Newcastle University

Introduction

Dr Quentin M. Anstee is a Clinical Senior Lecturer in the Institute of Cellular Medicine. A practising clinician, he is also an Honorary Consultant Hepatologist in the Liver Unit at the Freeman Hospital, Newcastle.

Dr Anstee's primary research interest is the study of genetic modifiers of progressive liver disease. His translational research has extended from the bench to the bedside with particular focus on the pathogenesis and treatment of Non-Alcoholic Steatohepatitis (NAFLD/NASH) and the role of Coagulation in Hepatic Fibrosis. He is actively involved in ongoing clinical trials of new therapies for fatty liver disease and hepatic fibrosis.

Clinical Expertise

Dr Anstee trained in medicine at University College London where he was awarded First Prize in Medicine in the final MB BS examination (The Philip Seth Belasco & Douglas Cree Prize, 1997).

His post-graduate specialist clinical training in Hepatology/Gastroenterology & General Medicine was undertaken at hospitals in North-West London. Prior to joining ICM, he worked as Clinical Lecturer in Medicine & Hepatology at Imperial College London and St Mary's Hospital from 2007-2010.

Dr Anstee's clinical practice is based in the Regional Liver Unit at the Freeman Hospital. He has expertise in the management of patients with a range of acute and chronic liver conditions including:

• Non-Alcoholic Fatty Liver Disease & Steatohepatitis (NAFLD/NASH)
• Chronic Viral Hepatitis (hepatitis B & hepatitis C)
• Alcoholic Liver Disease
• Autoimmune hepatitis & PBC
• Cirrhosis 

He has a particular sub-specialist interest in the management of non-alcoholic fatty liver disease and, together with Professor Chris Day, runs the regional fatty liver service. He also provides diagnostic and therapeautic Upper GI Endoscopy & Colonoscopy services at the Freeman Hospital and the Royal Victoria Infirmary, Newcastle. 

Qualifications

• BSc(Hons) - 1st Class 'Cell Pathology & Basic Medical Sciences', UCL (1994)
• MB BS with Distinction in Medicine, UCL (1997)
• MRCP(UK), Royal College of Physicians (London, 2000)
• PhD, Imperial College London (2007)

Esteem Indicators

Membership of Editorial Boards:

• Journal of Hepatology

Peer Review Activity:

• International journals including 'Hepatology', 'Journal of Hepatology', 'Gut', 'Liver International', 'Journal of Viral Hepatitis', 'Mammalian Genome' & 'International Journal of Experimental Pathology'
• Grant awarding bodies including the MRC, Wellcome Trust and NIHR.

Invited Lectures at National & International Meetings:

• 'Targeting Patients at Risk of Progressive Non-Alcoholic Fatty Liver Disease - Whom and How?' 47th International Liver Congress, European Association for the Study of the Liver, 2012, Barcelona, Spain.
• 'Experimental Models of NAFLD'  47th International Liver Congress, European Association for the Study of the Liver, 2012, Barcelona, Spain.
• 'Targeted Therapy for Non-Alcoholic Fatty Liver Disease & The Metabolic Syndrome' Frontiers in Hepatology 2011, The Institute of Hepatology, London, UK.
• 'Anticoagulants as Antifibrotics – Current Evidence in Man & Future Trials' 4th International Conference on Coagulopathy in Liver Disease, 2011, London, UK.
• 'NASH - Pathogenesis & Management' Co-chair of Early Morning Workshop, 46th International Liver Congress, European Association for the Study of the Liver, 2011, Berlin, Germany.
• 'The Role of Hypercoagulability in the Pathogenesis of Liver Fibrosis' 46th International Liver Congress, European Association for the Study of the Liver, 2011, Berlin, Germany.
• 'Fatty Liver Disease & The Metabolic Syndrome' Frontiers in Hepatology 2010, The Institute of Hepatology, London, UK.
• 'Pathophysiological Basis of Non-Alcoholic Steatohepatitis' British Association for the Study of the Liver 2010, Edinburgh, UK.
• 'Mechanisms of Fibrogenesis – Metabolic Factors' European Young Hepatologist Workshop 2010, France.
• 'The Role of Hypercoagulation in the Pathogenesis of Liver Fibrosis' 3rd International Conference on Coagulopathy in Liver Disease, 2009, Groningen, The Netherlands.
• 'Mouse Models of NAFLD' British Association for the Study of the Liver 2007, London, UK.
• 'Parenchymal Extinction: Clinical Aspects' Coagulation Disorders in Liver Disease 2007: Currents & Counter-Currents, USA.

Memberships

• Collegiate Member of the Royal College of Physicians of London
• British Association for the Study of the Liver (BASL)
• European Association for the Study of the Liver (EASL)
• American Association for the Study of the Liver (AASLD)
  

Research Interests

Dr Anstee's primary research interest is the study of genetic modifiers of progressive liver disease. His translational research has extended from the bench to the bedside with particular focus on the pathogenesis and treatment of Non-Alcoholic Steatohepatitis (NAFLD/NASH) and the role of Coagulation in Hepatic Fibrosis. He has ongoing fruitful collaborations with both industrial and scientific partners at other UK and international liver units and is a member of the European Union FP7 funded Fatty Liver Inhibition of Progression 'FLIP' Consortium.

Dr Anstee's scientific research has employed gene-driven and phenotype‐driven ethyl-nitrosourea (ENU) mutagenesis screens and more traditional targeted genetic modification techniques to generate and study models of complex genetic disease traits including alcohol addiction, non-alcoholic steatohepatitis, drug induced liver injury (paracetamol toxicity and antibiotic related idiosyncratic drug reactions), primary biliary cirrhosis and liver fibrosis. His research is facilitated by his role as an Honorary Group Leader of the Liver Group at the MRC Mammalian Genetics Unit, MRC Harwell.

His research has led to an MRC Experimental Medicine funded clinical trial examining the efficacy of anticoagulation to slow graft fibrosis in hepatitis C infected liver transplant patients (WAFT-C) and studies of novel therapies in NAFLD/NASH including caspase inhibition and gut flora modulation (RiFL). He is a principal investigator in ongoing clinical trials of new therapies for fatty liver disease and hepatic fibrosis.

Funding

Dr Anstee is the recipient of a HEFCE Clinical Senior Lecturer Award. He has previously received an MRC Clinical Research Fellowship to study genetic modifiers of Non-Alcoholic Steatohepatitis (NASH) & Liver Fibrosis.

He has received research grant funding from sources including the MRC, Wellcome Trust, Academy of Medical Sciences and Imperial College NIHR Biomedical Research Centre.

• Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic DG, MacGowan GA, Anstee QM, Taylor R, Day CP, Trenell MI. Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. Journal of Hepatology 2013, (epub ahead of print).
• Anstee QM, Day CP. S-adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility. Journal of Hepatology 2012, 57(5), 1097-1109.
• Anstee QM, Day CP. A lipid to treat non-alcoholic fatty liver disease – The dawn of ‘lipo-rehabilitation’?. Journal of Hepatology 2012, 56(4), 987-989.
• Dhar A, Anstee QM, Sadiq F, Levene A, Cobbold J, Petts G, Taylor-Robinson S, Goldin R, Thursz MR. A role for anticoagulation in fibrogenesis: Supression of human hepatic stellate cell contractility and liver fibrosis in vitro and vivo. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
• Anstee QM, Darlay R, Leathart JB, Clement J, Clement K, Aithal GP, Valenti L, Van Gaal L, Stickel F, Allison ME, Romero-Gomez M, Andrade RJ, Reeves H, Pihlajamaki J, Bedossa P, Kotronen A, Yki-Jarvinen H, Chalasani NP, Kleiner DE, Rotter J, Burt AD, Ratziu V, Cordell HJ, Daly AK, Day CP. Genome-Wide Association Analysis Confirms Importance of PNPLA3 and Identifies Novel Variants Associated With Histologically Progressive Steatohepatitis in NAFLD. In: 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). 2012, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Possamai LA, Harrison M, Cox RD, Williams R, Anstee QM, Thursz MR, Cox IJ. H-1-NMR metabolic profiling in germ-free and conventionally housed mouse models of acetaminophen-induced hepatotoxicity. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
• Patman GL, Hui KY, Anstee QM, Reeves HL. Kruppel-like factor 6 splice variant 3 (KLF6-SV3) - The redox sensitive splice variant of KLF6 expressed in non-alcoholic steatohepatitis (NASH). In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
• Cobbold JFL, Peake CM, Anstee QM, Yee MS, Thursz MR. Measuring the effectiveness of a multidisciplinary non-alcoholic fatty liver disease clinic. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
• Zeybel M, Hardy T, Wong YK, Mathers JC, Fox CR, Gackowska A, Oakley F, Burt AD, Wilson CL, Anstee QM, Barter MJ, Masson S, Elsharkawy AM, Mann DA, Mann J. Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nature Medicine 2012, 18(9), 1369-U110.
• Patman G, Hui KY, Anstee QM, Reeves HL. Oxidative stress induces alternative splicing and nuclear translocation of kruppel like factor 6. In: Digestive Disorders Federation Meeting. 2012, Liverpool, UK: BMJ Group.
• Levene AP, Kudo H, Armstrong MJ, Thursz MR, Gedroyc WM, Anstee QM, Goldin RD. Quantifying hepatic steatosis - more than meets the eye. Histopathology 2012, 60(6), 971-981.
• Petts G, Dhar A, Kudo H, Sadiq F, Anstee Q, Kallis Y, Dorling A, Goldin R, Thursz M. Targeted inhibition of tissue factor and thrombin on CD31 expressing cells suppresses hepatic fibrosis in CCl4 treated mice. In: Digestive Disorders Federation Meeting. 2012, Liverpool, UK: BMJ Group.
• Petts G, Dhar A, Kudo H, Sadiq F, Anstee QM, Kallis Y, Dorling A, Goldin R, Thursz M. Targeted inhibition of tissue factor and thrombin on CD31 expressing cells supresses hepatic fibrosis in CCL4 treated mice. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
• Petts G, Dhar A, Kudo H, Sadiq F, Anstee QM, Kallis YN, Dorling A, Goldin R, Thursz MR. Targeted inhibition of Tissue Factor suppresses hepatic fibrosis in CCL4 treated mice. In: 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2012, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
• Al-Serri A, Anstee QM, Valenti L, Nobili V, Leathart JBS, Dongiovanni P, Patch J, Fracanzani A, Fargion S, Day CP, Daly AK. The SOD2 C₄₇T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies. Journal of Hepatology 2012, 56(2), 448-454.
• McPherson S, Griffiths L, Hardy T, Henderson E, Burt A, Day C, Anstee QM. The FIB-4 score reliability excludes advanced fibrosis in a diabetic cohort with NAFLD. In: 47th Annual Meeting of the European Association for the Study of the Liver (EASL). 2012, Barcelona, Spain: Elsevier BV.
• Anstee QM, Concas D, Wu B, Potter P, Cox R, Kudo H, Levene A, Goldin RD, Thursz MR, Thomas HC. A novel mouse model of hepatic glycogen storage disease Type 3 identified using a phenotype-driven ethyl-nitrosourea (ENU) mutagensis screen. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
• Levene A, Kudo H, Thursz M, Anstee QM, Goldin RD. Activating Autophagocytosis Decreases Fat Within the Liver. In: Journal of Pathology: 199th Scientific Meeting of the Pathological Society of Great Britain and Ireland. 2011, Cambridge, UK: John Wiley & Sons Ltd.
• Anstee QM. Animal models in nonalcoholic steatohepatitis research: utility and clinical translation. Liver International 2011, 31(4), 440-442.
• McPherson S, Anstee QM, Henderson E, Burt AD, Day CP. Are simple non-invasive scoring systems for fibrosis reliable in patients with NAFLD and normal ALT levels?. In: Hepatology: 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2011, San Francisco, California, USA: John Wiley & Sons, Inc.
• Anstee QM, Daly AK, Day CP. Genetic modifiers of non-alcoholic fatty liver disease progression. Biochimica et Biophysica Acta: Molecular Basis of Disease 2011, 1812(11), 1557-1566.
• Anstee QM, Daly AK, Day CP. Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Seminars in Liver Disease 2011, 31(2), 128-146.
• Patman GL, Anstee Q, Reeves HL. Hepatocellular Carcinoma in NASH: Is there a biological Rationale?. In: 9th Meeting of Therapy in Liver Diseases. 2011, Barcelona, Spain.
• Anstee QM, McPherson S, Day CP. How big a problem is non-alcoholic fatty liver disease?. BMJ 2011, 343, d3897.
• Tripodi A, Anstee QM, Sogaard KK, Primignani M, Valla DC. Hypercoagulability in cirrhosis: causes and consequences. Journal of Thrombosis and Haemostasis 2011, 9(9), 1713-1723.
• Sauvage VR, Levene AP, Nguyen HT, Wood TC, Kudo H, Concas D, Thomas HC, Thursz MR, Goldin RD, Anstee QM, Elson DS. Multi-Excitation Fluorescence Spectroscopy for Analysis of Non-Alcoholic Fatty Liver Disease. Lasers in Surgery and Medicine 2011, 43(5), 392-400.
• Anstee QM, Dhar A, Thursz MR. The role of hypercoagulability in liver fibrogenesis. Clinics and Research in Hepatology and Gastroenterology 2011, 35(8-9), 526-533.
• Concas D, Wu B, Kudo H, Levene A, Thomas HC, Goldin RD, Thursz MR, Anstee QM. Vanin-1 activity modulates the steatosis-steatohepatitis transition in progressive non-alcoholic steatohepatitis. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
• Matthews HC, Concas D, Kudo H, Anstee QM, Thomas H, Cox R, Goldin RD, Thursz MR. Cell surface pantetheinase, Vanin-1, increases oxidative damage in acetaminophen-induced liver injury via a reduction in glutathione. In: 45th Annual Meeting of the European Association for the Study of the Liver. 2010, Vienna, Austria: Journal of Hepatology: Elsevier BV.
• Dhar A, Anstee QM, Kudo H, Goldin R, Thursz MR. Coagulation proteins in acute liver injury: a role in initiation and propagation. In: 45th Annual Meeting of the European Association for the Study of the Liver. 2010, Vienna, Austria: Journal of Hepatology: Elsevier BV.
• Anstee QM, Smith BC, Thomas HC. Hepatitis B and hepatitis C co-infection. In: Foster, G.R., Rajender Reddy, K, ed. Clinical Dilemmas in Viral Liver Disease. Oxford: Wiley-Blackwell, 2010, pp.192-198.
• Anstee QM, Concas D, Kudo H, Levene A, Pollard J, Charlton P, Thomas HC, Thursz MR, Goldin RD. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. Journal of Hepatology 2010, 53(3), 542-550.
• Levene AP, Kudo H, Thursz MR, Anstee QM, Goldin RD. Is oil red-O and digital image analysis the gold standard for quantifying steatosis in the liver?. In: 45th Annual Meeting of the European Association for the Study of the Liver. 2010, Vienna, Austria: Journal of Hepatology: Elsevier BV.
• Levene AP, Kudo H, Thursz MR, Anstee QM, Goldin RD. Is oil red-O staining and digital image analysis the gold standard for quantifying steatosis in the liver?. Hepatology 2010, 51(5), 1859-1859.
• Anstee QM, Possamai LA, Concas D, Wu B, Hassett C, Cox RD, Thomas HC, Thursz MR. Novel quantitative trait locus for acetaminophen-induced hepatotoxicty identified on chromosome 18. In: 45th Annual Meeting of the European Association for the Study of the Liver. 2010, Vienna, Austria: Journal of Hepatology: Elsevier BV.
• Cobbold JFL, Anstee QM, Thomas HC. Rational Testing: Investigating mildly abnormal serum aminotransferase values. British Medical Journal 2010, 341, c4039.
• Possamai LA, Antoniades CG, Anstee QM, Quaglia A, Vergani D, Thursz MR, Wendon J. Role of monocytes and macrophages in experimental and human acute liver failure. World Journal of Gastroenterology 2010, 16(15), 1811-1819.
• Kelly ML, Moir L, Jones L, Whitehill E, Anstee QM, Goldin RD, Hough A, Cheeseman M, Jansson JO, Peters J, Cox RD. A missense mutation in the non-neural G-protein α-subunit isoforms modulates susceptibility to obesity. International Journal of Obesity 2009, 33(5), 507-518.
• Anstee QM, Hoa NT, Sauvage V, Concas D, Levene AP, Thomas H, Thursz MR, Elson D, Goldin R. Autofluorescence: modelling a tool for assessment of steatotic marginal grafts in liver transplantation. In: 60th Annual Meeting of the American Association for the Study of Liver Diseases. 2009, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
• Anstee QM, Wright M, Goldin R, Thursz MR. Parenchymal extinction: coagulation and hepatic fibrogenesis. Clinics in Liver Disease 2009, 13(1), 117-126.
• Cobbold JFL, Anstee QM, Goldin RD, Williams HRT, Matthews HC, North BV, Absalom N, Thomas HC, Thursz MR, Cox RD, Taylor-Robinson SD, Cox IJ. Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. Clinical Science 2009, 116(5-6), 403-413.
• Cobbold JF, Anstee QM, Taylor Robinson SD. The importance of fatty liver disease in clinical practice. In: Annual Meeting of the Nutrition Society and BAPEN. 2009, Cardiff International Arena, Cardiff: Proceedings of the Nutrition Society: Cambridge University Press.
• Anstee QM, Goldin RD, Wright M, Martinelli A, Cox R, Thursz MR. Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies. Journal of Thrombosis and Haemostasis 2008, 6(8), 1336-1343.
• Martinelli A, Knapp S, Anstee QM, Worku M, Tommasi A, Zucoloto S, Goldin R, Thursz M. Effect of a thrombin receptor (protease-activated receptor 1, PAR-1) gene polymorphism in chronic hepatitis C liver fibrosis. Journal of Gastroenterology and Hepatology 2008, 23(9), 1403-1409.
• Northup PG, Sundaram V, Fallon MB, Reddy KR, Balogun RA, Sanyal AJ, Anstee QM, Hoffman MR, Ikura Y, Caldwell H, The Coagulation in Liver Disease Group. Hypercoagulation and thrombophilia in liver disease. Journal of Thrombosis and Haemostasis 2008, 6(1), 2-9.
• Knapp S, Hosie AM, Anstee QM, Thomos P, Mortensen M, Martinez A, Tymowska-Lalanne Z, McQuillin A, Gurling HM, Morgan MY, Kuo YT, Herlihy A, Bell JD, Robinson I, Fisher E, Brown S, Stephens D, Smart TG, Thomas HC. Identification of a model of alcohol preference and its similarity to human alcoholism. In: 59th Annual Meeting of the American Association for the Study of Liver Diseases. 2008, San Francisco, California: Hepatology: John Wiley & Sons, Inc.
• Cobbold JF, Anstee QM, Goldin RD, Cox RD, Thursz MR, Thomas HC, Taylor-Robinson SD, Cox IJ. Can disease progression in non-alcoholic fatty liver disease be predicted by metabolic biomarkers of lipid accumulation and peroxidation?. In: 42nd Annual Meeting of the European Association for the Study of the Liver. 2007, Barcelona, Spain: Journal of Hepatology: Elsevier BV.
• Cobbold JF, Chinthaplli S, Anstee QM, Goldin RD, Cox R, Thursz MR, Thomas HC, Taylor-Robinson SD, Cox IJ. Dietary constituents in mice are reflected in the hepatic lipid profile as detected by carbon-13 magic angle spinning magnetic resonance spectroscopy. In: 58th Annual Meeting of the American Association for the Study of Liver Diseases. 2007, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
• Anstee QM, Goldsworthy M, Goldin R, Thomas HC, Cox R, Thursz M. Microarray analysis demonstrates insulin resistance is central to NASH pathogenesis in the IGT/6 model and suggests a role for CEACAM-1 in disease pathogenesis. In: 42nd Annual Meeting of the European Association for the Study of the Liver. 2007, Barcelona, Spain: Journal of Hepatology: Elsevier BV.
• Anstee QM, Goldsworthy M, Goldin R, Thomas HC, Cox RD, Thursz M. Microarray principal components analysis demonstrates expression of Vanin-1 is a strong determinant of NASH pathogenesis in the IGT/6 model. In: 57th Annual Meeting of the American Association for the Study of Liver Diseases. 2006, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
• Anstee QM, Goldin RD. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. International Journal of Experimental Pathology 2006, 87(1), 1-16.
• Anstee QM, Wright M, Goldin R, Thomas HC, Thursz M. The factor V Leiden mutation accelerates disease progression in a mouse model of hepatic fibrosis induced by chronic carbon tetrachloride exposure. In: 55th Annual Meeting of the American Association for the Study of Liver Diseases. 2004, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
• Anstee QM, Goldsworthy M, Haynes A, Hugill A, Goldin R, Thursz M, Cox RD, Thomas H. A novel murine model of non-alcoholic steatohepatitis generated using a sensitised ENU mutagenesis screen. In: 54th Annual Meeting of the American Association for the Study of Liver Diseases. 2003, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
• Anstee QM, Forbes A. The safe use of percutaneous gastrostomy for enteral nutrition in patients with Crohn's disease. European Journal of Gastroenterology & Hepatology 2000, 12(10), 1089-1093.
• Lopes LM, Hughson E, Anstee QM, O'Neil D, Katz DR, Chain BM. Vectorial function of major histocompatibility complex class II in a human intestinal cell line. Immunology 1999, 98(1), 16-26.
• Anstee QM, Forbes A. [Abstract] Safety of percutaneous gastrostomy (PEG) feeding in Crohn's disease. Gastroenterology 1999, 116(4 (part 2)), A662 abstract no. G2889.
• Anstee QM, Forbes A. [Abstract] Safety of percutaneous gastrostomy (PEG) feeding in Crohn's disease. Gut 1999, 44(supplement 1), A36 abstract no. T144.