Professor Robert Taylor
Professor of Mitochondrial Pathology

  • Email: robert.taylor@ncl.ac.uk
  • Telephone: +44 (0) 191 208 3685
  • Fax: +44 (0) 191 282 4373
  • Address: Wellcome Trust Centre for Mitochondrial Research
    Institute of Neuroscience
    The Medical School
    Newcastle University
    Newcastle upon Tyne
    NE2 4HH

Roles and Responsibilities

Head of Laboratory, Newcastle Mitochondrial Diagnostic Service and Professor of Mitochondrial Pathology, Newcastle University
Co-ordinating Consultant Clinical Scientist, UK NHS Highly Specialised Rare Mitochondrial Disease Service of Adults and Children
Senior Tutor, Faculty MRes programmes and Faculty Graduate School Executive

Qualifications

BSc (Hons) Biochemistry (Newcastle University)
PhD (Newcastle University) 

DSc (Newcastle University)

FRCPath

Memberships

Fellow of the Royal College of Pathologists
British Society of Genetic Medicine
Society for the Study of Inborn Errors of Metabolism

World Muscle Society

British Inherited Metabolic Disease Group

American Society of Human Genetics

The Pathological Society of Great Britain and Ireland

Research Interests

The overall aim of my research is to use biochemical, molecular genetic and cell biological tools to diagnose and characterise the molecular pathology associated with human mitochondrial (both mtDNA-derived and Mendelian) disorders so as to understand disease mechanism and benefit patient care through the development of treatment and provision of accurate genetic advice.

 

This work is wide-ranging, encompassing projects aimed at:

1.        defining the prevalence, natural history and genotype:phenotype correlations associated mitochondrial disease

2.        improving the laboratory diagnosis and options for prenatal and preconceptional genetic screening

3.        documenting the neuropathological changes associated with mitochondrial genetic disease to delineate the molecular mechanisms leading to neuronal loss and neurological deficits in patients with mitochondrial disease

4.        using next generation sequencing strategies including whole exome and whole genome sequencing to identify novel disease genes associated with a range of mitochondrial oxidative phosphorylation defects (focusing primarly on mtDNA depletion syndromes, isolated complex I deficiency and generalised disorders of mitochondrial protein synthesis) with the broader aim of characterising the mechanisms which underlie post-transcriptional mitochondrial gene expression.

 

Uniquely positioned at the diagnostic-research interface, I work closely with all the Wellcome Trust Centre PIs and collaborate extensively with a number of International clinical and basic scientists.

 

Funding

The Wellcome Trust
MRC

The Lily Foundation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Department of Health

Undergraduate Teaching

BMS3013 Diseases of the Human Nervous System

Postgraduate Teaching

M.Res. Mitochondrial Biology and Medicine (MMB8034) - Joint module leader
M.Res. Neuroscience; Scientific basis of neurological disorders (MMB8020)