Institute for Cell and Molecular Biosciences

Biogerontology

Biogerontology

Our work aims to develop further understanding of the essential networks of stress responses and signalling processes that govern ageing at the molecular and cellular scale, aided by a combination of experimentation and mathematical modelling.

Our work includes Systems Biology and Biomarkers.

We are looking for interventions aimed at slowing down the ageing process and at identifying better candidates for markers of biological age. These will be evaluated and tested for their predictive power in population-based, pre-clinical and clinical human studies.

Our staff are involved in the Newcastle 85+ Study, a major study of health and ageing in the oldest old population (those aged 85 years and older). Since 2006 this study has recruited a birth cohort of more than one thousand 85 year olds from Newcastle and North Tyneside.

Research in this area is conducted in close collaboration with the:

Research group leads and specialisms

  • Kirkwood: the ageing cell
  • Korolchuk: cell division (eukaryote); cell sensing and signalling (eukaryote); cancer cell biology; the ageing cell
  • Lydall:
  • Maringele: cell division (eukaryote); cell sensing and signalling (eukaryote); cancer cell biology; the ageing cell
  • Passos: biology of ageing; the ageing cell; cell sensing and signalling 
  • Sanz Montero: biology of ageing; the ageing cell; cell sensing and signalling (eukaryote)
  • Saretzki: the ageing cell; cell sensing and signalling (eukaryote)
  • Shanley: cell sensing and signalling (eukaryote); the ageing cell 
  • Veal:
  • von Zglinicki: cell sensing and signalling (eukaryote); the ageing cell; cancer cell biology