Newcastle University

The incidence and severity of hypoxia associated with 99Tcm Technegas ventilation scintigraphy and 99Tcm MAA perfusion scintigraphy (1992)

Author(s): J. M. James;J. J. Lloyd;B. C. Leahy;R. A. Shields;M. C. Prescott;H. J. Testa

• : The incidence and severity of hypoxia associated with 99Tcm Technegas ventilation scintigraphy and 99Tcm MAA perfusion scintigraphy

Abstract: Inhalation of the ventilatory radiopharmaceutical 99Tcm Technegas leads, in some patients, to symptoms that may be attributed to temporary lowering of oxygen saturation. In order to evaluate this, oxygen saturation was measured by pulse oximetry in a series of patients undergoing Technegas ventilation scintigraphy. A decrease in oxygen saturation was recorded in 87% of the patient group. The mean change, as a percentage of the initial value, was 8.3% (range 1-24%). Hypoxia arising in association with Technegas administration may be reduced by pre-oxygenation. In patients who were pre-oxygenated, oxygen saturation did not fall below 85% (PaO2: 50 mmHg) but in 39% of those not pre-oxygenated the value fell below this level. Oxygen saturation was also monitored in a series of patients undergoing perfusion scintigraphy. In 17% of patients a decrease was recorded (range 2-11%). In view of the large number of perfusion scans performed annually in this department and elsewhere without untoward effect, such temporary decreases in oxygen saturation presumably present no hazard to the patient.

• Short Title: The incidence and severity of hypoxia associated with 99Tcm Technegas ventilation scintigraphy and 99Tcm MAA perfusion scintigraphy

• Journal: British Journal of Radiology
• Volume: 65
• Issue: 773
• Pages: 403-8
• Publication type: Article
• Bibliographic status: Published

Keywords: Adolescence Adult Aged Aged, 80 and over Albumins/ae [Adverse Effects] *Anoxia/et [Etiology] Comparative Study Female Graphite/ae [Adverse Effects] Human *Lung/ri [Radionuclide Imaging] Male Middle Age Oxygen/ad [Administration & Dosage] Oxygen/bl [Blood] *Sodium Pertechnetate Tc 99m/ae [Adverse Effects] Support, Non-U.S. Gov't *Technetium Tc 99m Aggregated Albumin/ae [Adverse Effects]