastle Biomedicine

Dr John Mansfield Senior Lecturer/Consultant

Dr John Mansfield
Senior Lecturer/Consultant