Professor Jeffrey PearsonProfessor of Molecular Physiology
Email: jeffrey.pearson@ncl.ac.uk Telephone: +44 (0) 191 222 6996 Fax: +44 (0) 191 222 7424 Address: Institute for Cell and Molecular Biosciences
Robertson AGN, Krishnan A, Ward C, Pearson JP, Small T, Corris PA, Dark JH, Karat D, Shenfine J, Griffin SM. Anti-reflux surgery in lung transplant recipients: outcomes and effects on quality of life .
The European Respiratory Journal 2012, 39 (3), 691-697.
Aseeri A, Brodlie M, Lordan J, Corris P, Pearson J, Ward C, Manning N. Bile Acids Are Present in the Lower Airways of People with Cystic Fibrosis .
American Journal of Respiratory and Critical Care Medicine 2012, 185 (4), 463-463.
Wilson CL, Hine DW, Pradipta A, Pearson JP, van Eden W, Robinson JH, Knight AM. Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4+T helper type 1 subset differentiation .
Immunology 2012, 135 (4), 344-354.
Pearson JP, Parikh S. Review article: reflux and its consequences - the laryngeal, pulmonary and oesophageal manifestations .
In: Alimentary Pharmacology and Therapeutics: 9th International Symposium on Human Pepsin (ISHP) . 2011, Kingston upon Hull, UK: Wiley-Blackwell Publishing Ltd..
Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP. Measuring mucus thickness in reef corals using a technique devised for vertebrate applicationsMarine Biology 2010, 157 (2), 261-267.
Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP. Coral mucus: the properties of its constituent mucins .
Biomacromolecules 2010, 11 (4), 883-888.
Bulmer DM, Ali MS, Brownlee IA, Dettmar PW, Pearson JP. Laryngeal Mucosa: Its Susceptibility to Damage by Acid and Pepsin .
Laryngoscope 2010, 120 (4), 777-782.
Robertson AGN, Ward C, Pearson JP, Corris PA, Dark JH, Griffin SM. Lung Transplantation, Gastroesophageal Reflux, and Fundoplication .89 (2), 653-660.
Brodlie M, McKean MC, Johnson GE, Perry JD, Nicholson A, Verdon B, Gray MA, Dark JH, Pearson JP, Fisher AJ, Corris PA, Lordan J, Ward C. Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs .
Experimental Lung Research 2010, 36 (2), 101-110.
Pearson JP, Brownlee IA. The Interaction of Large Bowel Microflora with the Colonic Mucus Barrier .
International Journal of Inflammation 2010, Article ID 321426.
Robertson AGN, Shenfine J, Ward C, Pearson JP, Dark JH, Corris PA, Griffin SM. A Call for Standardization of Antireflux Surgery in the Lung Transplantation Population .87 (8), 1112-1114.
Brownlee IA, Seal CJ, Wilcox M, Dettmar PW, Pearson JP. Applications of Alginates in Food .
In: Rehm, BHA, ed. Alginates: Biology and applications . Berlin, Germany: Springer, 2009, pp. 211-228.
Robertson AGN, Griffin SM, Ward C, Pearson JP, Bredenoord AJ, Dark JH, Fisher AJ, Lodean J, Corris PA. Aspiration in the Immediate Post Lung Transplantation Period .
In: Journal of Heart and Lung Transplantation:29th Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation . 2009, Paris, France: Elsevier Inc..
Robertson AGN, Ward C, Pearson JP, Bredenoord AJ, Fisher AJ, Lordan J, Corris PA, Dark JH, Griffin SM. Aspiration Secondary to Gastro-Oesophageal Reflux but not Duodenal Reflux Occurs in the Immediate Post Lung Transplantation Period .
In: Transplant International: 14th Congress of the European Society for Organ Transplantation . 2009, Paris, France: Wiley-Blackwell Publishing Ltd..
Robertson AGN, Ward C, Pearson JP, Small T, Lordan J, Fisher AJ, Bredenoord AJ, Dark J, Griffin SM, Corris PA. Longitudinal changes in gastro-oesophageal reflux from 3 months to 6 months after lung transplantation .64 (11), 1005-1007.
Robertson AGN, Griffin SM, Murphy DM, Pearson JP, Forrest IA, Dark JH, Corris PA, Ward C. Targeting Allograft Injury and Inflammation in the Management of Post-Lung Transplant Bronchiolitis Obliterans Syndrome .9 (6), 1272-1278.
Stovold R, Forrest I, Murphy D, Johnston G, Lordan J, Fisher A, Dark J, Corris P, Pearson J, Ward C. Temporal Patterns of Lung Pepsin Levels in Allografts Suggest Aspiration Is an Ongoing Injury, Which Can Occur Early Following Lung Transplantation .
In: Journal of Heart and Lung Transplantation: 29th Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation . 2009, Paris, France: Elsevier Inc..
Brownlee IA, Atherton MR, Havler ME, Dettmar PW, Allen A, Pearson JP. The effect of dietary fibre intake on mucus secretion in the rat colon .
In: Williams, P.A., Phillips, G.O, ed. Gums and stabilizers for the food industry . London, UK: Royal Society of Chemistry, 2009, pp.526-534.
Stovold R, Corris PA, Fisher AJ, Lordan JL, Pearson JP, Ward C. Does pepsin in gastric juice aspirated into the lung allograft stimulate mucus hypersecretion? .
In: 28th Annual Meeting of the International Society for Heart and Lung Transplantation . 2008, Boston, MA: Journal of Heart and Lung Transplantation: Elsevier.
Stovold R, Forrest IA, Murphy DM, Johnson GE, Lordan J, Fisher AJ, Corris PA, Pearson JP, Ward C. Longitudinal assessment of pepsin levels in lung allografts suggests aspiration is an ongoing injury, which can occur early following lung transplantation .
In: Thorax: Winter Meeting of the British Thoracic Society . 2008, London, UK: BMJ Publishing Group.
Robertson AGN, Griffin SM, Ward C, Pearson JP, Bredenoord AJ, Dark JH, Fisher AJ, Lordan J, Corris PA. Qualitative and quantitative assessments of aspiration in the immediate post-lung transplantation period .
In: Thorax: Winter Meeting of the British Thoracic Society . 2008, London, UK: BMJ Publishing Group.
Decalmer S, Stovold R, Jones H, Pearson J, Ward C, Houghton LA, Kelsall A, McGuinness K, Woodcock AA, Smith JA. Relationships between micro-aspiration, gastro-oesophageal reflux and cough in chronic cough subjects .
In: British Thoracic Society Winter Meeting . 2008, London: Thorax: BMJ Publishing Group.
Brodlie M, McKean MC, Perry J, Nicholson A, Johnson GE, Pearson JP, Fisher A, Corris PA, Lordan JL, Ward C. The culture of primary bronchial epithelial cells from the lungs of people with cystic fibrosis removed at the time of transplantation: a model to study cystic fibrosis lung disease .
In: British Thoracic Society Winter Meeting 2008 . 2008, London: Thorax: BMJ Publishing Group.
Strugala V, Dettmar PW, Pearson JP. Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn's disease .
International Journal of Clinical Practice 2008, 62 (5), 762-769.
Brownlee IA, Knight J, Dettmar PW, Pearson JP. Action of reactive oxygen species on colonic mucus secretions .
Free Radical Biology and Medicine 2007, 43 (5), 800-808.
Ali MS, Wilson JA, Bennett MK, Pearson JP. Mucin gene expression in hypertrophic adenoids .
Acta Oto-Laryngologica 2007, 127 (10), 1080-1085.
Stovold R, Forrest IA, Corris PA, Murphy DM, Smith JA, Decalmer S, Johnson GE, Dark JH, Pearson JP, Ward C. Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection .
American Journal of Respiratory and Critical Care Medicine 2007, 175 (12), 1298-303.
Stovold R, Forrest IA, Corris PA, Murphy DM, Smith JA, Decalmer S, Johnson GE, Dark JH, Pearson JP, Ward C. Pepsin, a biomarker of gastric aspiration in lung allografts: A putative association with rejection .
American Journal of Respiratory and Critical Care Medicine 2007, 175 (12), 1298-1303.
Ali MS, Pearson JP. Upper airway mucin gene expression: A review .
Laryngoscope 2007, 117 (5), 932-938.
Viswanathan H, Brownlee IA, Pearson JP, Carrie S. MUC5B secretion is up-regulated in sinusitis compared with controls .
American Journal of Rhinology 2006, 20 (5), 554-557.
Brownlee IA, Dettmar PW, Strugala V, Pearson JP. The interaction of dietary fibres with the colon .2 (3), 243-264.
Brownlee IA, Allen A, Pearson JP, Dettmar PW, Havler ME, Atherton MR, Onsoyen E. Alginate as a source of dietary fiber .
Critical Reviews in Food Science and Nutrition 2005, 45 (6), 497-510.
Smirnova MG, Birchall JP, Pearson JP. Evidence of T-helper cell 2 cytokine regulation of chronic otitis media with effusion .
Acta Oto-Laryngologica 2005, 125 (10), 1043-1050.
Gill GA, Johnston N, Buda A, Pignatelli M, Pearson J, Dettmar PW, Koufman J. Laryngeal epithelial defenses against laryngopharyngeal reflux: Investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin .
Annals of Otology, Rhinology and Laryngology 2005,114 12 913-921.
Ali MS, Hutton DA, Wilson JA, Pearson JP. Major secretory mucin expression in chronic sinusitis .
Otolaryngology - Head and Neck Surgery 2005,133 3 423-428.
Ali MS, Wilson JA, Bennett M, Pearson JP. Mucin gene expression in nasal polyps .
Acta Oto-Laryngologica 2005, 125 (6), 618-624.
Ward C, Forrest IA, Brownlee IA, Johnson GE, Murphy DM, Pearson JP, Dark JH, Corris PA. Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts .
Thorax 2005, 60 (10), 872-874.
Taylor C, Pearson JP, Draget KI, Dettmar PW, Smidsrod O. Rheological characterisation of mixed gels of mucin and alginate .
Carbohydrate Polymers 2005, 59 (2), 189-195.
Pearson JP, Brownlee IA. Structure and function of mucosal surfaces .
In: Nataro, J.P., et al, ed. Colonization of Mucosal surfaces .Washington, DC:ASM Press,2005, pp. 3-16.
N'Dow, J., Jordan, N., Robson, C. N., Neal, D. E., Pearson, J. P. The bladder does not appear to have a dynamic secreted continuous mucous gel layer .
Journal of Urology 2005, 173 (6), 2025-2031.
Ward C, Headland L, Vest S, Brownlee IA, Forrest IA, Ward TA, Pritchard G, Murphy DM, Pearson JP, Dark J, Corris P. Clinically silent gastric aspiration is common in lung allografts .
In: Winter Meeting of the British Thoracic Society . 2004, London: Thorax: BMJ Publishing Group.
Paleri V, Pearson JP, Bulmer D, Jeannon JP, Wight RG, Wilson JA. Expression of much gene products in laryngeal squamous cancer .
Otolaryngology - Head and Neck Surgery 2004, 131 (1), 84-88.
Fergie N, Bayston R, Pearson JP, Birchall JP. Is otitis media with effusion the result of a biofilm infection? .
Clinical Otolaryngology 2004,29 1 38-46.
Pearson JP, Brownlee IA, Taylor C. Mucin genes in the GI tract .
In: Williams, PA ; Phillips, GO, ed. Gums and Stabilisers for the Food Industry . Cambridge: Royal Society of Chemistry, 2004, pp.517-525.
N'Dow J, Pearson J, Neal D. Mucus production after transposition of intestinal segments into the urinary tract .22 3 178-185.
Smirnova MG, Birchall JP, Pearson JP. The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion .13 2 75-88.
Keegan SJ, Graham C, Neal DE, Blum-Oehler G, N'Dow J, Pearson JP, Gally DL. Characterization of Escherichia coli strains causing urinary tract infections in patients with transposed intestinal segments .
Journal of Urology 2003,169 6 2382-2387.
Brownlee IA, Havler ME, Dettmor PW, Allen A, Pearson JP. Colonic microflora metabolites alter the protective capacity of the colonic mucus layer in vivo .
In: Gut: Annual Meeting of the British Society of Gastroenterology . 2003, Birmingham, UK: BMJ Group.
Strugala V, Allen A, Dettmar PW, Pearson JP. Colonic mucin: Methods of measuring mucus thickness .
Proceedings of the Nutrition Society 2003,62 1 237-243.
Brownlee IA, Havler ME, Dettmar PW, Allen A, Pearson JP. Colonic mucus: Secretion and turnover in relation to dietary fibre intake .
Proceedings of the Nutrition Society 2003, 62 (1), 245-249.
Brownlee IA, Atherton MA, Havler ME, Dettmar PW, Allen A, Pearson JP. Dietary fibre modulates the protective potential of the colonic mucus barrier and mucosal health .
In: Gut: Annual Meeting of the British Society of Gastroenterology . 2003, Birmingham, UK: BMJ Group.
Capper R, Guo L, Pearson JP, Birchall JP. Effect of nitric oxide donation on mucin production in vitro .
Clinical Otolaryngology and Allied Sciences 2003,28 1 51-54.
Smirnova MG, Guo L, Birchall JP, Pearson JP. LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells .
Cellular Immunology 2003,221 1 42-49.
Taylor C, Allen A, Dettmar PW, Pearson JP. The gel matrix of gastric mucus is maintained by a complex interplay of transient and nontransient associations .
Biomacromolecules 2003,4 4 922-927.
Smirnova MG, Birchall JP, Pearson JP. In vitro study of IL-8 and goblet cells: Possible role of IL-8 in the aetiology of otitis media with effusion .
Acta Oto-Laryngologica 2002,122 2 146-152.
Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Is gastric reflux a cause of otitis media with effusion in children? .
In: Laryngoscope: 105th Annual Meeting of the Triological Society . 2002, Boca Raton, Florida, USA: John Wiley & Sons, Inc.
Ali MS, Wilson JA, Pearson JP. Mixed nasal mucus as a model for sinus mucin gene expression studies .
Laryngoscope 2002,112 2 326-331.
Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Reflux of gastric juice and glue ear in children .
Lancet 2002, 359 (9305), 493.
Smirnova MG, Birchall JP, Pearson JP. Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion .
European Cytokine Network 2002, 13 (2), 161-172.
Smirnova MG, Kiselev SL, Gnuchev NV, Birchall JP, Pearson JP. Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion .
European Cytokine Network 2002, 13 (2), 161-172.
Panetti M, Pearson JP, Dettmar PW, Koufman JA. Active pepsin in airway secretions: Possible evidence for new supraesophageal pH criteria .
In: 102nd Annual Meeting of the American Gastroenterological Association . 2001, Atlanta, Georgia, USA: W.B. Saunders Co.
Axford SE, Sharp N, Ross PE, Pearson JP, Dettmar PW, Panetti M, Koufman JA. Cell biology of laryngeal epithelial defenses in health and disease .
Annals of Otology, Rhinology and Laryngology 2001, 110 (12), 1099-1108.
Axford SE, Sharp N, Ross PE, Pearson JP, Dettmar PW, Panetti M, Koufman JA. Cell biology of laryngeal epithelial defenses in health and disease: Preliminary studies .
Annals of Otology Rhinology and Laryngology 2001, 110 (12), 1099-1108.
Dixon J, Strugala V, Griffin SM, Welfare MR, Dettmar PW, Allen A, Pearson JP. Esophageal mucin: An adherent mucus gel barrier is absent in the normal esophagus but present in columnar-lined Barrett's esophagus .
American Journal of Gastroenterology 2001, 96 (9), 2575-2583.
Hanson JM, Broweil DA, Cunliffe WJ, Varma J, Allen A, Hemming D, Shenton BK, Young JR, Higgs MJ, Brotherick I, Pearson JP. MUC1 expression in primary breast cancer: The effect of tamoxifen treatment .
Breast Cancer Research and Treatment 2001, 67 (3), 215-222.
Tasker A, Murphy F, Singh AE, Dettmar PW, Birchall JP, Pearson JP. MUC5B is the viscous component of middle ear effusions .
In: 4th Extraordinary International Symposium on Recent Advances in Otitis Media . 2001, Sendai, Japan: Medimond SRL.
N'Dow J, Pearson JP, Bennett MK, Neal DE, Robs CN. Mucin gene expression in human urothelium .
Journal of Otolaryngology 2001, 166 , 219-220.
Pearson JP, Roberts NB. Mucosal protective effects of ecabet sodium: pepsin inhibition and interaction with mucus .
Clinical Science 2001, 100 (4), 411-417.
Tasker A, Dettmar PW, Birchall JP, Pearson JP. Pepsin in the middle ear - A reflux too far? .
In: 4th Extraordinary International Symposium on Recent Advances in Otitis Media . 2001, Sendai, Japan: Medimond SRL.
N'Dow, J., Robson, C. N., Matthews, J. N. S., Neal, D. E., Pearson, J. P. Reducing mucus production after urinary reconstruction: A prospective randomized trial .
Journal of Urology 2001, 165 (5), 1433-1440.
Taylor C, Allen A, Dettmar PW, Pearson JP. Rheological studies of breakdown and reformation of gastric mucus gel demonstrates its unique flow properties which are essential to the maintenance of an intact protective barrier .
In: British Society of Gastroenterology Annual Meeting . 2001, Glasgow, UK: BMJ Group.
Strugala V, Hainsworth PJ, Bennett MK, Hudson M, Dettmar PW, Allen A, Pearson JP. Thickness and continuity of the human colonic mucus layer is decreased in active UC but remains normal in quiescent UC .
In: British Society of Gastroenterology Annual Meeting . 2001, Glasgow, UK: BMJ Group.
Smirnova MG, Kiselev SL, Birchall JP, Pearson JP. Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-6 .
European Cytokine Network 2001, 12 (1), 119-125.
Sunderland AM, Dettmar PW, Pearson JP. Alginates inhibit pepsin activity in vitro; A justification for their use in gastro-oesophageal reflux disease (gord) .
Gastroenterology 2000, 118 (4), A21-A21.
Keegan SJ, Hormaeche CE, Pearson JP, Gally DL. Characterisation and adherence mechanisms of Escherichia coli strains causing infections in patients with a reconstructed bladder .
Advances in Experimental Medicine and Biology 2000, 485 (III), 263-271.
Strugala V, Allen A, Havler ME, Dettmar PW, Pearson JP. Deprivation of non-starch polysaccharides in the rat diet causes mucosal damage .
In: Digestive Disease Week and the 101st Annual Meeting of the American Gastroenterological Association . 2000, San Diego, USA: American Gastroenterology Association.
Peizhong L, Whatmough K, Birchall JP, Wilson JA, Pearson JP. Does the bacterial DNA found in middle ear effusions come from viable bacteria? .
Clinical Otolaryngology and Allied Sciences 2000, 25 (6), 570-576.
Taylor C, Allen A, Dettmar PW, Pearson JP. Evidence for two discrete mucus secretions in the normal stomach .
In: GASTROENTEROLOGY . 2000.
N'Dow, J., Pearson, J. P., Bennett, M. K., Neal, D. E., Robson, C. N. Mucin gene expression in human urothelium and in intestinal segments transposed into the urinary tract .
Journal of Urology 2000, 164 (4), 1398-1404.
Strugala V, Pearson JP, Dettmar PW, Havler ME, Allen A. Mucosal bleeding in the rat colon occurs when non-starch polysaccharide is absent from the diet .
In: GUT . 2000.
Severn TL, Hutton DA, Birchall JP, Pearson JP. Preliminary studies on mucin gene expression by human middle ear mucosa .
Edited by Bara, J.; Christen, Y.; Droy-Lefaix, M.T. in Digestive mucus from research to clinical implications published by Irvin editions 119-123 2000.
Hutton DA, Allen A, Pearson JP. Proteinase Activity .
In: Corfield, A.P, ed. Glycoprotein Methods and Protocols: The Mucins . Humana Press Inc, 2000, pp.393-401.
Knight J, Pearson JP, Droy-Lefaix MT, Allen A. Quenching of free radicals by mucus secretions .
In: Bara, J; Christen, Y; Droy-Lefaix, MT, ed. Digestive mucus, from research to clinical implications . Irvin editions, 2000, pp.65-67.
Pearson JP, Allen A, Hutton DA. Rheology of Mucin .
In: Corfield, A.P, ed. Glycoprotein Methods and Protocols: The Mucins . Humana Press Inc, 2000, pp.99-109.
Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: A review .
Clinical Otolaryngology and Allied Sciences 2000, 25 (3), 181-194.
Fergie N, Guo L, Pearson JP, Birchall JP. The influence of prednisolone on the secretion of MUC5AC from TH29-MTX cell culture .
Clinical Otolaryngology and Allied Sciences 2000, 25 (6), 570-576.
Smirnova MG, Birchall JP, Pearson JP. TNF-alpha in the regulation of MUC5AC secretion: Some aspects of cytokine-induced mucin hypersecretion on the in vitro model .
Cytokine 2000, 12 (11), 1732-1736.
Strugala V, Dettmar PW, Pearson JP, Allen A. Two forms of the colonic mucus barrier .
Edited by Bara, J; Christen, Y; Droy-Lefaiz, M.T. in Digestive mucus from research to clinical implications published by Irvin editions 143-147 2000.
Hutton D.A., Fogg F.J.J., Kubba H., Birchall J.P. and Pearson J.P. Heterogeneity in the protein cores of mucins isolated from human middle ear effusions: evidence for the expression of different mucin gene products .
Glycoconjugate Journal 1998, 15 , 283-291.
N'Dow J, Pearson JP, Bennett M, Robson CN, Neal DE. Mucin gene expression in ileal segments transposed to the urinary tract .
In: XIIth Congress of the European Association of Urology . 1998, Paris: Karger.
N'Dow JM, Pearson JP, Bennett M, Neal DE, Robson CN. Mucin gene expression in normal bladder and expression of MUC2 in TCC of the bladder .
British Journal of Urology 1998, 81 (4), 24-.
N'Dow JM, Pearson JP, Neal DE, Robson CN. Does normal urine contain mucin? .
British Journal of Urology 1997, 80 (1), 161-162.
N'Dow, J., Pearson, J. P., Sunderland, A. M., Neal, D. E., Robson, C. N. The protective layer of the bladder: Is it mucin? .
British Journal of Urology 1997, 80 (Supplement 2), 7.
