Professor John DarkProfessor of Cardiothoracic Surgery
Email: john.dark@ncl.ac.uk Telephone: +44 (0) 191 223 1450 Fax: +44 (0) 191 233 1152 Address: Regional Cardiothoracic Centre
S. C. Clark, C. Sudarshan, R. Khanna, J. Roughan, P. A. Flecknell and J. H. Dark. Controlled reperfusion and pentoxifylline modulate reperfusion injury after single lung transplantation .
Journal of Thoracic and Cardiovascular Surgery 1998, 115 , 1335-1341.
J. H. Dark. Priorities for lung transplantation .
Lancet 1998, 351 , 4-5.
A. R. Gennery, A. J. Cant, G. P. Spickett, D. Walshaw, S. Hunter, A. Hasan, J. R. L. Hamilton and J. Dark. Effect of immunosuppression after cardiac transplantation in early childhood on antibody response to polysaccharide antigen .
Lancet 1998, 351 , 1778-1781.
Warrens AN, Birch R, Collett D, Daraktchiev M, Dark JH, Galea G, Gronow K, Neuberger J, Hilton D, Whittle IR, Watson CJE, Advisory Comm Safety Blood Tissues. Advising Potential Recipients on the Use of Organs From Donors With Primary Central Nervous System Tumors .
Transplantation 2012, 93 (4), 348–353.
Robertson AGN, Krishnan A, Ward C, Pearson JP, Small T, Corris PA, Dark JH, Karat D, Shenfine J, Griffin SM. Anti-reflux surgery in lung transplant recipients: outcomes and effects on quality of life .
The European Respiratory Journal 2012, 39 (3), 691-697.
Bonser RS, Taylor R, Collett D, Thomas HL, Dark JH, Neuberger J, Cardiothoracic Advisory Grp NHS, Assoc Lung Transplant Phys UK. Effect of donor smoking on survival after lung transplantation: a cohort study of a prospective registry .
Lancet 2012, 380 (9843), 747-755.
Watson CJE, Dark JH. Organ transplantation: historical perspective and current practice .
British Journal of Anaesthesia 2012, 108 (s1), i29-i42.
Saleki M, Ali S, Dark JH, Kirby J. Strategies for inhibition of chemokine (CCL2) mediated monocyte migration in lethal reperfusion injury .
In: Annual Meeting of the Society of Academic and Research Surgery . 2012, Nottingham, UK: John Wiley & Sons Ltd.
Dark JH, Karamanou D, Clark S, Mahesh P, Watson B, Corris PA, Fisher AJ. Successful Transplantation of Unusable Donor Lungs Using Ex-Vivo Lung Perfusion: The Newcastle Experience .
In: 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation . 2012, Prague, Czech Republic: Elsevier Inc.
Bonser RS, Taylor R, Collett D, Thomas HL, Dark JH, Neuberger J. The Smoking Donor - Benefit or Hazard to the Potential Lung Transplant Recipient? .
In: 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation . 2012, Prague, Czech Republic: Elsevier Inc.
Khurram MA, Mownah OA, Ray C, Kanwar A, Carter NM, Brassil J, Rees D, Stamp S, Dark JH, Talbot D. An ex vivo model for reanimating porcine hearts sourced from donors after cardiac death .
In: Transplant International: 15th Congress of the ESOT and 22nd Annual Conference of the BSHI . 2011, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
Stansby G, Macdonal S, Allison R, de Belder M, Brown MM, Dark J, Featherstone R, Flather M, Ford GA, Halliday A, Malik I, Naylor R, Pepper J, Rothwell PM. Asymptomatic carotid disease and cardiac surgery consensus .
Angiology 2011, Online ahead of print.
Cronin AJ, Rose ML, Dark JH, Douglas JF. British transplant research endangered by the Human Tissue Act .
Journal of Medical Ethics 2011, 37 (8), 512-514.
Loberg AG, Stallard J, Dunning J, Dark J. Can leucocyte depletion reduce reperfusion injury following cardiopulmonary bypass? .
Interactive Cardiovascular and Thoracic Surgery 2011, 12 (2), 232-237.
Khurram MA, Mownah OA, Ray C, Kanwar A, Carter NM, Rees D, Brassil J, Stamp S, Dark JH, Talbot D. Donation after cardiac death: Can hearts be sucessfully reanimated? .
In: Transplant International: 15th Congress of the ESOT and 22nd Annual Conference of the BSHI . 2011, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
Dark JH, Forsythe JLR, Tedder RS. HIV and Organ Donation [authors' reply] .
Transplantation 2011, 91 (4), E23-E24.
Mownah OA, Khurram MA, Ray C, Majo J, Carter NM, Brassil J, Peaston R, Phillipson K, Stamp S, Dark JH, Talbot D. Preservation of donation after cardiac death hearts using oxygenated, hypothermic machine perfusion .
In: Transplant International: 15th Congress of the ESOT and 22nd Annual Conference of the BSHI . 2011, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
Walden HR, Vallance AE, Knights DPH, Karamanou DM, Fox CR, Rostron AJ, Simpson J, Kirby JA, Dark JH, Fisher A. The Alarmin HMGB1 Is an Inflammatory Mediator in Brain Death Induced Lung Damage .
In: Journal of Heart and Lung Transplantation: 31st Annual Meeting and Scientific Sessions on International Society for Heart and Lung Transplantation . 2011, San Diego, California, USA: Elsevier Inc.
Mownah OA, Khurram MA, Ray C, Carter NM, Peaston R, Phillipson K, Gibbs K, Gardener K, Stamp S, Dark JH, Talbot D. Using dialysis for prolonged ex vivo warm reperfusion of DCD hearts .
In: Transplant International: 15th Congress of the ESOT and 22nd Annual Conference of the BSHI . 2011, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
Botha P, Archer L, Anderson RL, Lordan J, Dark JH, Corris PA, Gould FK, Fisher A. Colonization of lung transplant recipients with Pseudomonas Aeruginosa and the development of bronchiolitis obliterans syndrome .
The Journal of Heart and Lung Transplantation 2006, 25 (2), S82.
Avlonitis VS, Kirby JA, Dark JH. Donor treatment with nitric oxide does not improve reperfusion injury after transplantation of lungs damaged by brain death .
The Journal of Heart and Lung Transplantation 2006, 25 (2), S64.
Avlonitis VS, Rostron AJ, Kirby JA, Dark JH. The donor lung improves with time and aprotinin treatment after brain death .
In: Journal of Heart and Lung Transplantation: 26th Annual Meeting and Scientific Sessions International Society for Heart and Lung Transplantation . 2006, Madrid, Spain: Elsevier Inc.
Botha P, Archer L, Anderson RL, Lordan J, Dark JH, Corris PA, Gould FK, Fisher A. The role of primary graft dysfunction or recurrent acute rejection episodes in the development of Pseudomonas colonisation after lung transplantation .
In: Journal of Heart and Lung Transplantation: 26th Annual Meeting and Scientific Sessions International Society for Heart and Lung Transplantation . 2006, Madrid, Spain: Elsevier Inc.
Avlonitis VS, Kirby JA, Dark JH. Early hemodynamic lung injury during donor brain death enhances reperfusion injury after lung transplantation .
In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation . 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
Forrest IA, Murphy DM, Lordan JL, Pritchard G, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Ward C, Corris PA. Epithelial to mesenchymal transition in clinically stable lung transplant recipients .
In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation . 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
Forrest IA, Nicholson L, Platt R, Ward C, Dark JH, Middleton PG, Corris PA. Genetic polymorphisms and bronchiolitis obliterans syndrome post lung transplantation .
In: Journal of Heart and Lung Transplantation: The International Society for Heart and Lung Transplantation Twenty-Fifth Anniversary Meeting and Scientific Sessions . 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
Forrest IA, Krause A, Corris PA, Dark JH, Gould FK. Negative association between CMV-viraemia and bronchiolitis obliterans syndrome in lung transplant recipients .
In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation . 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
Avlonitis VS, Kirby JA, Dark JH. The effect of time from donor brain death to retrieval on reperfusion injury after lung transplantation .
In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation . 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
Ward C, Headland L, Vest S, Brownlee IA, Forrest IA, Ward TA, Pritchard G, Murphy DM, Pearson JP, Dark J, Corris P. Clinically silent gastric aspiration is common in lung allografts .
In: Winter Meeting of the British Thoracic Society . 2004, London: Thorax: BMJ Publishing Group.
Forrest IA, Murphy D, Lordan JL, Pritchard GE, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Corris PA, Ward C. Epithelial to mesenchymal transition in clinically stable lung transplantation .
In: Winter Meeting of the British Thoracic Society . 2004, London: Thorax: BMJ Publishing Group.
Fisher AJ, Donnelly SC, Pritchard G, Dark JH, Corris PA. Objective evaluation of selection criteria to assess donor lung suitability show poor discrimination of infection or inflammation .
Thorax 2004, 59 (5), 434-438.
Brownlee IA, Ward C, Forrest I, Pritchard G, Murphy D, Dark J, Corris PA, Pearson JP. Pepsin detection in the lungs of transplant patients: Evidence of gastric refluxate .
In: 105th Annual Meeting of the American Gastroenterological Association . 2004, New Orleans, LA, USA: W.B. Saunders Co.
Parry G, Hofmann B, Dark JH. Early efficacy and late outcome of percutaneous transluminal coronary angioplasty (PTCA) in cardiac transplant recipients .
In: Heart: Annual Scientific Conference of the British Cardiac Society . 2003, Glasgow, UK: BMJ Group.
Rutherford RM, Fisher AJ, Dark JH, Forty J, Hilton C, Hasan A, Corris PA. Functional status of 10 year survivors after lung transplantation .
In: Thorax: Winter Meeting of the British Thoracic Society . 2003, London, UK: BMJ Group.
de Soyza A, Dark JH, Corris PA. Outcomes of 92 adult CF patients referred to a UK transplant centre; Single centre prognostic modelling .
In: Thorax: Winter Meeting of the British Thoracic Society . 2003, London, UK: BMJ Group.
Aziz TM, Pillary TM, Corris PA, Forty J, Hilton CJ, Hasan A, Dark JH. Perfadex for clinic lung procurement: is it an advance? .
Annals of Thoracic Surgery 2003, 75 (3), 990-995.
De Soyza A, Archer L, Wardle J, Parry G, Dark JH, Gould K, Corris PA. Pulmonary transplantation for cystic fibrosis: Pre-transplant recipient characteristics in patients dying of peri-operative sepsis .
Journal of Heart and Lung Transplantation 2003, 22 (7), 764-769.
Wigfield CH, Golledge HDR, Shenton BK, Kirby JA, Dark JH. Ameliorated reperfusion injury in lung transplantation after reduction of brain death induced inflammatory graft damage in the donor .
Journal of Heart and Lung Transplantation 2002, 21 (1), 57.
Curtis HJ, Bourke SJ, Corris PA, Dark JH. Lung transplantation outcome in cystic fibrosis patients with previous pleural procedures .
In: Thorax: Winter Meeting of the British Thoracic Society . 2002, London: BMJ Group.
De Soyza A, Gould K, Parry G, Dark JH, Corris PA. Sequential single lung transplantation for septic lung disease; A single centre comparison between CF and non-CF bronchiectasis .
In: Thorax: Winter Meeting of the British Thoracic Society . 2002, London: BMJ Group.
Gok MA, Shenton BK, Peaston R, Cornell C, Gicquel HJ, Aitchison D, Mantle D, Dark J, Talbot D. Use of streptokinase in a non-heart-beating donor animal model .
In: Transplantation Proceedings: 2nd International Congress on Immunosuppression . 2002, San Diego, California, USA: Elsevier Inc.
Langley P, Dark JH, Murray A. Variability of body surface impedance measurements in cardiac transplant patients and normal subjects .
In: Computers in Cardiology . 2002, Memphis, Tennesee, USA: IEEE.
Clark SC, Sudarshan CD, Dark JH. Controlled perfusion of the transplanted lung .
Annals of Thoracic Surgery 2001, 71 (5), 1755-1756.
De Soyza AG, Dark JH, Parums DV, Curtis A, Corris PA. Donor acquired small cell lung cancer following pulmonary transplantation .
Chest 2001, 120 (3), 1030-1031.
Fisher AJ, Donnelly SC, Hirani N, Haslett C, Strieter RM, Dark JH, Corris PA. Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation .
American Journal of Respiratory and Critical Care Medicine 2001, 163 (1), 259-265.
Aitchison JD, Orr HE, Flecknell PA, Kirby JA, Dark JH. Functional assessment of non-heart-beating donor lungs: Prediction of post-transplant function .
European Journal of Cardio-thoracic Surgery 2001, 20 (1), 187-194.
Kearns AM, Draper B, Wipat W, Turner AJL, Wheeler J, Freeman R, Harwood J, Gould FK, Dark JH. LightCycler-based quantitative PCR for detection of cytomegalovirus in blood, urine, and respiratory samples .
Journal of Clinical Microbiology 2001, 39 (6), 2364-2365.
Langley P, King ST, Dark JH, Murray A. Relationship between QT dispersion and a heart failure survival score .
Computers in Cardiology 2001, 28 , 649-652.
Hornung TS, de Goede CGEL, O'Brien C, Moghal NE, Dark JH, O'Sullivan JJ. Renal function after pediatric cardiac transplantation: The effect of early cyclosporin dosage .
Pediatrics 2001, 107 (6), 1346-1350.
Zaglavara T, Karvounis H, Gemitzis K, Cumberledge B, Kenny A, Dark J, Hasan A, Hamilton JRL, Louridas G. Time course and magnitude of improvement in resting LV function, contractile reserve and functional capacity in patients with hibernating myocardium undergoing surgical revascularization .
In: European Heart Journal: XXIII Congress of the European Society of Cardiology . 2001, Stockholm, Sweden: Oxford University Press.
Gok MA, Shenton BK, Cornell C, Peaston R, Aitchison JD, Dark JH, Talbot D, Mantle D. Viability assessment of non-heart beating donor kidneys: Alanine-aminopeptidase and glutathione s-transferase: An animal model .
In: ECCP 2001: The Fifth European Comparative Clinical Pathology Conference . 2001, Edinburgh, Scotland: Springer.
Curtis HJ, Parry G, Dark JH. What have we learnt from the Alder Hey affair? February 2001 seems to have been average month for organ donations in Newcastle .
British Medical Journal 2001, 322 (7301), 1541-1541.
Fisher AJ, Wardle J, Dark JH, Corris PA. Acute lung injury after lung transplantation: Risk factors and long term survival implications .
Thorax 2000, 55 (3), A2-.
Christie G, Rao J, Hilton CJ, Forty J, Hassan A, Pillay T, Dark JH, Corris PA. Lung transplantation for non cystic fibrosis bronchiectasis .
In: THORAX . 2000.
De Soyza A, Corris PA, Archer L, McDowell A, Moore J, Elborn S, Dark JH, Gould K. Pulmonary transplantation for CF; The effect of B. cepacia genomovars on outcomes .
In: THORAX . 2000.
Langley P, Dark JH, Murray A. QT dispersion analysis of a transplant assessment group .
In: Computers in Cardiology . 2000, Cambridge, MA, USA: Institution of Electronic and Electrical Engineers.
Melville AMS, Wardle J, Hasan A, Pillay T, Hilton CJ, Forty J, Dark JH, Corris PA. Single lung transplantation for emphysema: 1987-2000 and beyond .
In: THORAX . 2000.
Clark SC, Sudarshan C, Roughan J, Flecknell PA, Dark JH. Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and SIN-1 .
Journal of Thoracic and Cardiovascular Surgery 1999, 117 (3), 556-564.
De Soyza A, Dark JH, Hasan A, Parry G, Ledingham S, Hilton C, Gould K, Forty J, Corris PA. Pulmonary transplantation for cystic fibrosis (CF): The Newcastle experience over 10 years .
In: Thorax . 1999, BMJ Group.
Wardle J, De Soyza A, Dark JH, Hasan A, Hilton C, Gould K, Forty J, Ledingham S, Corris PA. Pulmonary transplantation in cystic fibrosis (CF): Second organ dysfunction at 3 years post transplantation .
In: Thorax . 1999, BMJ Group.
