Dr Luke Gaughan
University Research Fellow
- Email: luke.gaughan@ncl.ac.uk
- Telephone: 0191 246 4360
- Fax: 0191 246 4301
- Address: Northern Institute for Cancer Research
Paul O'Gorman Building
Medical School
Framlington Place
Newcastle upon Tyne
NE2 4HH
Research Interests
1. Mechanisms of Androgen Receptor Regulation in Prostate Cancer
2. Epigenetics and Transcription
Current Work
Histone methyltransferases (HMTs), histone acetyltranferases (HATs) and the enzymes that reverse the effects of these proteins play a fundamental role in regulating transcription. My PhD student Nan Wang and I are deciphering the role of the HMT SET9 in androgen receptor (AR) regulation and prostate cancer development.
We are also assessing interplay between SET9 and members of the HAT and histone deacetylase (HDAC) families in an attempt to establish ordered mechanisms of co-regulator function during AR-mediated transcription that could provide novel therapeutic targets for prostate cancer treatment.
As part of a long term collaboration with Dr. Ian Mills, Cancer Research UK Cambridge Research Institute, studying the role of HIP-1 in AR function, we are currently investigating novel mechanisms of HIP-1 regulation.
Postgraduate Supervision
1 Marie-Curie-funded Ph.D student
1 Masters of Research (MRes) student.
Esteem Indicators
Invited Speaker:
1. Institute of Medical Technology Research Day 2006, University of Tampere, Finland.
2. National Cancer Research Institute (NCRI) 2006, International Conference Centre, Birmingham.
3. Androgens 2006, University of Cambridge.
Funding
Association for International Cancer Research
Funding my work between 2004-2007
Qualifications
1998: B.SC (Hons) Biochemistry.
Newcastle University
2001: Ph.D Molecular Biology
Urology Research Group
School of Surgical and Reproductive Sciences
Newcastle University
Previous Positions
2001- 2006: Post-Doctoral Research Associate.
Urology Research Group,
Northern Institute For Cancer Research,
Newcastle University.
Funded by the Association for International Cancer Research (AICR)
Memberships
British Association for Cancer Research (BACR)
Endocrine Society
Honours and Awards
British Association for Cancer Research Young Translational Scientist Award 2006
Genes and Cancer Poster Prize 2005.
