Seminar 25 November 2009: Professor David Holden, FRS
Location: Dental Lecture Theatre F
Time/Date: 25th November 2009, 16:00 - 17:00
The Institute for Cell and Molecular Biosciences will be holding the following seminar:
TITLE: A Fresh Look at the Intracellular Biology of Salmonella
SPEAKER: Professor David Holden, FRS
DATE AND TIME: 25 November 2009 at 4pm
VENUE: Dental Lecture Theatre F
Professor Holden invented signature-tagged mutagenesis, which has been used by many groups worldwide in indentifying genes involved in virulence, among other things. He has also made many contributions to understanding the host pathogen interaction.
Publications include:
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence.Rytkönen A, Poh J, Garmendia J, Boyle C, Thompson A, Liu M, Freemont P, Hinton JC, Holden DW. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3502-7.
SteC is a Salmonella kinase required for SPI-2-dependent F-actin remodelling. Poh J, Odendall C, Spanos A, Boyle C, Liu M, Freemont P, Holden DW. Cell Microbiol. 2008 Jan;10(1):20-30.
Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Mazurkiewicz P, Tang CM, Boone C, Holden DW. Nat Rev Genet. 2006 Dec;7(12):929-39.
Published: 6th August 2009
