Newcastle University

Introduction

Jeremy Parr is a Paediatric Neurodisability clinical academic with wide ranging research interests in the Neurodisability field, including investigating the neurobiological basis of disabilities, carrying out intervention studies to ameliorate disability, and undertaking research into clinical service delivery.

Phenotypic and genetic aspects of autism spectrum disorders are main research themes. Jeremy is a member of the International Molecular Genetic Study of Autism Consortium and the Autism Genome Project, sits on the scientific advisory board of two UK Neurodisability research charities, and is an executive committee member of the British Academy of Childhood Disability.

Previous Positions

Nov 2006 – May 2009 Consultant and Honorary Senior Lecturer, Paediatric Neurodisability, Great Ormond Street Hospital and the Institute of Child Health, London

Sept 2008 – May 2009 Senior Academic Research Fellow and Honorary Consultant Paediatrician University of Oxford and Oxford Children’s Hospital

Funding

A British Paediatric Neurology Surveillance Unit UK study of childhood myasthenia Principal Investigator: £34 500 from the Myasthenia Gravis Association

The effect of optimising nutrition on growth and neurodisability in children at risk of cerebral palsy
Co Principal Investigator (with Peter Sullivan): £163 000 from the Castang Foundation

The effect of optimising nutrition on growth and neurodisability in young children with confirmed cerebral palsy
Co Principal Investigator (with Peter Sullivan): £183 000 from SPARKS

Measuring the efficacy of computer communication intervention for children with cerebral palsy Co Principal Investigator: BACD / RCPCH Paul Polani Award £7 500

Wellcome Trust Value in People Award, £38 000: The University of Oxford, 2008-09

• Palmer E, Ketteridge C, Parr J, Baird G, LeCouteur A. ASD diagnostic assessments: Improvements since NAP-C publication. Archives A Disease of Childhood 2011, 96, 473-475.
• Palmer E, Ketteridge C, Parr JR, Baird G, LeCouteur A. Autism spectrum disorder diagnostic assessments: improvements since publication of the National Autism Plan for Children. Archives of Disease in Childhood 2011, 96(5), 473-475.
• Parr J, Wittemeyer K, LeCouteur A. Commentary: The Broader Autism Phenotype Implications for Research & Clinical Practice. In: Amaral, D., Geschwind, D., Dawson, G, ed. Autism Spectrum Disorders. New York, USA: Oxford University Press, 2011, pp.521-524.
• Absoud M, Parr JR, Salt A, Dale N. Developing a schedule to identify social communication difficulties and autism spectrum disorder in young children with visual impairment. Developmental Medicine and Child Neurology 2011, 53(3), 285-288.
• Anney RJ, Kenny EM, ODushlaine C, Yaspan BL, Parkhomenka E, Buxbaum JD, Sutcliffe J, Gill M, Gallagher L, Bailey AJ, Fernandez BA, Szatmari P, Scherer SW, Patterson A, Marshall CR, Pinto D, Vincent JB, Fombonne E, Betancur C, Delorme R, Leboyer M, Bourgeron T, Mantoulan C, Roge B, Tauber M, Freitag CM, Poustka F, Duketis E, Klauck SM, Poustka A, Papanikolaou K, Tsiantis J, Gallagher L, Gill M, Anney R, Bolshakova N, Brennan S, Hughes G, McGrath J, Merikangas A, Ennis S, Green A, Casey JP, Conroy JM, Regan R, Shah N, Maestrini E, Bacchelli E, Minopoli F, Stoppioni V, Battaglia A, Igliozzi R, Parrini B, Tancredi R, Oliveira G, Almeida J, Duque F, Vicente A, Correia C, Magalhaes TR, Gillberg C, Nygren G, Jonge MD, VanEngeland H, Vorstman JA, Wittemeyer K, Baird G, Bolton PF, Rutter ML, Green J, Lamb JA, Pickles A, Parr JR, Couteur AL, Berney T, McConachie H, Wallace S, Coutanche M, Foley S, White K, Monaco AP, Holt R, Farrar P, Pagnamenta AT, Mirza GK, Ragoussis J, Sousa I, Sykes N, Wing K, Hallmayer J, Cantor RM, Nelson SF, Geschwind DH, Abrahams BS, Volkmar F, PericakVance MA, Cuccaro ML, Gilbert J, Cook EH, Guter SJ, Jacob S, Nurnberger JI, McDougle CJ, Posey DJ, Lord C, Corsello C, Hus V, Buxbaum JD, Kolevzon A, Soorya L, Parkhomenko E, Leventhal BL, Dawson G, Vieland VJ, Hakonarson H, Glessner JT, Kim C, Wang K, Schellenberg GD, Devlin B, Klei L, Minshew N, Sutcliffe JS, Haines JL, Lund SC, Thomson S, Yaspan BL, Coon H, Miller J, McMahon WM, Munson J, Estes A, Wijsman EM. Gene-ontology enrichment analysis in two independent family-based samples highlights biologically palusible processes for autism spectrum disorder. European Journal of Human Genetics 2011, 19(10), 1082-1089.
• Parr JR, Buswell CA, Banerjee K, Fairhurst C, Williams J, OHare A, Pennington L. Management of drooling in children: a survey of UK paediatricians' clinical practice. Child: Care, Health and Development 2011, (epub ahead of print).
• Watson R, Parr J, Joyce C, May C, LeCouteur A. Models of transitional care for young people with complex health needs: a scoping review. Child: Care, Health and Development 2011, 37(6), 780-791.
• Vieland VJ, Hallmayer J, Huang Y, Pagnamenta AT, Pinto D, Khan H, Monaco AP, Paterson AD, Scherer SW, Sutcliffe JS, Szatmari P, Parr JR. Novel method for combined likage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism. Journal of Neurodevelopmental Disorders 2011, 3(2), 113-123.
• Gray L, Ansell P, Baird G, Parr JR. The continuing challenge of diagnosing autism spectrum disorder in children with Down syndrome. Child: Care, Health and Development 2011, 37(4), 459-461.
• Parr J, Le Couteur A. What is the Broader Autism Phenotype?. In: Bolte, S., Hallmayer, J, ed. Autism Spectrum Conditions: FAQs on Autism, Asperger Syndrome, and Atypical Autism Answered by International Experts. Cambridge, Massachusetts, USA: Hogrefe Publishing, 2011, pp.521-524.
• Pagnamenta AT, Bacchelli E, de Jonge MV, Mirza G, Scerri TS, Minopoli F, Chiocchetti A, Ludwig KU, Hoffmann P, Paracchini S, Lowy E, Harold DH, Chapman JA, Klauck SM, Poustka F, Houben RH, Staal WG, Ophoff RA, O'Donovan MC, Williams J, Northen MM, Schulte Korne G, Deloukas P, Ragoussis J, Bailey AJ, Maestrini E, Monaco AP, International Molecular Genetic Study Of Autism Consortium. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biological Psychiatry 2010, 68(4), 320-328.
• Noor A, Whibley A, Marshall CR, Gianakopoulos PJ, Piton A, Carson AR, Orlic Milacic M, Lionel AC, Sato D, Pinto D, Drmic I, Noakes C, Senman L, Zhang X, Mo R, Gauthier J, Crosbie J, Pagnamenta AT, Munson J, Estes AM, Fiebig A, Franke A, Schreiber S, Stewart AF, Roberts R, McPherson R, Guter SJ, Cook EH, Dawson G, Schellenberg GD, Battaglia A, Maestrini E, Jeng L, Hutchison T, RajcanSeparovic E, Chudley AE, Lewis SM, Liu X, HOlden JJ, Fernandez B, Zwaigenbaum L, Bryson SE, Roberts W, Szatmari P, Gallagher L, Stratton MR, Gecz J, Brady AF, Schwartz CE, Schachar RJ, Monaco AP, Rouleau GA, Hui CC, Lucy RF, Scherer SW, Vincent JB, Autism Genome Project Consortium. Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. Science Translational Medicine 2010, 2(49), 68.
• Parr J, Le Couteur A, Baird G, Rutter M, Pickles A, Fombonne E, Bailey A, The International Molecular Genetic Study of Autism Consortium (IMGSAC). Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample. Journal of Autism and Developmental Disorders 2010, 41(3), 332-340.
• Wallace S, Sebastian C, Pellicano E, Parr J, Bailey A. Face Processing Abilities in Relatives of Individuals With ASD. Autism Research 2010, 3(6), 345-349.
• Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Berney T, Le Couteur A, McConachie H, Parr JR. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 2010, 466, 368–372.
• Maestrini E, Pagnamenta AT, Lamb JA, Bacchelli E, Sykes NH, Sousa I, Toma C, Barnby G, Butler H, Winchester L, Scerri TS, Minopoli F, Reichert J, Cai G, Buxbaum JD, Korvatska O, Schellenberg GD, Dawson G, deBildt A, Minderaa RB, Mulder EJ, Morris AP, Bailey AJ, Monaco AP, IMGSAC. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Molecular Psychiatry 2010, 15(9), 954-968.
• Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder E, Kantojarvi K, Jarvela I, Klauck SM, Poustka F, Bailey AJ, Monaco AP, The International Molecular Genetic Study of Autism Consortium, Newcastle Site: Le Couteur, A. Principal Investigator. Linkage and Candidate Gene Studies of Autism Spectrum Disorders in European Populations. European Journal of Human Genetics 2010, 18(9), 1013-1019.
• Sousa I, Clark TG, Holt R, Pagnamenta AT, Mulder EJ, Minderaa RB, Bailey AJ, Battaglia A, Klauck SM, Poustka F, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). Polymophisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. Molecular Autism 2010, 1(1), 7.
• Parr JR, Dale NJ, Shaffer LM, Salt AT. Social communication difficulties and autism spectrum disorder in young children with optic nerve hypoplasia and/or septo-optic dysplasia. Developmental Medicine and Child Neurology 2010, 52(10), 917-921.
• Pagnamenta AT, Wing K, Sadighi AE, Knight SJ, Bolte S, Schmotzer G, Duketis E, Poustka F, Klauck SM, Poustka A, Ragoussis J, Bailey AJ, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). A 15q13.3 microdeletion segregating with autism. European Journal of Human Genetics 2009, 17(5), 687-692.
• Absoud M, Parr J, Pretorius P, Zaiwalla Z, Jayawant S. A novel ARX phenotype: Rapid neurodegeneration with Ohtahara Syndrome and a dyskinetic movement disorder. Developmental Medicine and Child Neurology 2009, 52(3), 305-307.
• Sykes NH, Toma C, Wilson N, Volpi EV, Sousa I, Pagnamenta AT, Tancredi R, Battaglia A, Maestrini E, Bailey AJ, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection. European Journal of Human Genetics 2009, 17, 1347-1353.
• Weiss LA, Arking DE, McConachie H. Letter: A genome-wide linkage and association scan reveals novel loci for autism. Nature 2009, 461, 802-808.
• Sousa I, Clark TG, Kobayashi K, Choma M, Holt R, Sykes NH, Lamb JA, Bailey AJ, Battaglia A, Maestrini E, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). MET and autism susceptibility: family and case-control studies. European Journal of Human Genetics 2009, 17(6), 749-758.
• Gong X, Bacchelli E, Blasi F, Toma C, Betancur C, Chaste P, Delorme R, Durand CM, Fauchereau F, Botros HG, Leboyer M, Mouren-Simeoni M-C, Nygren G, Anckarsäter H, Rastam M, Gillberg IC, Gillberg C, Moreno-De-Luca D, Carone S, Nummela I, Rossi M, Battaglia A, The International Molecular Genetic Study of Autism Consortium (IMGSAC), Jarvela I, Maestrini E, Bourgeron T. Analysis of X chromosome inactivation in autism spectrum disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2008, 147B(6), 830-835.
• Liu XQ, Paterson AD, Szatmaric P, Autism Genome Project Consortium. Genome-wide linkage analyses of quantitative and categorical autism subphenotypes. Biological Psychiatry 2008, 64(7), 561-570.
• Lang TF, Parr JR, Matthews EE, Gray RG, Bonham JR, Kay JD. Practical difficulties in the diagnosis of transient non-ketotic hyperglycinaemia. Developmental Medicine and Child Neurology 2008, 50(2), 175-179.
• Parr JR, Pang K, Mollett A, Zaiwalla Z, Selway R, McCormick D, Jayawant S. Epilepsy responds to vagus nerve stimulation in ring chromosome 20 syndrome. Developmental Medicine and Child Neurology 2006, 48(1), 80.
• Lamb JA, Barnby G, Bonora E, Sykes N, Bacchelli E, Blasi F, Maestrini E, Broxholme J, Tzenova J, Weeks D, Bailey AJ, Monaco AP, International Molecular Genetic Study of Autism Consortium. Analysis of the IMGSAC autism susceptibility loci: evidence for sex-limited and parent-of-origin specific effects. Journal of Medical Genetics 2005, 42, 132-137.
• Barnby G, Abbott A, Sykes N, Morris A, Weeks DE, Lamb J, Bailey AJ, Monaco AP, International Molecular Genetics Study of Autism Consortium (IMGSAC). Candidate-Gene Screening and Association Analysis at the Autism-Susceptibility Locus on Chromosome 16p: Evidence of Association at GRIN2A and ABAT. Journal of Human Genetics 2005, 76(6), 950-966.
• Beyer KS, Blasi F, Bacchelli E, Klauck SM, Maestrini E, Poustka A, International Molecular Genetic Study of Autism Consortium (IMGSAC). Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Human Genetics 2002, 111(4-5), 305-309.
• Parr J, Baird G, Le Couteur A, Rutter M, Bailey A, IMGSAC. Phenotypic characteristics of autistic regression in an international multiplex sample. In: American Journal of Medical Genetics: 10th World Congress of Psychiatric Genetics. 2002, Brussels, Belgium: John Wiley & Sons, Inc.