Newcastle University

Introduction

I am an ophthalmologist with a specialist interest in the visual problems of children. I undertake clinical research in this area with the aim of improving the effectiveness and efficiency of the delivery of children's ophthalmic services. I am theme leader for vision research in the Newcastle Specialist Biomedical Research Centre for Ageing. My research interest in this field is the relationship between ocular and cerebral pathology in visual symptoms experienced by elderly patients, particularly those with early dementia.

Roles and Responsibilities

Leader, Vision Theme, Specialist Biomedical Research Centre for Ageing

Qualifications

MA MB BChir DO FRCS FRCOphth

Previous Positions

House Physician, Addenbrookes' Hospital 1982.
House Surgeon, Manchester Royal Infirmary 1982-3.
Casualty Officer, University College Hospital, London 1983.
S.H.O. Ophthalmology, St. Bartholomew's Hospital, London 1984.
S.H.O. Ophthalmology, Western Ophthalmic Hospital, London
1984-5.
S.H.O. Medical and Surgical Neurology, Addenbrookes' Hospital, Cambridge 1985-6.
Registrar in Ophthalmology, West Yorkshire Rotation, 1986-1988.
Senior Registrar in Ophthalmology, Nottingham University Hospital, 1988-1990.
Clinical Fellow, Ophthalmology Department, Hospital for Sick Children, Toronto 1990-1991.

Memberships

Royal College of Ophthalmologists
Association for Research in Vision and Ophthalmology
American Association for Pediatric Ophthalmology and Strabismus
Editorial Board, Journal of Pediatric Ophthalmology and Strabismus

Honours and Awards

Nettleship Research Medal of Royal College of Ophthalmologists 2006

Informal Interests

Volunteer Faculty, Orbis India Childhood Blindness Programme

Research Interests

Ocular Misalignment (Strabismus) especially Intermittent Exotropia
Amblyopia
Visual aspects of Non Accidental Injury
Visual impairment in Dementias and Parkinson's Disease

Current Work

Cohort study of intermittent exotropia

Research Roles

Lead, Vision theme, Specialist Biomedical Centre for Ageing
Non Executive Chair, Ulverscroft Vision Research Group, Institute of Child Health, London

Postgraduate Supervision

Esteem Indicators

Chairman, Paediatric Committee, Royal College of Ophthalmologists
Member, Professional Standards Committee, Royal College of Ophthalmologists

Undergraduate Teaching

Stage 2 TSM Vision Module
Accelerated Program Vision Lecture
MRes Ageing Lecture
SSC Option supervisor

Postgraduate Teaching

Departmental Thurs am
Regional Weds pm
Invited Lectures to other ophthalmology departments
Examiner, RCOphth

• Buck D, Powell CJ, Rahi J, Cumberland P, Tiffin P, Taylor R, Slope J, Davis H, Dawson E, Clarke MP. The improving outcomes in intermittent exotropia study: outcomes at 2 years after diagnosis in an observational cohort. BMC Ophthalmology 2012, 12(1), 1.
• Jefferis JM, Mosimann UP, Taylor JP, Clarke MP. "Do your eyes play tricks on you?" Asking older people about visual hallucinations in a general eye clinic. International Psychogeriatrics 2011, 23(6), 1014-1015.
• Jefferis JM, Mosimann UP, Clarke MP. Republished review: Cataract and cognitive impairment: a review of the literature. Postgraduate Medical Journal 2011, 87(1031), 636-642.
• Archibald NK, Clarke MP, Mosimann UP, Burn DJ. Retinal thickness in Parkinson's disease. Parkinsonism & Related Disorders 2011, 17(6), 431-436.
• Buck D, Clarke MP, Powell C, Tiffin P, Drewett RF. Use of the PedsQL in childhood intermittent exotropia: estimates of feasibility, internal consistency reliability and parent-child agreement. Quality of Life Research 2011, (epub ahead of print).
• Serrano-Pedraza I, Manjunath V, Osunkunle O, Clarke MP, Read JCA. Visual Suppression in Intermittent Exotropia during Binocular Alignment. Investigative Ophthalmology & Visual Science 2011, 52(5), 2352-2364.
• Archibald NK, Clarke MP, Mosimann UP, Burn DJ. Visual symptoms in Parkinson's disease and Parkinson's disease dementia. Movement Disorders 2011, 26(13), 2387-2395.
• Porteous AM, Clarke MP. Medically unexplained visual symptoms in children and adolescents: an indicator of abuse or adversity?. Eye 2009, 23(9), 1866-1867.
• Nassar MM, Dickinson AJ, Neoh C, Powell C, Buck D, Galal E, Clarke MP. Parameters predicting outcomes of strabismus surgery in the management of Graves' ophthalmopathy. In: Journal of AAPOS: 33rd Annual Meeting of the American Association for Pediatric Ophthalmology and Strabismus. 2009, Seattle, Washington, USA: Mosby, Inc..
• Archibald NK, Clarke MP, Mosimann UP, Burn DJ. The retina in Parkinson’s disease: A review. Brain 2009,132 5 1128-1145.
• Clarke MP. Vitreoretinal traction is a major factor in causing the haemorrhagic retinopathy of abusive head injury? - No. Eye 2009. London:Nature Publishing Group,23 9 1761-1763.
• Mosimann UP, Collerton D, Dudley R, Meyer TD, Graham G, Dean JL, Bearn D, Killen A, Dickinson L, Clarke MP, McKeith IG. A semi-structured interview to assess visual hallucinations in older people. International Journal of Geriatric Psychiatry 2008, 23(7), 712-718.
• Buck D, Clarke MP, Haggerty H, Hrisos S, Powell C, Sloper J, Strong NP. Grading the severity of intermittent distance exotropia: The revised Newcastle Control Score. British Journal of Ophthalmology 2008. , 92(4), 577.
• Clarke MP. Intermittent exotropia. Journal of Pediatric Ophthalmology and Strabismus 2007. , 44(3), 153-157.
• Holmes JM, Clarke MP. Amblyopia. The Lancet 2006. , 367(9519), 1343-1351.
• Clarke MP. Modern Treatment of Amblyopia. In:Lorenz, B., Moore, A.T., ed. Pediatric Ophthalmology, Neuro-Ophthalmology, Genetics.Berlin, Germany:Springer,2006, pp. 37-48.
• Hrisos S, Clarke MP, Kelly T, Henderson J, Wright CM. Unilateral visual impairment and neurodevelopmental performance in preschool children. British Journal of Ophthalmology 2006,90 7 836-838.
• Adams WE, Hrisos S, Richardson S, Davis H, Frisby JP, Clarke MP. Frisby Davis distance stereoacuity values in visually normal children. British Journal of Ophthalmology 2005, 89(11), 1438-1441.
• Richardson SR, Wright CM, Hrisos S, Buck D, Clarke MP. Stercoacuity unilateral visual impairment detected at preschool screening: Outcomes from a randomized controlled trial. Investigative Ophthalmology and Visual Science 2005, 46(1), 150-154.
• Clarke MP. Reform of undergraduate medical teaching in the United Kingdom: Evangelism triumphs over common sense for ophthalmology. British Medical Journal 2004. ,329 7469 799-800.
• Richardson SR, Clarke MP. Surgery for Intermittent Exotropia. International Review of Modern Surgery 2004,36–37.
• Hrisos S, Clarke MP, Wright CM. The emotional impact of amblyopia treatment in preschool children: Randomized controlled trial. Ophthalmology 2004,111 8 1550-1556.
• Haggerty H, Richardson S, Hrisos S, Strong NP, Clarke MP. The Newcastle Control Score: a new method of grading the severity of intermittent exotropia. British Journal of Ophthalmology: 2004,88 2 233-235.
• Mckie JN, Mohamed J, Li Z, Arris CE, Hiscott P, Sheridan C, Langton KP, Barker MD, Clarke MP, Bevitt DJ. Expression of ADAMTS metalloproteinases in ARPE19 cells: Transcriptional regulation by TNF alpha. In: Investigative Ophthalmology & Visual Science: Annual Meeting of the Association for Research in Vision and Ophthalmology. 2003, Ft Lauderdale, Florida, USA: Association for Research in Vision and Ophthalmology.
• Ressiniotis T, Zeki SM, Clarke MP, Mitchell KW. Improved illumination for the Perkins applanation tonometer.. Ophthalmic and Physiological Optics 2003,23 6 513-516.
• Henderson A, Lynch SA, Clarke M, Williamson K, van Heyningen V. Microphthalmia associated with neurofibromatosis 1 and PAX6 mutation. In: Journal of Medical Genetics: British Human Genetics Conference. 2003, York, UK: BMJ Group.
• Clarke MP, Wright CM, Hrisos S, Anderson JD, Henderson J, Richardson SR. Randomised controlled trial of treatment of unilateral visual impairment detected at preschool vision screening. British Medical Journal 2003,327 7426 1251-1254.
• Clarke MP, Haggerty H, Richardson S, Hrisos S. Surgical decision making in intermittent distance exotropia using the newcastle control score. In: Investigative Ophthalmology & Visual Science: Annual Meeting of the Association for Research in Vision and Ophthalmology. 2003, Ft Lauderdale, Florida, USA: Association for Research in Vision and Ophthalmology.
• Clarke M, Richardson S, Hrisos S, Anderson J, Henderson J, Wright C. The UK amblyopia treatment trial: Visual acuity and stereoacuity values in treated and untreated unilateral straight eyed amblyopia. In: Progress in Strabismology: 9th Meeting of the International Strabismological Association. 2003, Sydney, Australia: Taylor & Francis.
• Brennan R, Clarke MP, Redfearn A, Gibson M, Lazaro C, Mitchell KW. Visual impairment following shaking/impact injury in infancy: A clinical and electrophysiological study. In: Investigative Ophthalmology & Visual Science: Annual Meeting of the Association for Research in Vision and Ophthalmology. 2003, Ft Lauderdale, Florida, USA: Association for Research in Vision and Ophthalmology.
• Clarke M. The assessment and management of strabismus in childhood. Current Paediatrics 2002, 12(4), 269-274.
• Herrema I, Clarke M. Anaesthesia for retinoblastoma screening - a dilemma. Anaesthesia 2001, 56(5), 486-487.
• Clarke M, Mitchell KW, Goodship J, McDonnell S, Barker MD, Griffiths ID, McKie N. Clinical features of a novel TIMP-3 mutation causing Sorsby's fundus dystrophy: implications for disease mechanism. British Journal of Ophthalmology 2001, 85(12), 1429-1431.
• Griffiths PG, Barron MJ, Durham S, Johnson MA, Bristow E, Clarke MP, Lai-Cheong J, Turnbull DM. Distribution of mitochondrial dysfunction in ageing ocular tissues. In: Annual Meeting of the Association for Research in Vision and Ophthalmology. 2001, Fort Lauderdale, Florida, USA: Association for Research in Vision and Ophthalmology.
• Hrisos S, Clarke MP, Anderson JD, Wright C. Emotional Impact of Amblyopia Treatment on Preschool Children. In: Annual Meeting of the American Academy of Ophthalmology (AAO). 2001, New Orleans, Louisiana, USA.
• Barron MJ, Johnson MA, Andrews RM, Clarke MP, Griffiths PG, Bristow E, He L, Durham S, Turnbull DM. Mitochondrial abnormalities in ageing macular photoreceptors. Investigative Ophthalmology and Visual Science 2001, 42(12), 3016-3022.
• Boyle NJ, Clarke MP, Figueiredo F. Reduced corneal sensation and severe dry eyes in a child with fetal valproate syndrome. Eye 2001, 15(5), 661-662.
• Ziakas NG, Cottrell DG, Milligan DWA, Pennefather PM, Bamashmus MA, Clarke MP. Regionalisation of retinopathy of prematurity (ROP) screening improves compliance with guidelines: an audit of ROP screening in the Northern Region of England. British Journal of Ophthalmology 2001, 85(7), 807-810.
• McKie JN, Bevitt DJ, Lorite MJ, Pimenides D, Clarke MP, Langton KP, Barker MD. RPE cells express several members of the metallo-disintegrin (ADAM) family of extracellular matrix modifying enzymes. Investigative Ophthalmology & Visual Science 2001, 42(4), 1197.
• Ziakas NG, Wong CP, Ramsay AS, Bamashmus MA, Forsyth RJ, Eyre JA, Clarke MP. Visual impairment in children with acute non-traumatic coma. Journal of Pediatric Ophthalmology and Strabismus 2001,38 1 6-10.
• Clarke MP, Barker MD, Langton KP, Curtis A, Goodship JA, Bond PM, Mitchell KA, McKie N. A novel TIMP-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy. In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2000.
• Langton KP, McKie N, Curtis A, Goodship JA, Bond PM, Barker MD, Clarke M. A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy. Journal of Biological Chemistry 2000, 275(35), 27027-27031.
• Barron MJ, Andrews RM, Griffiths PG, Johnson MA, Bristow E, He LP, Durham S, Turnbull DM, Clarke MP. The macular photoreceptor layer accumulates the mitochondrial DNA(4977) deletion with age. In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2000.
• Pennefather PM, Tin W, Clarke MP, Dutton J, Fritz S, Hey EN. Bias due to incomplete follow up in a cohort study. Brit. J. Ophthalmol 1999, 83, 643-645.
• Hanson I, Churchill A, Love J, Axton R, Moore T, Clarke M, Meire F, van Heyningen V. Missense mutations in the most ancient residues of the PAX6 paired domain underlie a spectrum of human congenital eye malformations.. Human Molecular Genetics 1999, 83, 513-518.
• Pennefather PM, Clarke MP, Strong NP, Cottrell DG, Dutton J, Tin W. Risk factors for strabismus in children born before 32 weeks' gestation.. Brit. J. Ophthalmol. 1999, 83, 513-518.
• Stephanous SN, Clarke MP, Ashton H, Mitchell KW. The effect of long term use of benzodiazepines on the eye and retina. Documenta Ophthalmologica 1999, 99, 55-68.
• Gilchrist ID, Brown V, Findlay JM, Clarke MP. Using the eye-movement system to control the head.. Proc. R. Soc .Lond. B 1998, 265, 1831-1836.
• Clarke M., Mitchell KW, McDonnell S. Electrophysiology in macular dystrophies.. Documenta Ophthalmologica 1997, 92, 325 - 339.
• Pennefather PM, Tin W, Strong NP, Clarke MP, Dutton J, Cottrell DG. Refractive errors at two years of infants born before 32 weeks gestation.. Eye 1997, 11, 736-743.
• Clarke MP, Mitchell KW, Gibson M. The prognostic value of flash visual evoked potentials in the assessment of non-ocular visual impairment in infancy in infants.. Eye 1997, 11, 398-402..
• Bray LC, Clarke MP, Jarvis SM, Francis PM, Colver A. Pre School Vision Screening: A Prospective Comparative Evaluation. Eye 1996, 10, 714-718.
• MacLean H, Clarke MP, Strong NP, Kernahan J, Ashraf S. Primary ocular relapse in acute lymphoblastic leukaemia.. Eye 1996 1996, 10, 719-722..
• Pennefather PM, Tin W, Clarke MP, Fritz S, Strong NP. Retinopathy of prematurity in a controlled trial of prophylactic surfactant treatment.. British Journal of Ophthalmology 1996, 80, 420-424.
• Sullivan TJ, Clarke MP, Tuli R, Devenyi R, Harvey P. General Anaesthesia with endotracheal intubation for cryotherapy for retinopathy of prematurity.. European Journal of Ophthalmology 1995, 5(3), 187-191.
• Pennefather PM, Clarke MP, Strong NP, Cotterell D, Fritz S, Tin W. Ocular outcome in children born before 32 weeks gestation.. Eye 1995, 9 (Suppl.), 26-30.
• West J, Askin G, Clarke M, Vernon S. Loss of vision following scoliosis surgery. Br. J. Ophthalmol. 1990, 74(243-244).
• Clarke M., Vernon S., Pearson J., Matthews C. The effect of pupil size on measurements of lens opacity with the Lens Opacity Meter 701.. British Journal of Ophthalmology 1990, 74, 526-527.
• Clarke M., Yap M., Weatherill J. Do intraocular lenses containing ultraviolet filters protect against macular oedema?. Acta Ophthalmologica 1989, 67, 593-596.
• Clarke M., Yap M., Weatherill J. Pattern ERG and Contrast Sensitivity findings in Waldenstrom's Macroglobulinaemia.. Eye 1987, 1, 750-753.
• Clarke M., Jagger J. Is acute glaucoma a symptom of diabetes?. British Journal of Ophthalmology 1986, 70, 877-878.