Professor Nicholas Simmons
Professor of Epithelial Physiology
- Email: nicholas.simmons@ncl.ac.uk
- Telephone: +44 (0) 191 222 6999
- Fax: +44 (0) 191 222 7424
- Personal Website: http://research.ncl.ac.uk/epithelia/
- Address: Institute for Cell and Molecular Biosciences
Medical School
University of Newcastle upon Tyne
Catherine Cookson Building
Framlington Place
Newcastle upon Tyne
NE2 4HH
Research Interests
Integration of gene expression with epithelial function with special focus on intestinal and renal systems. Ion channels. Drug delivery, clearance and disposition.
- Wright JA, Haslam LS, Coleman T, Simmons NL. Breast cancer resistance protein BCRP (ABCG2)-mediated transepithelial nitrofurantoin secretion and its regulation in human intestinal epithelial (Caco-2) layers. European Journal of Pharmacology 2011, 672(1-3), 70-76.
- Carr G, Wright JA, Simmons NL. Epithelial Barrier Resistance is Increased by the Divalent Cation Zinc in Cultured MDCKII Epithelial Monolayers. Journal of Membrane Biology 2010,237 2-3 115-123.
- Simmons NL, Chaudhry AS, Graham C, Scriven ES, Thistlethwaite A, Smith CP, Stewart GS. Dietary regulation of ruminal bovine UT-B urea transporter expression and localization. Journal of Animal Science 2009, 87(10), 3288-3299.
- Carr G, Moochhala SH, Eley L, Vandewalle A, Simmons NL, Sayer JA. The Pyrophosphate Transporter ANKH is Expressed in Kidney and Bone Cells and Colocalises to the Primary Cilium/Basal Body Complex. Cellular Physiology and Biochemistry 2009, 24(5-6), 595-604.
- Linley JE, Boese SH, Simmons NL, Gray MA. A Voltage-Dependent Ca2+ Influx Pathway Regulates the Ca2+-Dependent Cl- Conductance of Renal IMCD-3 Cells. Journal of Membrane Biology 2009, 230(2), 57-68.
- Moochhala SH, Sayer JA, Carr G, Simmons NL. Renal calcium stones: Insights from the control of bone mineralization. Experimental Physiology 2008, 93(1), 43-49.
- Haslam IS, Jones K, Coleman T, Simmons NL. Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84). Biochemical Pharmacology 2008, 76(7), 850-861.
- Haslam IS, Jones K, Coleman T, Simmons NL. Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells. British Journal of Pharmacology 2008, 154(1), 246-255.
- Haslam IS, Wright JA, O'Reilly DA, Sherlock DJ, Coleman T, Simmons NL. Intestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2). Drug Metabolism and Disposition 2011, 39(12), 2321-2328.
- Lowes S, Simmons NL. Human intestinal cell monolayers are preferentially sensitive to disruption of barrier function from basolateral exposure to cholic acid: Correlation with membrane transport and transepithelial secretion. Pflügers Archiv: European Journal of Physiology 2001, 443(2), 265-273.
- Anderson CMH, Raldua D, Simmons NL, Thwaites DT. pH-dependent forskolin modulation of beta-alanine uptake at the apical surface of Caco-2 cell monolayers. In: Meeting of the Physiological Society. 2001, Sheffield, UK: Wiley-Blackwell Publishing Ltd.
