Professor James Shaw
Professor of Regenerative Medicine for Diabetes

Roles and Responsibilities

Glaxo-Wellcome Senior Fellow in Diabetes University of Newcastle
Honorary Consultant Physician, Newcastle upon Tyne Acute Hospitals Trust and Newcastle Primary Care Trust

Qualifications

1986 BSc Medical Science; St Andrews University
1987 BSc (Honours 2.1) Biochemistry; St Andrews University
1990 MB ChB (Honours Surgery); Manchester Medical School
1993 MRCP (UK)
2000 PhD; University of Aberdeen

Previous Positions

1.8.90-31.1.91Pre-Registration House Surgeon; Victoria Hospital Kirkcaldy
1.2.91-31.7.91Pre-Registration House Physician; Manchester Royal Infirmary
1.8.91-31.7.93 Senior House Officer Medical Rotation; Stobhill Hospital Glasgow
1.8.93-31.1.94 SHO3 Medicine / Clinical Pharmacology; Woodend Hospital Aberdeen
1.2.94-31.7.96 Career Registrar Diabetes / Endocrinology; Aberdeen Royal Infirmary
1.8.96-31.7.99 MRC Clinical Training Fellow; University of Aberdeen
1.8.99-31.1.00 Specialist Registrar Diabetes / Endocrinology; Aberdeen Royal Infirmary
1.2.00-31.7.00 Clinical Lecturer Diabetes / Endocrinology; University of Aberdeen
1.8.00-17.5.01 Glaxo-Wellcome Senior Fellow; University of Aberdeen
18.5.01-present Glaxo-Wellcome Senior Fellow Honorary Consultant Physician; University of Newcastle

Memberships

1991 British Medical Association
1994 Society for Endocrinology
1995 Caledonian Society for Endocrinology
1995 Diabetes (UK)
1997 Collegiate Member of the Royal College of Physicians of
Edinburgh
1998 European Association for the Study of Diabetes

Research Interests

Major interests in the development of gene therapy and beta cell replacement for diabetes including stem cell approaches; pancreatic/islet transplantation; and pump therapy by continuous subcutaneous insulin infusion.

More information on the The Institute of Stem Cell Biology and Regenerative Medicine website.

Previous awards:
1990 WG Campbell Final Year Surgery Prize; Manchester Medical School
1994 Clinical Endocrinology Trust Prize; RSM Endocrinology Section
1997 Poster Prize; MRC New Generation Meeting
1997 Sir James Black Young Investigator Award; Scottish Society for Experimental Medicine
1998 Life Technologies Poster Award; Association of Clinical Biochemists
1998 Fitzgerald-Peel Prize; Scottish Society of Physicians
1998 Cuthbertson Award; Rowett Research Institute

Current Work

Senior Lecturer in Diabetes University of Newcastle. Honorary Consultant Physician, Newcastle upon Tyne Acute Hospitals Trust and Newcastle Primary Care Trust

Research Roles

Committed to career as clinical academic from the outset, undertaking 3 years pre-clinical training towards BSc and a further intercalated honours degree in Biochemistry prior to 3 years clinical training leading to MB ChB.

As a specialist clinical trainee in diabetes and endocrinology, I attained an MRC Clinical Training Fellowship and undertook a PhD in Molecular Endocrinology in the field of gene therapy and beta cell replacement for diabetes with Prof Kevin Docherty.

Having completed specialist training, I attained a prestigious 6 year GlaxoSmithKline Senior Clinical Fellowship enabling me to establsih my basic research group and translational research programme in Newcastle.

Having accrued preliminary data, as chair of the UK Islet Transplant Consortium, I led the successful bid for NHS funding of clinical islet transplantation in the UK as a sustainable hub-and-spoke programme.

I am PI on a Diabetes UK-funded grant enabling a detailed experimental approach to detrerimne biomedical and psychosocial outcomes of islet transplantation.

I am PI on a REgeNer8 funded grant to further optimise islet quality assurance and transport with the specific goal of developing in vitro predictors of graft function and immunogenicty correlating with clinical outcomes.

I am PI on an investigator-led multicentre RCT to determine optimised conventional management for those with type 1 diabetes complicated by recurent severe hypoglycaemia.

I was promoted to a personal chair at Newcastle University last year. I am clinical lead for the International Centre for Life Cell Transplant GMP Facility and chair the North East Stem Cell Institute Clinical Translational Group.

I am co-editor with Prof James Shapiro, University of Alberta of the textbook 'Islet transplantation and beta-cell replacement therapy for diabetes'.

Funding

01.02.10-31.01.11 RegeNer8 Translational Regenerative Medicine Award (£299,968)
A sustainable quality-assured system for assessment of pancreatic islets for product release and transport to geographically distant clinical transplant centres (3 hours per week)

01.01.01.10 -31.12.10 Newcastle Healthcare Charity (Collin M, Hambleton S, Dickinson AM, van Laar J, Shaw JAM) Implementation of mesenchymal stromal cell therapy in Newcastle (1 hour per week)

01.10.09-30.09.12 Diabetes UK PhD Studentship (£83,470)
Isolation, characterisation and beta-cell differentiation potential of pluripotent stem cells derived from adult human pancreas (2 hours per week)

01.06.09 Diabetes UK Equipment grant (Arden C; Shaw J; Aldibbiat A £45,000)
Live-cell imaging of protein interactions and lineage tracing of human pancreatic cells

01.05.09-30.04.12 Tolerx Defend1 RCT: anti-CD3 in newly diagnosed Type 1 diabetes (Leech N, Shaw J, Walker M) 1 hour per week

01.10.08-31.07.12 Diabetes UK (£1,401,716)
Prevention of recurrent severe hypoglycaemia: a definitive RCT comparing optimised MDI and CSII with or without adjunctive real-time continuous glucose monitoring (4 hours per week)

01.04.08-31.03.11 Diabetes UK project grant (Walker M, Chinnery P, Shaw J £155,359 )
Does decreased mitochondrial DNA copy number with ageing impair pancreatic beta-cell function?

01.03.08 Medtronic (Shaw local PI budget to be confirmed)
Evaluation of first clinically available pump with ‘closed loop’ capability

01.01.08-31.12.13 Diabetes UK (Agius L, Arden C, Shaw J £29,239)
Equipment for insulin determination by HTRF

01.12.07-31.05.08 North East Stem Cell Institute (£8,000)
Phenotypic characterisation of stem cell derived beta-cells prior to clinical translation

01.10.07-30.09.12 Sanofi-Aventis (Shaw local PI £15,000)
Cardiovascular Risk Evaluation in people with type 2 Diabetes on Insulin Therapy. Long-term international non- interventional study in people with Type 2 diabetes treated with insulin. (1 hour per week)

01.07.07-31.01.12 Diabetes UK project grant (£430,255)
Establishment of optimised biomedical and psychosocial measures to determine overall outcomes in islet transplant recipients (2 hours per week)

01.01.07 -30.06.07 Diabetes Research and Wellness Foundation project grant (£29,940)
Enhancement of â-cell mass and function in human islets by physiological factors upregulated in pregnancy

01.01.07-31.12.07 Diabetes Foundation project grant (Amiel SA; Shaw JAM £160,000)
A proposal to validate and establish remote islet isolation for the treatment of Type 1 diabetes in the UK

1.8.00-31.7.06 Glaxo-Wellcome Senior Fellowship: (£350,000)
Transplantation and gene therapy for diabetes

01.06.05-31.05.06 Newcastle upon Tyne Hospitals NHS Charity research grant (£38,423)
Remote islet transplantation: a feasibility study

01.04.05 One North East stem cell equipment grant (£27,000)

01.01.05-31.12.06 Blood glucose awareness training in Type 1 diabetes
Principal investigator initiated (supported by Novo Nordisk £25,000)

01.10.04-30.09.05 Diabetes UK Project Grant (Agius L; Shaw J £45,056)
Cellular analysis of glucokinase MODY mutants in pancreatic beta-cells and hepatocytes

1.6.02-30.9.04 Project grant supported by Aventis / MiniMed (£160,000)
Can hypoglycaemia awareness be restored in individuals with established Type 1 diabetes mellitus and severe hypoglycaemia by detection and targeted prevention of hypoglycaemia employing an optimised subcutaneous insulin regime employing insulin Glargine

1.11.01-31.10.02 Freeman Hospital Trustees Grant (£37567):
Development of glucose-responsive insulin secretion in transfected human myoblasts

1.11.01 Joint Research Equipment Initiative (MRC) grant (Agius L / Shaw JAM £27329)