Newcastle University

Introduction

My clinical interests are gynaecological and placental pathology. My research for many years has focised on the immunobiology of humna pregnancy with particular emphasis on the relationship between maternal and fetal cells in the placental bed.

• C. E. Shulman, E. K. Dorman, F. Cutts, K. Kawuondo, J. N. Bulmer, N. Peshu and K. Marsh. Intermittent sulphadoxine-pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial. Lancet 1999, 353, 632-636.
• N. Vassiliadou, R. F. Searle and J. N. Bulmer. Elevated expression of activation molecules by decidual lymphocytes in women suffering spontaneous early pregnancy loss. Human Reproduction 1999, 14, 1194-1200.
• N. Vassiliadou and J. N. Bulmer. Functional studies of human decidua in spontaneous early pregnancy loss: Effect of soluble factors and purified CD56+ lymphocytes on killing of natural killer- and lymphokine- activated killer-sensitive targets. Biology of Reproduction 1998, 58, 982-987.
• Shulman CE, Dorman EK, Cutts F, Kawuondo K, Bulmer JN, Peshu N and Marsh K. Preventing severe anaemia secondary to malaria in pregnancy: a double blind randomised placebo controlled trial of intermittent sulfaxdoxine-pyrimethamine. The Lancet 1999, 353, 632-636.
• Champion H, Innes BA, Robson SC, Lash GE, Bulmer JN. Effects of interleukin-6 on extravillous trophoblast invasion in early human pregnancy. Molecular Human Reproduction 2012, (epub ahead of print).
• Champion H, Innes BA, Robson SC, Lash GE, Bulmer JN. Effects of interleukin-6 on extravillous trophoblast invasion in early human pregnancy. Molecular Human Reproduction 2012. In Press.
• Bulmer JN, Burton GJ, Collins S, Cotechini T, Crocker IP, Croy BA, Cvitic S, Desforges M, Deshpande R, Gasperowicz M, Groten T, Haugen G, Hiden U, Host AJ, Jirkovska M, Kiserud T, Konig J, Leach L, Murthi P, Pijnenborg R, Sadekova ON, Salafia CM, Schlabritz-Loutsevitch N, Stanek J, Wallace AE, Westermeier F, Zhang J, Lash GE. IFPA Meeting 2011 workshop report II: Angiogenic signaling and regulation of fetal endothelial function; placental and fetal circulation and growth; spiral artery remodeling. Placenta 2012, 33(supplement), S9-S14.
• Bulmer JN, Burton GJ, Collins S, Cotechini T, Crocker IP, Croy BA, Cvitic S, Desforges M, Deshpande R, Gasperowicz M, Groten T, Haugen G, Hiden U, Host AJ, Jirkovská M, Kiserud T, König J, Leach L, Murthi P, Pijnenborg R, Sadekova ON, Salafia CM, Schlabritz-Loutsevitch N, Stanek J, Wallace AE, Westermeier F, Zhang J, Lash GE. IFPA Meeting 2011 workshop report II: Angiogenic signaling and regulation of fetal endothelial function; placental and fetal circulation and growth; spiral artery remodeling. Placenta 2012, 33, S9-S14.
• Ackerman WE, Bulmer JN, Carter AM, Chaillet JR, Chamley L, Chen CP, Chuong EB, Coleman SJ, Collet GP, Croy BA, de Mestre AM, Dickinson H, Ducray J, Enders AC, Fogarty NME, Gauster M, Golos T, Haider S, Heazell AE, Holland OJ, Huppertz B, Husebekk A, John RM, Johnsen GM, Jones CJR, Kalionisv B, Konig J, Lorenzon AR, Moffett A, de Mello JCM, Nuzzo AM, Parham P, Parolini O, Petroff MG, Pidoux G, Ramirez-Pinilla MP, Robinson WP, Rolfo A, Sadoysky Y, Soma H, Southcombe JH, Tilburgs T, Lash GE. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta 2012, 33(supplement), S15-S22.
• Ackerman WE, Bulmer JN, Carter AM, Chaillet JR, Chamley L, Chen CP, Chuong EB, Coleman SJ, Collet GP, Croy BA, de-Mestre AM, Dickinson H, Ducray J, Enders AC, Fogarty NM, Gauster M, Golos T, Haider S, Heazell AE, Holland OJ, Huppertz B, Husebekk A, John RM, Johnsen GM, Jones CJ, Kalionis B, König J, Lorenzon AR, Moffett A, Moreira-de-Mello JC, Nuzzo AM, Parham P, Parolini O, Petroff MG, Pidoux G, Ramírez-Pinilla MP, Robinson WP, Rolfo A, Sadovsky Y, Soma H, Southcombe JH, Tilburgs T, Lash GE. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta 2012, 33, S15-22.
• Kitson S, Macphail S, Bulmer J. Is pregnancy safe after uterine artery embolisation?. British Journal of Obstetrics and Gynaecology 2012. In Press.
• Lash GE, Innes BA, Drury JA, Robson SC, Quenby S, Bulmer JN. Localization of angiogenic growth factors and their receptors in the human endometrium throughout the menstrual cycle and in recurrent miscarriage. Human Reproduction 2012, 27(1), 183-195.
• Bulmer JN, Levey J, Innes BA, Robson SC, Lash GE. The role of vascular smooth muscle cell apoptosis and migration during transformation of uterine spiral arteries in normal human pregnancy. FASEB Journal 2012. In Press.
• Bulmer JN, Innes BA, Levey J, Robson SC, Lash GE. The role of vascular smooth muscle cell apoptosis and migration during uterine spiral artery remodeling in normal human pregnancy. FASEB Journal 2012, (epub ahead of print). In Press.
• Robson A, Harris LK, Innes BA, Lash GE, Aljunaidy MM, Aplin JD, Baker PN, Robson SC, Bulmer JN. Uterine natural killer cells initiate spiral artery remodelling in human pregnancy. FASEB Journal 2012, currently undergoing revisions for FASEB J. Submitted.
• Robson A, Lash GE, Innes BA, Robson SC, Bulmer JN. Uterine natural killer cells mediate de-differentiation of spiral arteries in early human pregnancy. To be submitted to Am J Pathol 2012. In Preparation.
• Lash GE, Bulmer JN. Do uterine natural killer (uNK) cells contribute to female reproductive disorders?. Journal of Reproductive Immunology 2011, 88(2), 156-164.
• Otun HA, Lash GE, Innes BA, Bulmer JN, Naruse K, Hannon T, Searle RF, Robson SC. Effect of tumour necrosis factor-alpha in combination with interferon-gamma on first trimester extravillous trophoblast invasion. Journal of Reproductive Immunology 2011, 88(1), 1-11.
• Lash GE, Robson A, Innes BA, Robson SC, Bulmer JN. Extracellular matrix components of the human uterine spiral artery wall differ in a spatial and temporal manner. In: Placenta: Meeting of the International Federation of Placenta Associations (IFPA). 2011, Geilo, Norway: Elsevier Ltd.
• Lash GE, Naruse K, Robson A, Innes BA, Searle RF, Robson SC, Bulmer JN. Interaction between uterine natural killer cells and extravillous trophoblast cells: effect on cytokine and angiogenic growth factor production. In: Journal of Reproductive Immunology: 9th Congress of the European Society for Reproductive Immunology. 2011, Copenhagen, Denmark: Elsevier Ireland Ltd.
• Ellis N, Innes BA, Lash GE, Robson SC, Bulmer JN. Loss of endothelial cells in spiral artery remodeling: Myths versus facts. In: Placenta: Meeting of the International Federation of Placenta Associations (IFPA). 2011, Geilo, Norway: Elsevier Ltd.
• Williams PJ, Bulmer JN, Innes BA, Pipkin FB. Possible Roles for Folic Acid in the Regulation of Trophoblast Invasion and Placental Development in Normal Early Human Pregnancy. Biology of Reproduction 2011, 84(6), 1148-1153.
• Lash GE, Bulmer JN, Innes BA, Drury JA, Robson SC, Quenby S. Prednisolone treatment reduces endometrial spiral artery development in women with recurrent miscarriage. Angiogenesis 2011, 14(4), 523-532.
• Scaife PJ, Searle RF, Robson SC, Innes BA, Bulmer JN. Comparison of decidual leucocyte populations in spontaneous early pregnancy loss.. In: Journal of the Society for Gynecologic Investigation. 2004, Houston, Texas, USA: Sage Publications Ltd..
• Lash GE, Otun HA, Innes B, Searle RF, Bulmer JN, Robson SC. Culture of placental villous explants in 8% oxygen does not alter their invasive phenotype. In: Conference of the Placenta Association of the Americas/10th Meeting of the International Federation of Placenta. 2004, Asilomar, CA: Placenta: WB Saunders Co. Ltd.
• Scaife PJ, Searle RF, Innes BA, Robson SC, Bulmer JN. Cytokine production by CD8+ decidual leucocytes in early pregnancy. Gynecologic and Obstetric Investigation 2004, 11(2, Supplement), 628A.
• Scaife PJ, Searle RF, Robson SC, Innes BA, Bulmer JN. Cytokine production by CD8+decidual leucocytes in early pregnancy. In: Journal of the Society for Gynecologic Investigation: 51st Annual Meeting of the Society for Gynecologic Investigation. 2004, Houston, Texas, USA: Sage Publications, Inc.
• Lash GE, Otun HA, Innes B, Searle RF, Bulmer JN, Robson SC. Inhibition of extravillous trophoblast cell invasion in 3% oxygen is due to an increase in PAI-2 production. In: Conference of the Placenta Association of the Americas/10th Meeting of the International Federation of Placenta. 2004, Asilomar, CA: Placenta: WB Saunders Co. Ltd.
• Lash GE, Otun HA, Innes B, Bulmer JN, Searle RF, Robson SC. Invasion of extravillous trophoblast cells is inhibited in low oxygen conditions. In: Journal of the Society for Gynecologic Investigation. 2004, Houston, Texas, USA: Sage Publications, Inc..
• Staunton MJ, Cross PA, Bulmer JN. Lack of interobserver agreement in the diagnosis of endometrial cytological atypia and endometrial hyperplasia. In: Journal of Pathology: 186th Meeting of the Pathological Society of Great Britain and- Ireland/Dutch Pathological Society. 2004, Amsterdam, Netherlands: John Wiley & Sons Ltd..
• Otun HA, Lash GE, Innes B, Bulmer JN, Searle RF, Robson SC. Regulation of trophoblast invasion by TGF-beta: Role of apoptosis and proliferation.. In: Journal of the Society for Gynecologic Investigation. 2004, Houston, Texas, USA: Sage Publications Ltd..
• Kilby MD, Barber KJ, Bulmer JN, Franklyn JA, Whitley GSJ. The effects of thyroid hormone on cytokine-induced proliferation in human trophoblast cells. In: 51st Annual Meeting of the Society for Gynecologic Investigation. 2004, Houston, Texas: Journal of the Society for Gynecologic Investigation: Elsevier.
• Scaife PJ, Searle RF, Robson SC, Innes BA, Bulmer JN. [abstract] A comparison of cytotoxic decidual lymphocytes in early and late pregnancy. Journal of the Society for Gynecologic Investigation 2003, 10(2 (supplement)), 360A.
• Phillips PJ, Innes BA, Searle RF, Bulmer JN, Robson SC. [abstract] Use of laser capture microdissection and RT-PCR to study gene expression in heterogeneous differentiating trophoblast populations. Journal of the Society for Gynecologic Investigation 2003, 10(2, supplement), 398A.
• Otun HA, Lash GE, Bulmer JN, Searle RF, Robson SC. Inhibition of first trimester human extravillous trophoblast invasion by TNF-alpha and IFN-gamma. In: 10th European Placenta Group Meeting: Comparative, Experimental and Clinical Aspects of Placentation. 2003, Mainz, Germany.
• Bulmer JN, Innes BA, Searle RF, Robson SC. M30 is expressed by extravillous trophoblast in the placental bed in the first half of normal human pregnancy. Journal of the Society for Gynecologic Investigation 2003, 10(2 (supplement)), 394A.
• Otun HA, Searle RF, Bulmer JN, Robson SC. The effect of TGF beta inhibition on trophoblast invasion. Journal of the Society for Gynecologic Investigation 2003, 10(2 (Supplement)), 397A.
• Pongcharoen S, Bulmer JN, Searle RF. Lack of apoptotic decidual leucocytes in hydatidiform mole: no evidence for Fas-Fas ligand system mediated maternal T cell tolerance in molar pregnancy. Immunology 2002, 107(s1), 124.
• Disep B, Bulmer JN. Lymphocyte distribution in inflamed endometria. Journal of Pathology 2002, 198(supplement), 17A.
• Zehnder D, Evans KN, Kilby MD, Bulmer JN, Innes BA, Stewart PM, Hewison M. The ontogeny of 25-hydroxyvitamin D-3 1 alpha-hydroxylase expression and decidua. American Journal of Pathology 2002, 161(1), 105-114.
• Searle RF, Wongweragiat S, Bulmer JN. Maternal immune tolerance during molar pregnancy: increased expression of Fas ligand on abnormal trophoblast induces apoptosis of activated decidual leucocytes. In: VIII International Congress of Reproductive Immunology. 2001, Opatija, Croatia: Wiley-Blackwell Publishing, Inc.
• Stewart JA, Bulmer JN, Searle RF, Murdoch AP. Endometrial steroid hormone receptor in relation to unexplained sub-fertility and parity. J Reproduction and Fertility 2000, Abstract Series No 25, 46.