"Analytical ultracentrifugation is perhaps the most striking contribution of physical chemistry to the study of biological macromolecules"
J D Watson "The Molecular Biology of the Gene"
Analytical ultracentrifugation is the direct method which gives information about the mass, structure and interactions of purified proteins in dilute solutions. The method is addressed to study the hydrodynamic behaviour of biomolecules subjected to a centrifugal field. The systems subjected to analytical ultracentrifugation study could be as follows:
Modern analytical ultracentrifugation is not simply a technique - it is part of global description of biomolecular systems in-vitro
What we will do: