published on: 4th March 2015
PI(3)P, the product of VPS34, regulates canonical autophagy; however, mammalian cells can produce autophagosomes through enigmatic noncanonical VPS34-independent pathways. Vicinanza et al. show that PI(5) P can regulate autophagy, even in cells where VPS34 is compromised and acts via PI(3)P effectors. This provides a mechanistic explanation for forms of noncanonical autophagy.
published on: 2nd March 2015
published on: 27th February 2015
published on: 24th February 2015
Membrane Recognition and Dynamics of the RNA Degradosome
published on: 4th February 2015