Institute for Cell and Molecular Biosciences

Epithelial Biology

Epithelial Biology

Our research in epithelial biology focuses on the processes governing the specialised roles of epithelial cells in health and disease.

Specific areas of interest are:

  • transport across epithelia
  • interaction of diet and nutrition on cellular processes
  • microbial-interactions
  • mucosal protection
  • epithelial defence

Insights into abnormalities in physiological processes are of value in the understanding and the correction of a large number of human diseases.

Research group leads and specialisms

  • Colin Brown: epithelial transport; drug transporters; organic anion transporters; cloned transporters; drug-drug interactions; drug screening
  • Ford: molecular nutrition; zinc homeostasis; epigenetic effects on diet; surtuins; DNA methylation
  • Gray: epithelial ion transport in health and disease; cystic fibrosis; pancreatitis; COPD
  • Hall: epithelial defences; antimicrobial peptides; innate immunity bladder; gut
  • Hesketh: effects on nutrients on gene expression; selenium and selenoproteins; RNA localisation
  • Hirst: epithelial transporters; oral drug bioavailability; ABC transporters; enterocyte homeostasis
  • Pearson: gastro-oesophageal reflex; fundoplication; biomarkers; alginate; bile acids
  • Thwaites: intestinal epithelial transport; nutrient and drug transporters; neuro-hormonal mechanisms and components of diet; intracellular pH regulation; membrane transport in neuro-blastoma cells
  • Werner: gene regulation by natural antisense transcript; epithelial Na/phosphate transport

Find out about the Epithelial Research Group.