Regulation of the ReIA (p65) transactivation domain (2008)

Author(s): O'Shea JM, Perkins ND

    Abstract: The RelA (p65) NF-κB (nuclear factor κB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function.

      • Date: 01-08-2008
      • Journal: Biochemical Society Transactions
      • Volume: 36
      • Issue: 4
      • Pages: 603-608
      • Publisher: Portland Press Ltd.
      • Publication type: Article
      • Bibliographic status: Published

      Professor Neil Perkins
      Prof of Gene Exp & Signalling