Our work on ageing involves looking at how our gut bacteria alter with age and what consequences this may have for healthy ageing, and how sunlight, inflammation and oxygen cause stress in ageing cells and affect telomeres, structures in chromosomes that protect against ageing.
We have a deep interest in essential trace metals and are studying how ageing cells handle copper, one of these metals.
The staff listed are involved in age-related research in the following areas:
- Prof Thomas Kirkwood CBE – evolution and genetics of ageing
- Dr Viktor Korolchuk – intracellular protein trafficking and degradation pathways
- Prof Dave Lydall – human genetic defects in DNA-damage responses which lead to diseases associated with ageing and cancer. DNA damage/repair and telomere maintenance in ageing cells
- Dr Laura Maringele – cellular responses to damaged telomeres, telomeres being DNA and protein complexes that protect the ends chromosomes in eukaryotic cells
- Dr Joao Passos – role of signalling pathways connecting telomeres to reactive oxygen species (ROS) and mitochondrial dysfunction in cellular ageing
- Dr Alberto Sanz Montero
- Dr Gabriele Saretzki – role of oxidative stress and mitochondria in the ageing process and cellular senescence
- Dr Daryl Shanley – developing mathematical models that examine ageing as an integral part of an optimal life history
- Dr Liz Veal and Prof Brian Morgan – exposure to sunlight, immune cell attack and aerobic metabolism generate highly toxic chemicals and the impact of this causing stress in ageing cells
- Prof Harry Gilbert and Dr Dave Bolam – comparative analysis of the microbiome in individuals as they age
- Dr Julian Rutherford – copper proteome in ageing cells
- Prof Thomas von Zglinicki – cellular ageing and telomere maintenance