Prof. Steven Clifford
Professor of Molecular Paediatric Oncology
- Email: s.c.clifford@ncl.ac.uk
- Telephone: 0191 246 4422
- Fax: 0191 246 4301
- Address: Northern Institute for Cancer Research
Paul O'Gorman Building
Medical School
Framlington Place
Newcastle upon Tyne
NE2 4HH
Research Interests
The molecular basis of childhood brain tumour development
Molecular diagnostics for improved treatment individualisation in childhood brain tumour patients
Development and pre-clinical assessment of novel therapies for paediatric tumours
Selected Publications
- Lu Y; Ryan SL; Elliott DJ; Bignell GR; Futreal PA; Ellison DW; Bailey S; Clifford SC. Amplification and overexpression of Hsa-miR-3ob, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma. PLoS One 2009, 4(7), e6159.
- Clifford SC; O'Toole KT; Ellison DW. Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: requirements for the validation of potential prognostic biomarkers. Cell Cycle 2009, 8(5), 787-787.
- Hayden JT; Fruhwald MC; Hasselblatt M; Ellison DW; Bailey S; Clifford SC. Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children. Cell Cycle 2009, 8(11), 1806-1807.
- McCabe MG; Ichimura K; Pearson DM; Liu L; Clifford SC; Ellison DW; Collins VP. Novel mechanisms of gene disruption at the medulloblastoma isodicentric 17p11 breakpoint. Genes, Chromosomes & Cancer 2009, 48(2), 121-131.
- Pizer B; Clifford SC. Medulloblastoma: new insights into biology and treatment. Archives of Disease in Childhood - Education and Practice 2008, 93(5), 137-44.
- Langdon JA; Lamont JM; Scott DK; Dyer S; Prebble E; Bown N; Grundy RG; Ellison DW; Clifford SC. Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma. Genes, Chromosomes & Cancer 2006, 45(1), 47-60.
Research Roles
Leader, Paediatric Brain Tumour Research Group, NICR, Newcastle University.
Chair, Newcastle University Childhood Cancer Research Group.
Member, UK Children's Cancer & Leukaemia Group (CCLG) CNS Tumours Division (and PNET sub-group).
Member, CCLG Biological Studies Steering Group.
Member, CCLG Therapeutics Steering Group.
Member, International Society for Paediatric Oncology (SIOP-Europe) Brain Tumour Group & PNET study group.
Co-Chair, SIOP-Europe PNET Biology Group.
Member, Innovative Therapies for Children with Cancer (ITCC): pan-European co-ordinating group for new drug development and clinical trials in paediatric oncology.
Member, Scientific & Medical Advisory Board, Samantha Dickson Brain Tumour Trust.
Member, Grants Review & Monitoring Committee, Samantha Dickson Brain Tumour Trust.
Member, Scientific Advisory Board, The Neuroblastoma Society.
Postgraduate Supervision
PhD students
Clinical Fellows
MRes project students
National Institute for Health Research (NIHR) Integrated Academic Training Programme (Academic Foundation Programme students, Academic Clinical Lecturers)
Funding
Ali's Dream
Cancer & Leukaemia in Children (CLIC)
Cancer Research UK (CR-UK)
Charlie's Challenge
Commission of the European Union
JGW Patterson Foundation (JGWP)
Katie Trust
Newcastle Healthcare Charity
North of England Children's Cancer Research (NECCR)
Samantha Dickson Brain Tumour Trust (SDBTT)
Sport Aiding Medical Research for Kids (SPARKS)
Memberships
UK Children’s Cancer & Leukaemia Group (CCLG).
British Neuro-oncology Society (BNOS).
British Association for Cancer Research (BACR).
American Association for Cancer Research (AACR).
Undergraduate Teaching
Module leader, BMS3012 “Cancer Biology and Therapy”, 3rd year undergraduate module, BSc in Biomedical Sciences.
Lectures, BGM3024 "The Molecular Basis of Cancer", 3rd yr undergraduate module, BSc programmes.
Postgraduate Teaching
Post Graduate Co-ordinator, Northern Institute for Cancer Research, Newcastle University.
On-line teaching module for MSc in Oncology and Paliative Care.
